| Full name: plakophilin 1 | Alias Symbol: B6P | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 5317 | HGNC ID: HGNC:9023 | Ensembl Gene: ENSG00000081277 | OMIM ID: 601975 |
| Drug and gene relationship at DGIdb | |||
Expression of PKP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKP1 | 5317 | 221854_at | 0.6428 | 0.3734 | |
| GSE20347 | PKP1 | 5317 | 221854_at | -0.3132 | 0.1301 | |
| GSE23400 | PKP1 | 5317 | 221854_at | 0.1416 | 0.4801 | |
| GSE26886 | PKP1 | 5317 | 221854_at | -0.4601 | 0.1993 | |
| GSE29001 | PKP1 | 5317 | 221854_at | -0.0034 | 0.9923 | |
| GSE38129 | PKP1 | 5317 | 221854_at | 0.8231 | 0.1739 | |
| GSE45670 | PKP1 | 5317 | 221854_at | 0.3332 | 0.0439 | |
| GSE53622 | PKP1 | 5317 | 144204 | 0.0832 | 0.8184 | |
| GSE53624 | PKP1 | 5317 | 144204 | -0.4507 | 0.0009 | |
| GSE63941 | PKP1 | 5317 | 221854_at | 3.9454 | 0.0068 | |
| GSE77861 | PKP1 | 5317 | 221854_at | 0.5293 | 0.0879 | |
| GSE97050 | PKP1 | 5317 | A_33_P3393971 | 1.7215 | 0.3214 | |
| SRP007169 | PKP1 | 5317 | RNAseq | -0.9212 | 0.0006 | |
| SRP008496 | PKP1 | 5317 | RNAseq | -1.0807 | 0.0012 | |
| SRP064894 | PKP1 | 5317 | RNAseq | -0.7248 | 0.0864 | |
| SRP133303 | PKP1 | 5317 | RNAseq | -0.2813 | 0.3692 | |
| SRP159526 | PKP1 | 5317 | RNAseq | 0.1106 | 0.8812 | |
| SRP219564 | PKP1 | 5317 | RNAseq | -0.4533 | 0.6782 | |
| TCGA | PKP1 | 5317 | RNAseq | 1.2459 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by PKP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKP1 | 5317 | 12 | 0 | 18 | |
| GSE20123 | PKP1 | 5317 | 12 | 0 | 18 | |
| GSE43470 | PKP1 | 5317 | 6 | 0 | 37 | |
| GSE46452 | PKP1 | 5317 | 3 | 1 | 55 | |
| GSE47630 | PKP1 | 5317 | 14 | 0 | 26 | |
| GSE54993 | PKP1 | 5317 | 0 | 6 | 64 | |
| GSE54994 | PKP1 | 5317 | 15 | 0 | 38 | |
| GSE60625 | PKP1 | 5317 | 0 | 0 | 11 | |
| GSE74703 | PKP1 | 5317 | 6 | 0 | 30 | |
| GSE74704 | PKP1 | 5317 | 5 | 0 | 15 | |
| TCGA | PKP1 | 5317 | 42 | 5 | 49 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of PKP1:
Generating mutation plots.
Highly correlated genes for PKP1:
Showing top 20/455 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKP1 | KRT6C | 0.782223 | 4 | 0 | 4 |
| PKP1 | MTFP1 | 0.758157 | 3 | 0 | 3 |
| PKP1 | DSC3 | 0.747866 | 12 | 0 | 10 |
| PKP1 | DSP | 0.739599 | 11 | 0 | 11 |
| PKP1 | GPR87 | 0.734914 | 8 | 0 | 8 |
| PKP1 | LAD1 | 0.725219 | 13 | 0 | 13 |
| PKP1 | JUP | 0.724353 | 13 | 0 | 12 |
| PKP1 | FAM83H | 0.702762 | 7 | 0 | 6 |
| PKP1 | CLCA2 | 0.690396 | 11 | 0 | 9 |
| PKP1 | DSC2 | 0.686332 | 9 | 0 | 8 |
| PKP1 | NPL | 0.684521 | 3 | 0 | 3 |
| PKP1 | SFN | 0.684376 | 9 | 0 | 6 |
| PKP1 | S100A2 | 0.684251 | 10 | 0 | 8 |
| PKP1 | SDC1 | 0.675022 | 13 | 0 | 11 |
| PKP1 | TRIM29 | 0.6735 | 11 | 0 | 10 |
| PKP1 | SQLE | 0.670567 | 6 | 0 | 5 |
| PKP1 | PGLYRP3 | 0.670518 | 4 | 0 | 4 |
| PKP1 | TPM3 | 0.669323 | 4 | 0 | 3 |
| PKP1 | MRPL3 | 0.666098 | 3 | 0 | 3 |
| PKP1 | SH3RF2 | 0.666013 | 4 | 0 | 4 |
For details and further investigation, click here
