LMNA

 

Full name: lamin A/C Alias Symbol: HGPS|MADA
Type: protein-coding gene Cytoband: 1q22
Entrez ID: 4000 HGNC ID: HGNC:6636 Ensembl Gene: ENSG00000160789 OMIM ID: 150330
Drug and gene relationship at DGIdb
Screen Evidence:

 

LMNA involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of LMNA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LMNA 4000 203411_s_at -0.0286 0.9631
GSE20347 LMNA 4000 212086_x_at -0.1979 0.1104
GSE23400 LMNA 4000 212086_x_at -0.2293 0.0037
GSE26886 LMNA 4000 203411_s_at 0.2731 0.1636
GSE29001 LMNA 4000 212086_x_at -0.3941 0.1928
GSE38129 LMNA 4000 212086_x_at -0.2044 0.1347
GSE45670 LMNA 4000 212086_x_at 0.0410 0.8183
GSE53622 LMNA 4000 39599 -1.0124 0.0000
GSE53624 LMNA 4000 39599 -1.0335 0.0000
GSE63941 LMNA 4000 203411_s_at -0.6382 0.2297
GSE77861 LMNA 4000 212086_x_at 0.8058 0.0232
GSE97050 LMNA 4000 A_33_P3408762 -0.4833 0.2310
SRP007169 LMNA 4000 RNAseq -0.5489 0.0774
SRP008496 LMNA 4000 RNAseq -0.4163 0.0942
SRP064894 LMNA 4000 RNAseq 0.0675 0.8253
SRP133303 LMNA 4000 RNAseq -0.1372 0.5387
SRP159526 LMNA 4000 RNAseq 0.2696 0.3150
SRP193095 LMNA 4000 RNAseq 0.4240 0.0048
SRP219564 LMNA 4000 RNAseq 0.2229 0.5810
TCGA LMNA 4000 RNAseq 0.0035 0.9365

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by LMNA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LMNA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LMNA 4000 14 0 16
GSE20123 LMNA 4000 13 0 17
GSE43470 LMNA 4000 7 2 34
GSE46452 LMNA 4000 2 1 56
GSE47630 LMNA 4000 14 0 26
GSE54993 LMNA 4000 0 5 65
GSE54994 LMNA 4000 16 0 37
GSE60625 LMNA 4000 0 0 11
GSE74703 LMNA 4000 7 2 27
GSE74704 LMNA 4000 6 0 14
TCGA LMNA 4000 38 2 56

Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.  

 

Somatic mutations of LMNA:

 

Generating mutation plots.

 

Highly correlated genes for LMNA:

 

Showing top 20/269 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LMNACCDC510.767481303
LMNARASAL20.750951303
LMNATTC80.747516303
LMNACBL0.741886404
LMNANEK90.74005303
LMNAPPP1R210.739378303
LMNASPIRE10.735117303
LMNAZFYVE210.732474303
LMNAFHL50.729768303
LMNADBNL0.725823303
LMNASRGAP20.707103303
LMNAEFNB20.705044404
LMNACYP21A20.702145303
LMNACLEC3B0.701835303
LMNALRRC400.698941303
LMNASLCO4A10.686782303
LMNAANGPTL10.685193303
LMNARGS7BP0.684767303
LMNACASC30.683001303
LMNAPRDM50.682963403

For details and further investigation, click here