FZD1

 

Full name: frizzled class receptor 1 Alias Symbol: DKFZp564G072
Type: protein-coding gene Cytoband: 7q21.13
Entrez ID: 8321 HGNC ID: HGNC:4038 Ensembl Gene: ENSG00000157240 OMIM ID: 603408
Drug and gene relationship at DGIdb

 

FZD1 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of FZD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FZD1 8321 204451_at -0.1904 0.7262
GSE20347 FZD1 8321 204451_at 0.6339 0.0560
GSE23400 FZD1 8321 204452_s_at 0.1090 0.0188
GSE26886 FZD1 8321 204451_at 0.1273 0.6275
GSE29001 FZD1 8321 204451_at 0.3988 0.1236
GSE38129 FZD1 8321 204451_at 0.5935 0.0054
GSE45670 FZD1 8321 204451_at -0.1346 0.6756
GSE53622 FZD1 8321 12390 0.9013 0.0000
GSE53624 FZD1 8321 12390 0.5632 0.0000
GSE63941 FZD1 8321 204451_at -2.1103 0.0160
GSE77861 FZD1 8321 204451_at 0.3048 0.6147
GSE97050 FZD1 8321 A_24_P38276 0.5543 0.3667
SRP007169 FZD1 8321 RNAseq 0.4512 0.2387
SRP008496 FZD1 8321 RNAseq 0.8625 0.0030
SRP064894 FZD1 8321 RNAseq 0.7530 0.0016
SRP133303 FZD1 8321 RNAseq 1.3677 0.0009
SRP159526 FZD1 8321 RNAseq 1.3326 0.0152
SRP193095 FZD1 8321 RNAseq 0.7288 0.0006
SRP219564 FZD1 8321 RNAseq 0.8690 0.0771
TCGA FZD1 8321 RNAseq 0.1470 0.0727

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by FZD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FZD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FZD1 8321 13 0 17
GSE20123 FZD1 8321 13 0 17
GSE43470 FZD1 8321 6 1 36
GSE46452 FZD1 8321 11 0 48
GSE47630 FZD1 8321 9 2 29
GSE54993 FZD1 8321 1 8 61
GSE54994 FZD1 8321 16 2 35
GSE60625 FZD1 8321 0 0 11
GSE74703 FZD1 8321 5 1 30
GSE74704 FZD1 8321 9 0 11
TCGA FZD1 8321 56 4 36

Total number of gains: 139; Total number of losses: 18; Total Number of normals: 331.  

 

Somatic mutations of FZD1:

 

Generating mutation plots.

 

Highly correlated genes for FZD1:

 

Showing top 20/349 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FZD1GPHN0.745578303
FZD1TNFRSF10D0.725761303
FZD1ADAM90.718313303
FZD1CLDN120.692253503
FZD1F13A10.685565303
FZD1PPM1D0.675987303
FZD1STOML10.672388303
FZD1CCNY0.666887303
FZD1SPON20.662262303
FZD1ABHD20.65735303
FZD1PPFIBP10.657039403
FZD1SLC39A100.654632404
FZD1ST6GAL10.645812403
FZD1SCMH10.642949303
FZD1FNDC10.642842404
FZD1SH3RF30.642183403
FZD1LRRC590.641851303
FZD1SLC35E30.634287403
FZD1COL8A10.634213604
FZD1TK20.633816303

For details and further investigation, click here