| Full name: sperm associated antigen 5 | Alias Symbol: DEEPEST|MAP126|hMAP126 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 10615 | HGNC ID: HGNC:13452 | Ensembl Gene: ENSG00000076382 | OMIM ID: 615562 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPAG5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPAG5 | 10615 | 203145_at | 1.4063 | 0.0070 | |
| GSE20347 | SPAG5 | 10615 | 203145_at | 1.3271 | 0.0000 | |
| GSE23400 | SPAG5 | 10615 | 203145_at | 0.2779 | 0.0000 | |
| GSE26886 | SPAG5 | 10615 | 203145_at | 1.5199 | 0.0000 | |
| GSE29001 | SPAG5 | 10615 | 203145_at | 1.4467 | 0.0007 | |
| GSE38129 | SPAG5 | 10615 | 203145_at | 1.6744 | 0.0000 | |
| GSE45670 | SPAG5 | 10615 | 203145_at | 1.4074 | 0.0001 | |
| GSE53622 | SPAG5 | 10615 | 52230 | 1.9972 | 0.0000 | |
| GSE53624 | SPAG5 | 10615 | 52230 | 2.0442 | 0.0000 | |
| GSE63941 | SPAG5 | 10615 | 203145_at | 2.3618 | 0.0005 | |
| GSE77861 | SPAG5 | 10615 | 203145_at | 1.1757 | 0.0033 | |
| GSE97050 | SPAG5 | 10615 | A_23_P89509 | 1.4070 | 0.1034 | |
| SRP007169 | SPAG5 | 10615 | RNAseq | 2.4149 | 0.0000 | |
| SRP008496 | SPAG5 | 10615 | RNAseq | 1.8897 | 0.0000 | |
| SRP064894 | SPAG5 | 10615 | RNAseq | 1.9424 | 0.0000 | |
| SRP133303 | SPAG5 | 10615 | RNAseq | 1.6687 | 0.0000 | |
| SRP159526 | SPAG5 | 10615 | RNAseq | 1.7466 | 0.0000 | |
| SRP193095 | SPAG5 | 10615 | RNAseq | 1.2126 | 0.0000 | |
| SRP219564 | SPAG5 | 10615 | RNAseq | 1.3264 | 0.0206 | |
| TCGA | SPAG5 | 10615 | RNAseq | 0.9908 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by SPAG5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPAG5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPAG5 | 10615 | 9 | 1 | 20 | |
| GSE20123 | SPAG5 | 10615 | 9 | 1 | 20 | |
| GSE43470 | SPAG5 | 10615 | 0 | 1 | 42 | |
| GSE46452 | SPAG5 | 10615 | 33 | 1 | 25 | |
| GSE47630 | SPAG5 | 10615 | 7 | 1 | 32 | |
| GSE54993 | SPAG5 | 10615 | 2 | 3 | 65 | |
| GSE54994 | SPAG5 | 10615 | 7 | 6 | 40 | |
| GSE60625 | SPAG5 | 10615 | 4 | 0 | 7 | |
| GSE74703 | SPAG5 | 10615 | 0 | 1 | 35 | |
| GSE74704 | SPAG5 | 10615 | 7 | 1 | 12 | |
| TCGA | SPAG5 | 10615 | 21 | 10 | 65 |
Total number of gains: 99; Total number of losses: 26; Total Number of normals: 363.
Somatic mutations of SPAG5:
Generating mutation plots.
Highly correlated genes for SPAG5:
Showing top 20/2104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPAG5 | UBE2T | 0.863834 | 9 | 0 | 9 |
| SPAG5 | BUB1 | 0.857829 | 11 | 0 | 11 |
| SPAG5 | CCNB2 | 0.847716 | 12 | 0 | 12 |
| SPAG5 | KIF4A | 0.840889 | 12 | 0 | 12 |
| SPAG5 | TPX2 | 0.836989 | 13 | 0 | 13 |
| SPAG5 | NUF2 | 0.835316 | 9 | 0 | 8 |
| SPAG5 | NCAPH | 0.832774 | 9 | 0 | 9 |
| SPAG5 | TTK | 0.827961 | 12 | 0 | 12 |
| SPAG5 | TIMELESS | 0.827815 | 13 | 0 | 13 |
| SPAG5 | KIF14 | 0.827281 | 13 | 0 | 13 |
| SPAG5 | CDCA3 | 0.82726 | 13 | 0 | 13 |
| SPAG5 | TOP2A | 0.824025 | 13 | 0 | 13 |
| SPAG5 | CENPF | 0.823011 | 13 | 0 | 12 |
| SPAG5 | AURKB | 0.822526 | 13 | 0 | 13 |
| SPAG5 | NEK2 | 0.815998 | 13 | 0 | 12 |
| SPAG5 | BIRC5 | 0.814486 | 12 | 0 | 12 |
| SPAG5 | RAD51AP1 | 0.81447 | 13 | 0 | 13 |
| SPAG5 | CDC45 | 0.814099 | 12 | 0 | 12 |
| SPAG5 | MTFR2 | 0.81152 | 7 | 0 | 7 |
| SPAG5 | KNSTRN | 0.810302 | 7 | 0 | 7 |
For details and further investigation, click here
