| Full name: neuronal guanine nucleotide exchange factor | Alias Symbol: ARHGEF27 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 25791 | HGNC ID: HGNC:7807 | Ensembl Gene: ENSG00000066248 | OMIM ID: 605991 |
| Drug and gene relationship at DGIdb | |||
NGEF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of NGEF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NGEF | 25791 | 227240_at | -0.9520 | 0.6061 | |
| GSE26886 | NGEF | 25791 | 227240_at | 0.0117 | 0.9794 | |
| GSE45670 | NGEF | 25791 | 227240_at | -0.1286 | 0.7660 | |
| GSE53622 | NGEF | 25791 | 23032 | -0.2826 | 0.0000 | |
| GSE53624 | NGEF | 25791 | 23032 | 0.0733 | 0.1253 | |
| GSE63941 | NGEF | 25791 | 227240_at | 1.7150 | 0.0227 | |
| GSE77861 | NGEF | 25791 | 227240_at | 0.4213 | 0.2702 | |
| GSE97050 | NGEF | 25791 | A_23_P102364 | 0.1043 | 0.6635 | |
| SRP007169 | NGEF | 25791 | RNAseq | -0.5923 | 0.3385 | |
| SRP008496 | NGEF | 25791 | RNAseq | -0.2889 | 0.5502 | |
| SRP064894 | NGEF | 25791 | RNAseq | -0.9577 | 0.0029 | |
| SRP133303 | NGEF | 25791 | RNAseq | -0.4264 | 0.3697 | |
| SRP159526 | NGEF | 25791 | RNAseq | -0.2828 | 0.4379 | |
| SRP193095 | NGEF | 25791 | RNAseq | 0.0130 | 0.9655 | |
| SRP219564 | NGEF | 25791 | RNAseq | -1.2099 | 0.1790 | |
| TCGA | NGEF | 25791 | RNAseq | 0.0395 | 0.8504 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NGEF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NGEF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NGEF | 25791 | 1 | 12 | 17 | |
| GSE20123 | NGEF | 25791 | 1 | 12 | 17 | |
| GSE43470 | NGEF | 25791 | 1 | 9 | 33 | |
| GSE46452 | NGEF | 25791 | 0 | 5 | 54 | |
| GSE47630 | NGEF | 25791 | 4 | 5 | 31 | |
| GSE54993 | NGEF | 25791 | 3 | 2 | 65 | |
| GSE54994 | NGEF | 25791 | 6 | 10 | 37 | |
| GSE60625 | NGEF | 25791 | 0 | 3 | 8 | |
| GSE74703 | NGEF | 25791 | 1 | 7 | 28 | |
| GSE74704 | NGEF | 25791 | 1 | 5 | 14 | |
| TCGA | NGEF | 25791 | 11 | 30 | 55 |
Total number of gains: 29; Total number of losses: 100; Total Number of normals: 359.
Somatic mutations of NGEF:
Generating mutation plots.
Highly correlated genes for NGEF:
Showing top 20/35 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NGEF | ZC3HAV1L | 0.731337 | 3 | 0 | 3 |
| NGEF | KCNG1 | 0.685798 | 3 | 0 | 3 |
| NGEF | DMKN | 0.650682 | 3 | 0 | 3 |
| NGEF | CELSR1 | 0.633232 | 4 | 0 | 3 |
| NGEF | MVD | 0.624181 | 3 | 0 | 3 |
| NGEF | TMEM79 | 0.613987 | 4 | 0 | 3 |
| NGEF | LMNA | 0.613898 | 3 | 0 | 3 |
| NGEF | CALB2 | 0.608006 | 4 | 0 | 3 |
| NGEF | AHNAK2 | 0.604031 | 5 | 0 | 3 |
| NGEF | KCNK1 | 0.597549 | 4 | 0 | 3 |
| NGEF | ATG16L1 | 0.587893 | 4 | 0 | 3 |
| NGEF | C3orf67 | 0.582409 | 4 | 0 | 3 |
| NGEF | MARK3 | 0.579934 | 4 | 0 | 3 |
| NGEF | DAGLB | 0.576967 | 3 | 0 | 3 |
| NGEF | FKBP8 | 0.574355 | 3 | 0 | 3 |
| NGEF | CITED4 | 0.570292 | 5 | 0 | 3 |
| NGEF | PPP1CA | 0.568582 | 3 | 0 | 3 |
| NGEF | LFNG | 0.56727 | 4 | 0 | 3 |
| NGEF | PLA2G4F | 0.566373 | 5 | 0 | 3 |
| NGEF | SFN | 0.555379 | 4 | 0 | 3 |
For details and further investigation, click here
