| Full name: anterior gradient 2, protein disulphide isomerase family member | Alias Symbol: XAG-2|HAG-2|AG2|PDIA17 | ||
| Type: protein-coding gene | Cytoband: 7p21.1 | ||
| Entrez ID: 10551 | HGNC ID: HGNC:328 | Ensembl Gene: ENSG00000106541 | OMIM ID: 606358 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AGR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGR2 | 10551 | 209173_at | -0.6048 | 0.7682 | |
| GSE20347 | AGR2 | 10551 | 209173_at | 0.6404 | 0.2073 | |
| GSE23400 | AGR2 | 10551 | 209173_at | -0.3460 | 0.2251 | |
| GSE26886 | AGR2 | 10551 | 209173_at | 1.7296 | 0.0020 | |
| GSE29001 | AGR2 | 10551 | 209173_at | 0.2782 | 0.5959 | |
| GSE38129 | AGR2 | 10551 | 209173_at | 0.2938 | 0.6115 | |
| GSE45670 | AGR2 | 10551 | 209173_at | 0.4324 | 0.7008 | |
| GSE53622 | AGR2 | 10551 | 26881 | -0.7218 | 0.1386 | |
| GSE53624 | AGR2 | 10551 | 26881 | -1.0384 | 0.0014 | |
| GSE63941 | AGR2 | 10551 | 209173_at | 5.2919 | 0.0255 | |
| GSE77861 | AGR2 | 10551 | 209173_at | 0.5610 | 0.6004 | |
| GSE97050 | AGR2 | 10551 | A_23_P31407 | 0.5561 | 0.4650 | |
| SRP007169 | AGR2 | 10551 | RNAseq | 2.3211 | 0.0049 | |
| SRP008496 | AGR2 | 10551 | RNAseq | 1.5931 | 0.0059 | |
| SRP064894 | AGR2 | 10551 | RNAseq | -2.6221 | 0.0010 | |
| SRP133303 | AGR2 | 10551 | RNAseq | -0.0119 | 0.9904 | |
| SRP159526 | AGR2 | 10551 | RNAseq | 0.4914 | 0.6023 | |
| SRP193095 | AGR2 | 10551 | RNAseq | -1.0701 | 0.1920 | |
| SRP219564 | AGR2 | 10551 | RNAseq | 3.4738 | 0.0033 | |
| TCGA | AGR2 | 10551 | RNAseq | -1.1769 | 0.0002 |
Upregulated datasets: 5; Downregulated datasets: 3.
Survival by AGR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGR2 | 10551 | 15 | 2 | 13 | |
| GSE20123 | AGR2 | 10551 | 15 | 2 | 13 | |
| GSE43470 | AGR2 | 10551 | 5 | 0 | 38 | |
| GSE46452 | AGR2 | 10551 | 11 | 1 | 47 | |
| GSE47630 | AGR2 | 10551 | 9 | 1 | 30 | |
| GSE54993 | AGR2 | 10551 | 0 | 6 | 64 | |
| GSE54994 | AGR2 | 10551 | 21 | 1 | 31 | |
| GSE60625 | AGR2 | 10551 | 0 | 0 | 11 | |
| GSE74703 | AGR2 | 10551 | 5 | 0 | 31 | |
| GSE74704 | AGR2 | 10551 | 9 | 2 | 9 | |
| TCGA | AGR2 | 10551 | 56 | 5 | 35 |
Total number of gains: 146; Total number of losses: 20; Total Number of normals: 322.
Somatic mutations of AGR2:
Generating mutation plots.
Highly correlated genes for AGR2:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGR2 | NKX3-1 | 0.635894 | 6 | 0 | 6 |
| AGR2 | SLC44A4 | 0.631328 | 8 | 0 | 6 |
| AGR2 | PKIB | 0.630495 | 4 | 0 | 3 |
| AGR2 | POP5 | 0.628239 | 3 | 0 | 3 |
| AGR2 | KIF22 | 0.626895 | 3 | 0 | 3 |
| AGR2 | LRRC26 | 0.624658 | 3 | 0 | 3 |
| AGR2 | CCDC57 | 0.616079 | 3 | 0 | 3 |
| AGR2 | RDH10 | 0.61593 | 3 | 0 | 3 |
| AGR2 | PRR15 | 0.614676 | 4 | 0 | 3 |
| AGR2 | OVOL2 | 0.614247 | 5 | 0 | 3 |
| AGR2 | AZGP1 | 0.610549 | 6 | 0 | 5 |
| AGR2 | KRT18 | 0.609574 | 6 | 0 | 6 |
| AGR2 | ZG16B | 0.608756 | 7 | 0 | 5 |
| AGR2 | CAPN8 | 0.608595 | 5 | 0 | 4 |
| AGR2 | WFDC2 | 0.606521 | 8 | 0 | 7 |
| AGR2 | KIF2C | 0.604604 | 3 | 0 | 3 |
| AGR2 | AGR3 | 0.603023 | 7 | 0 | 5 |
| AGR2 | BPIFB2 | 0.59932 | 5 | 0 | 3 |
| AGR2 | CENPV | 0.597329 | 3 | 0 | 3 |
| AGR2 | TSPAN1 | 0.596899 | 13 | 0 | 11 |
For details and further investigation, click here
