| Full name: SRY-box transcription factor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q26.33 | ||
| Entrez ID: 6657 | HGNC ID: HGNC:11195 | Ensembl Gene: ENSG00000181449 | OMIM ID: 184429 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SOX2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of SOX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX2 | 6657 | 228038_at | -1.5184 | 0.5394 | |
| GSE20347 | SOX2 | 6657 | 213721_at | -0.2721 | 0.5113 | |
| GSE23400 | SOX2 | 6657 | 213721_at | 0.2579 | 0.2337 | |
| GSE26886 | SOX2 | 6657 | 228038_at | -1.5801 | 0.0984 | |
| GSE29001 | SOX2 | 6657 | 213721_at | -0.6841 | 0.2707 | |
| GSE38129 | SOX2 | 6657 | 213721_at | 0.5465 | 0.2030 | |
| GSE45670 | SOX2 | 6657 | 228038_at | 0.1018 | 0.8448 | |
| GSE53622 | SOX2 | 6657 | 19071 | -0.3429 | 0.3002 | |
| GSE53624 | SOX2 | 6657 | 19071 | -0.4328 | 0.0340 | |
| GSE63941 | SOX2 | 6657 | 228038_at | 6.2865 | 0.0063 | |
| GSE77861 | SOX2 | 6657 | 228038_at | 0.9046 | 0.0357 | |
| GSE97050 | SOX2 | 6657 | A_23_P401055 | -0.1232 | 0.8746 | |
| SRP007169 | SOX2 | 6657 | RNAseq | 0.2138 | 0.6355 | |
| SRP008496 | SOX2 | 6657 | RNAseq | 0.3659 | 0.3892 | |
| SRP064894 | SOX2 | 6657 | RNAseq | 0.2904 | 0.5838 | |
| SRP133303 | SOX2 | 6657 | RNAseq | 0.6626 | 0.3943 | |
| SRP159526 | SOX2 | 6657 | RNAseq | 1.0635 | 0.1161 | |
| SRP193095 | SOX2 | 6657 | RNAseq | -0.2878 | 0.4350 | |
| SRP219564 | SOX2 | 6657 | RNAseq | -0.2826 | 0.7352 | |
| TCGA | SOX2 | 6657 | RNAseq | 0.4710 | 0.0920 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SOX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX2 | 6657 | 26 | 0 | 4 | |
| GSE20123 | SOX2 | 6657 | 26 | 0 | 4 | |
| GSE43470 | SOX2 | 6657 | 24 | 0 | 19 | |
| GSE46452 | SOX2 | 6657 | 19 | 1 | 39 | |
| GSE47630 | SOX2 | 6657 | 27 | 2 | 11 | |
| GSE54993 | SOX2 | 6657 | 1 | 18 | 51 | |
| GSE54994 | SOX2 | 6657 | 40 | 0 | 13 | |
| GSE60625 | SOX2 | 6657 | 0 | 6 | 5 | |
| GSE74703 | SOX2 | 6657 | 20 | 0 | 16 | |
| GSE74704 | SOX2 | 6657 | 17 | 0 | 3 | |
| TCGA | SOX2 | 6657 | 78 | 0 | 18 |
Total number of gains: 278; Total number of losses: 27; Total Number of normals: 183.
Somatic mutations of SOX2:
Generating mutation plots.
Highly correlated genes for SOX2:
Showing top 20/179 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX2 | CSTA | 0.696585 | 4 | 0 | 3 |
| SOX2 | ECI1 | 0.696267 | 4 | 0 | 4 |
| SOX2 | MFAP1 | 0.688313 | 4 | 0 | 3 |
| SOX2 | ANP32A | 0.68442 | 3 | 0 | 3 |
| SOX2 | SOX21-AS1 | 0.660268 | 6 | 0 | 6 |
| SOX2 | MAL2 | 0.657532 | 4 | 0 | 4 |
| SOX2 | CDK4 | 0.639152 | 3 | 0 | 3 |
| SOX2 | DNAJC14 | 0.627462 | 3 | 0 | 3 |
| SOX2 | SUPT4H1 | 0.627172 | 4 | 0 | 3 |
| SOX2 | WDR92 | 0.624736 | 3 | 0 | 3 |
| SOX2 | DSG3 | 0.618224 | 5 | 0 | 3 |
| SOX2 | SERPINB5 | 0.617819 | 5 | 0 | 4 |
| SOX2 | KCTD1 | 0.612387 | 5 | 0 | 5 |
| SOX2 | TP63 | 0.611304 | 5 | 0 | 4 |
| SOX2 | SERPINB13 | 0.611065 | 6 | 0 | 3 |
| SOX2 | SPRR1A | 0.609282 | 5 | 0 | 4 |
| SOX2 | ALDH3A1 | 0.608653 | 12 | 0 | 10 |
| SOX2 | ADH7 | 0.608514 | 12 | 0 | 9 |
| SOX2 | BCL11A | 0.600951 | 5 | 0 | 3 |
| SOX2 | NFE2L2 | 0.600911 | 9 | 0 | 7 |
For details and further investigation, click here
