| Full name: iodothyronine deiodinase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 1733 | HGNC ID: HGNC:2883 | Ensembl Gene: ENSG00000211452 | OMIM ID: 147892 |
| Drug and gene relationship at DGIdb | |||
Expression of DIO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIO1 | 1733 | 206457_s_at | -0.3518 | 0.2009 | |
| GSE20347 | DIO1 | 1733 | 206457_s_at | -0.0633 | 0.3632 | |
| GSE23400 | DIO1 | 1733 | 206457_s_at | -0.1302 | 0.0000 | |
| GSE26886 | DIO1 | 1733 | 206457_s_at | -0.2934 | 0.0129 | |
| GSE29001 | DIO1 | 1733 | 206457_s_at | -0.1709 | 0.3206 | |
| GSE38129 | DIO1 | 1733 | 206457_s_at | -0.0874 | 0.1347 | |
| GSE45670 | DIO1 | 1733 | 206457_s_at | -0.0695 | 0.4766 | |
| GSE53622 | DIO1 | 1733 | 84128 | -0.8722 | 0.0000 | |
| GSE53624 | DIO1 | 1733 | 84128 | -1.7925 | 0.0000 | |
| GSE63941 | DIO1 | 1733 | 206457_s_at | 0.1478 | 0.5719 | |
| GSE77861 | DIO1 | 1733 | 206457_s_at | -0.0771 | 0.3531 | |
| GSE97050 | DIO1 | 1733 | A_23_P45811 | 0.0477 | 0.8243 | |
| SRP133303 | DIO1 | 1733 | RNAseq | -0.1361 | 0.6907 | |
| TCGA | DIO1 | 1733 | RNAseq | -0.2198 | 0.5436 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DIO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIO1 | 1733 | 3 | 4 | 23 | |
| GSE20123 | DIO1 | 1733 | 3 | 3 | 24 | |
| GSE43470 | DIO1 | 1733 | 6 | 2 | 35 | |
| GSE46452 | DIO1 | 1733 | 2 | 1 | 56 | |
| GSE47630 | DIO1 | 1733 | 8 | 4 | 28 | |
| GSE54993 | DIO1 | 1733 | 0 | 0 | 70 | |
| GSE54994 | DIO1 | 1733 | 10 | 2 | 41 | |
| GSE60625 | DIO1 | 1733 | 0 | 0 | 11 | |
| GSE74703 | DIO1 | 1733 | 4 | 1 | 31 | |
| GSE74704 | DIO1 | 1733 | 2 | 0 | 18 | |
| TCGA | DIO1 | 1733 | 10 | 18 | 68 |
Total number of gains: 48; Total number of losses: 35; Total Number of normals: 405.
Somatic mutations of DIO1:
Generating mutation plots.
Highly correlated genes for DIO1:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIO1 | PIP | 0.676407 | 3 | 0 | 3 |
| DIO1 | ELSPBP1 | 0.65647 | 3 | 0 | 3 |
| DIO1 | TMEM254 | 0.643773 | 4 | 0 | 4 |
| DIO1 | SLC46A2 | 0.642199 | 6 | 0 | 5 |
| DIO1 | TFF1 | 0.635943 | 3 | 0 | 3 |
| DIO1 | PDZK1 | 0.633939 | 3 | 0 | 3 |
| DIO1 | CCDC70 | 0.630258 | 3 | 0 | 3 |
| DIO1 | PADI4 | 0.627978 | 3 | 0 | 3 |
| DIO1 | KLB | 0.624334 | 6 | 0 | 5 |
| DIO1 | GK2 | 0.621951 | 3 | 0 | 3 |
| DIO1 | ABCB4 | 0.615129 | 5 | 0 | 4 |
| DIO1 | SPX | 0.612425 | 3 | 0 | 3 |
| DIO1 | DEGS2 | 0.611419 | 6 | 0 | 5 |
| DIO1 | PDE6G | 0.609736 | 4 | 0 | 3 |
| DIO1 | FNDC8 | 0.608813 | 3 | 0 | 3 |
| DIO1 | LGI1 | 0.60866 | 4 | 0 | 3 |
| DIO1 | MTPN | 0.606918 | 3 | 0 | 3 |
| DIO1 | PRDM11 | 0.604195 | 3 | 0 | 3 |
| DIO1 | BNIPL | 0.60178 | 5 | 0 | 3 |
| DIO1 | TCP11L2 | 0.598558 | 5 | 0 | 4 |
For details and further investigation, click here
