| Full name: sphingosine kinase 1 | Alias Symbol: SPHK | ||
| Type: protein-coding gene | Cytoband: 17q25.2 | ||
| Entrez ID: 8877 | HGNC ID: HGNC:11240 | Ensembl Gene: ENSG00000176170 | OMIM ID: 603730 |
| Drug and gene relationship at DGIdb | |||
SPHK1 involved pathways:
Expression of SPHK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPHK1 | 8877 | 219257_s_at | 0.3906 | 0.5186 | |
| GSE20347 | SPHK1 | 8877 | 219257_s_at | 0.6315 | 0.0051 | |
| GSE23400 | SPHK1 | 8877 | 219257_s_at | 0.4612 | 0.0000 | |
| GSE26886 | SPHK1 | 8877 | 219257_s_at | -0.6231 | 0.1605 | |
| GSE29001 | SPHK1 | 8877 | 219257_s_at | 0.0592 | 0.9186 | |
| GSE38129 | SPHK1 | 8877 | 219257_s_at | 0.8459 | 0.0000 | |
| GSE45670 | SPHK1 | 8877 | 219257_s_at | 0.4769 | 0.0426 | |
| GSE63941 | SPHK1 | 8877 | 219257_s_at | -0.4305 | 0.4646 | |
| GSE77861 | SPHK1 | 8877 | 219257_s_at | 0.4055 | 0.1396 | |
| GSE97050 | SPHK1 | 8877 | A_33_P3222069 | 0.7281 | 0.2422 | |
| SRP007169 | SPHK1 | 8877 | RNAseq | 0.1297 | 0.7977 | |
| SRP008496 | SPHK1 | 8877 | RNAseq | -0.1033 | 0.7334 | |
| SRP064894 | SPHK1 | 8877 | RNAseq | 0.5740 | 0.0337 | |
| SRP133303 | SPHK1 | 8877 | RNAseq | 1.0143 | 0.0009 | |
| SRP159526 | SPHK1 | 8877 | RNAseq | 1.5064 | 0.0286 | |
| SRP193095 | SPHK1 | 8877 | RNAseq | 1.0457 | 0.0012 | |
| SRP219564 | SPHK1 | 8877 | RNAseq | 0.0046 | 0.9900 | |
| TCGA | SPHK1 | 8877 | RNAseq | 0.6902 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SPHK1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SPHK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPHK1 | 8877 | 7 | 2 | 21 | |
| GSE20123 | SPHK1 | 8877 | 7 | 2 | 21 | |
| GSE43470 | SPHK1 | 8877 | 5 | 3 | 35 | |
| GSE46452 | SPHK1 | 8877 | 34 | 0 | 25 | |
| GSE47630 | SPHK1 | 8877 | 8 | 1 | 31 | |
| GSE54993 | SPHK1 | 8877 | 2 | 5 | 63 | |
| GSE54994 | SPHK1 | 8877 | 10 | 4 | 39 | |
| GSE60625 | SPHK1 | 8877 | 6 | 0 | 5 | |
| GSE74703 | SPHK1 | 8877 | 5 | 1 | 30 | |
| GSE74704 | SPHK1 | 8877 | 5 | 1 | 14 | |
| TCGA | SPHK1 | 8877 | 31 | 10 | 55 |
Total number of gains: 120; Total number of losses: 29; Total Number of normals: 339.
Somatic mutations of SPHK1:
Generating mutation plots.
Highly correlated genes for SPHK1:
Showing top 20/399 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPHK1 | FAM83B | 0.740001 | 3 | 0 | 3 |
| SPHK1 | TNKS1BP1 | 0.707797 | 3 | 0 | 3 |
| SPHK1 | EME1 | 0.701579 | 3 | 0 | 3 |
| SPHK1 | ZDHHC9 | 0.691093 | 4 | 0 | 4 |
| SPHK1 | RTN4R | 0.674182 | 3 | 0 | 3 |
| SPHK1 | MRC1 | 0.666775 | 3 | 0 | 3 |
| SPHK1 | SOX15 | 0.658885 | 4 | 0 | 4 |
| SPHK1 | SLC37A2 | 0.654346 | 3 | 0 | 3 |
| SPHK1 | ESCO2 | 0.653312 | 3 | 0 | 3 |
| SPHK1 | ARNTL2 | 0.653069 | 4 | 0 | 3 |
| SPHK1 | KPNA2 | 0.648707 | 7 | 0 | 5 |
| SPHK1 | HYAL2 | 0.64848 | 3 | 0 | 3 |
| SPHK1 | TTYH3 | 0.647509 | 4 | 0 | 3 |
| SPHK1 | NRG1 | 0.644401 | 4 | 0 | 3 |
| SPHK1 | CHI3L1 | 0.641517 | 5 | 0 | 5 |
| SPHK1 | GINS3 | 0.641366 | 4 | 0 | 4 |
| SPHK1 | NRAS | 0.640589 | 5 | 0 | 4 |
| SPHK1 | PIGW | 0.635644 | 4 | 0 | 3 |
| SPHK1 | AP2S1 | 0.635329 | 4 | 0 | 3 |
| SPHK1 | NAGS | 0.635192 | 3 | 0 | 3 |
For details and further investigation, click here
