NRAS

 

Full name: NRAS proto-oncogene, GTPase Alias Symbol: N-ras
Type: protein-coding gene Cytoband: 1p13.2
Entrez ID: 4893 HGNC ID: HGNC:7989 Ensembl Gene: ENSG00000213281 OMIM ID: 164790
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 31/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

NRAS involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04530Tight junction
hsa04540Gap junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05034Alcoholism
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of NRAS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NRAS 4893 224985_at 0.1195 0.8823
GSE20347 NRAS 4893 202647_s_at 0.1422 0.6073
GSE23400 NRAS 4893 202647_s_at 0.4664 0.0000
GSE26886 NRAS 4893 224985_at -0.3537 0.0304
GSE29001 NRAS 4893 202647_s_at 0.1317 0.7436
GSE38129 NRAS 4893 202647_s_at 0.5086 0.0155
GSE45670 NRAS 4893 224985_at 0.2529 0.0497
GSE53622 NRAS 4893 10919 0.4486 0.0000
GSE53624 NRAS 4893 10919 0.3755 0.0000
GSE63941 NRAS 4893 224985_at 0.1194 0.8572
GSE77861 NRAS 4893 224985_at -0.2591 0.1964
GSE97050 NRAS 4893 A_33_P3317825 0.6427 0.2204
SRP007169 NRAS 4893 RNAseq -0.2435 0.5060
SRP008496 NRAS 4893 RNAseq -0.2307 0.2579
SRP064894 NRAS 4893 RNAseq 0.1154 0.5856
SRP133303 NRAS 4893 RNAseq 0.5090 0.0085
SRP159526 NRAS 4893 RNAseq -0.5229 0.0307
SRP193095 NRAS 4893 RNAseq -0.1196 0.3770
SRP219564 NRAS 4893 RNAseq -0.0415 0.9460
TCGA NRAS 4893 RNAseq 0.1475 0.0049

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NRAS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NRAS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NRAS 4893 0 9 21
GSE20123 NRAS 4893 0 9 21
GSE43470 NRAS 4893 0 8 35
GSE46452 NRAS 4893 2 1 56
GSE47630 NRAS 4893 9 5 26
GSE54993 NRAS 4893 0 1 69
GSE54994 NRAS 4893 7 3 43
GSE60625 NRAS 4893 0 0 11
GSE74703 NRAS 4893 0 7 29
GSE74704 NRAS 4893 0 5 15
TCGA NRAS 4893 12 30 54

Total number of gains: 30; Total number of losses: 78; Total Number of normals: 380.  

 

Somatic mutations of NRAS:

 

Generating mutation plots.

 

Highly correlated genes for NRAS:

 

Showing top 20/434 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NRASTRIB30.735328404
NRASTMEM540.715016303
NRASGALE0.697015303
NRASFAM83B0.689746505
NRASAMPD30.669635404
NRASSPAG10.658007504
NRASGSTO20.655186303
NRASAJUBA0.654998403
NRASWNT10A0.654841403
NRASETV40.650786503
NRASMYSM10.647144303
NRASSPHK10.640589504
NRASIL1RAP0.632524907
NRASEPHA20.632328403
NRASVAV30.631615303
NRASGJB30.631406604
NRASIRAK20.628227403
NRASCNIH10.628007504
NRASOLFM20.62584303
NRASSRP90.62443303

For details and further investigation, click here