| Full name: NSE1 homolog, SMC5-SMC6 complex component | Alias Symbol: NSE1 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 197370 | HGNC ID: HGNC:29897 | Ensembl Gene: ENSG00000169189 | OMIM ID: 617263 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NSMCE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSMCE1 | 197370 | 224666_at | -0.0602 | 0.9200 | |
| GSE26886 | NSMCE1 | 197370 | 224666_at | 0.4193 | 0.0059 | |
| GSE45670 | NSMCE1 | 197370 | 224666_at | 0.1115 | 0.3597 | |
| GSE53622 | NSMCE1 | 197370 | 75764 | 0.0558 | 0.3420 | |
| GSE53624 | NSMCE1 | 197370 | 75764 | 0.3744 | 0.0000 | |
| GSE63941 | NSMCE1 | 197370 | 224666_at | -0.2380 | 0.6263 | |
| GSE77861 | NSMCE1 | 197370 | 224666_at | -0.1329 | 0.5034 | |
| GSE97050 | NSMCE1 | 197370 | A_23_P95823 | -0.3077 | 0.3688 | |
| SRP007169 | NSMCE1 | 197370 | RNAseq | -0.5890 | 0.0990 | |
| SRP008496 | NSMCE1 | 197370 | RNAseq | -0.7161 | 0.0011 | |
| SRP064894 | NSMCE1 | 197370 | RNAseq | -0.2261 | 0.4002 | |
| SRP133303 | NSMCE1 | 197370 | RNAseq | 0.1083 | 0.5950 | |
| SRP159526 | NSMCE1 | 197370 | RNAseq | -0.1274 | 0.4923 | |
| SRP193095 | NSMCE1 | 197370 | RNAseq | -0.0518 | 0.7026 | |
| SRP219564 | NSMCE1 | 197370 | RNAseq | -0.0657 | 0.8802 | |
| TCGA | NSMCE1 | 197370 | RNAseq | 0.0016 | 0.9787 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NSMCE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NSMCE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSMCE1 | 197370 | 4 | 5 | 21 | |
| GSE20123 | NSMCE1 | 197370 | 4 | 4 | 22 | |
| GSE43470 | NSMCE1 | 197370 | 4 | 3 | 36 | |
| GSE46452 | NSMCE1 | 197370 | 38 | 1 | 20 | |
| GSE47630 | NSMCE1 | 197370 | 12 | 6 | 22 | |
| GSE54993 | NSMCE1 | 197370 | 3 | 5 | 62 | |
| GSE54994 | NSMCE1 | 197370 | 4 | 9 | 40 | |
| GSE60625 | NSMCE1 | 197370 | 4 | 0 | 7 | |
| GSE74703 | NSMCE1 | 197370 | 4 | 2 | 30 | |
| GSE74704 | NSMCE1 | 197370 | 2 | 2 | 16 | |
| TCGA | NSMCE1 | 197370 | 19 | 12 | 65 |
Total number of gains: 98; Total number of losses: 49; Total Number of normals: 341.
Somatic mutations of NSMCE1:
Generating mutation plots.
Highly correlated genes for NSMCE1:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSMCE1 | LANCL1 | 0.788544 | 3 | 0 | 3 |
| NSMCE1 | COX10 | 0.73198 | 3 | 0 | 3 |
| NSMCE1 | ROGDI | 0.726672 | 3 | 0 | 3 |
| NSMCE1 | METTL9 | 0.72336 | 3 | 0 | 3 |
| NSMCE1 | NDUFV1 | 0.719936 | 3 | 0 | 3 |
| NSMCE1 | N6AMT1 | 0.712248 | 3 | 0 | 3 |
| NSMCE1 | RTF1 | 0.711468 | 3 | 0 | 3 |
| NSMCE1 | PRADC1 | 0.710578 | 3 | 0 | 3 |
| NSMCE1 | ZNF12 | 0.709481 | 3 | 0 | 3 |
| NSMCE1 | RAC1 | 0.699393 | 3 | 0 | 3 |
| NSMCE1 | TCHP | 0.698013 | 3 | 0 | 3 |
| NSMCE1 | COG1 | 0.69388 | 3 | 0 | 3 |
| NSMCE1 | TCEANC2 | 0.685056 | 3 | 0 | 3 |
| NSMCE1 | TXNDC11 | 0.681781 | 3 | 0 | 3 |
| NSMCE1 | FOXN3 | 0.681342 | 3 | 0 | 3 |
| NSMCE1 | VPS18 | 0.677495 | 3 | 0 | 3 |
| NSMCE1 | ZNF558 | 0.675977 | 3 | 0 | 3 |
| NSMCE1 | LMBRD2 | 0.675361 | 3 | 0 | 3 |
| NSMCE1 | PPM1L | 0.671984 | 3 | 0 | 3 |
| NSMCE1 | METTL23 | 0.668607 | 3 | 0 | 3 |
For details and further investigation, click here
