| Full name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Alias Symbol: SCDO3 | ||
| Type: protein-coding gene | Cytoband: 7p22.3 | ||
| Entrez ID: 3955 | HGNC ID: HGNC:6560 | Ensembl Gene: ENSG00000106003 | OMIM ID: 602576 |
| Drug and gene relationship at DGIdb | |||
LFNG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of LFNG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LFNG | 3955 | 228762_at | 0.3104 | 0.6462 | |
| GSE20347 | LFNG | 3955 | 215270_at | -0.1152 | 0.0881 | |
| GSE23400 | LFNG | 3955 | 215270_at | -0.1925 | 0.0000 | |
| GSE26886 | LFNG | 3955 | 228762_at | 0.1639 | 0.5467 | |
| GSE29001 | LFNG | 3955 | 215270_at | -0.1729 | 0.1403 | |
| GSE38129 | LFNG | 3955 | 215270_at | -0.1854 | 0.0276 | |
| GSE45670 | LFNG | 3955 | 228762_at | 0.2462 | 0.4829 | |
| GSE53622 | LFNG | 3955 | 83698 | 0.2217 | 0.0834 | |
| GSE53624 | LFNG | 3955 | 83698 | 0.3483 | 0.0006 | |
| GSE63941 | LFNG | 3955 | 228762_at | 1.6324 | 0.0440 | |
| GSE77861 | LFNG | 3955 | 228762_at | 0.3513 | 0.1478 | |
| GSE97050 | LFNG | 3955 | A_23_P8452 | 0.2512 | 0.3713 | |
| SRP007169 | LFNG | 3955 | RNAseq | 0.3594 | 0.4434 | |
| SRP008496 | LFNG | 3955 | RNAseq | 1.2438 | 0.0170 | |
| SRP064894 | LFNG | 3955 | RNAseq | -0.2050 | 0.5274 | |
| SRP133303 | LFNG | 3955 | RNAseq | 0.0552 | 0.8269 | |
| SRP159526 | LFNG | 3955 | RNAseq | 0.6928 | 0.1361 | |
| SRP193095 | LFNG | 3955 | RNAseq | -0.1469 | 0.5927 | |
| SRP219564 | LFNG | 3955 | RNAseq | 0.0180 | 0.9686 | |
| TCGA | LFNG | 3955 | RNAseq | -0.3577 | 0.0106 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LFNG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LFNG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LFNG | 3955 | 14 | 0 | 16 | |
| GSE20123 | LFNG | 3955 | 14 | 0 | 16 | |
| GSE43470 | LFNG | 3955 | 7 | 2 | 34 | |
| GSE46452 | LFNG | 3955 | 13 | 1 | 45 | |
| GSE47630 | LFNG | 3955 | 10 | 1 | 29 | |
| GSE54993 | LFNG | 3955 | 0 | 7 | 63 | |
| GSE54994 | LFNG | 3955 | 21 | 2 | 30 | |
| GSE60625 | LFNG | 3955 | 0 | 0 | 11 | |
| GSE74703 | LFNG | 3955 | 7 | 1 | 28 | |
| GSE74704 | LFNG | 3955 | 9 | 0 | 11 | |
| TCGA | LFNG | 3955 | 56 | 5 | 35 |
Total number of gains: 151; Total number of losses: 19; Total Number of normals: 318.
Somatic mutations of LFNG:
Generating mutation plots.
Highly correlated genes for LFNG:
Showing top 20/95 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LFNG | GPR180 | 0.724792 | 3 | 0 | 3 |
| LFNG | NPW | 0.722937 | 3 | 0 | 3 |
| LFNG | MTFP1 | 0.694255 | 4 | 0 | 4 |
| LFNG | C2orf81 | 0.693999 | 3 | 0 | 3 |
| LFNG | IL24 | 0.687823 | 4 | 0 | 4 |
| LFNG | DNER | 0.678911 | 3 | 0 | 3 |
| LFNG | PRKAR1B | 0.678843 | 3 | 0 | 3 |
| LFNG | PLCH2 | 0.651493 | 4 | 0 | 4 |
| LFNG | SMARCB1 | 0.645808 | 4 | 0 | 3 |
| LFNG | EML6 | 0.635981 | 4 | 0 | 3 |
| LFNG | BAIAP2 | 0.633843 | 5 | 0 | 5 |
| LFNG | HOXC9 | 0.630543 | 3 | 0 | 3 |
| LFNG | IGSF3 | 0.628362 | 4 | 0 | 4 |
| LFNG | WDR78 | 0.624442 | 3 | 0 | 3 |
| LFNG | OPN3 | 0.617587 | 4 | 0 | 3 |
| LFNG | GBX2 | 0.611614 | 4 | 0 | 3 |
| LFNG | IGFL2 | 0.60566 | 4 | 0 | 3 |
| LFNG | RARG | 0.603676 | 5 | 0 | 4 |
| LFNG | PINX1 | 0.602599 | 3 | 0 | 3 |
| LFNG | MARVELD3 | 0.601374 | 4 | 0 | 3 |
For details and further investigation, click here
