| Full name: netrin 1 | Alias Symbol: NTN1L | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 9423 | HGNC ID: HGNC:8029 | Ensembl Gene: ENSG00000065320 | OMIM ID: 601614 |
| Drug and gene relationship at DGIdb | |||
NTN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of NTN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NTN1 | 9423 | 227816_at | -1.1493 | 0.1328 | |
| GSE20347 | NTN1 | 9423 | 208005_at | -0.1644 | 0.0256 | |
| GSE23400 | NTN1 | 9423 | 208005_at | -0.0704 | 0.1321 | |
| GSE26886 | NTN1 | 9423 | 227816_at | -0.4940 | 0.0879 | |
| GSE29001 | NTN1 | 9423 | 208005_at | -0.2488 | 0.0568 | |
| GSE38129 | NTN1 | 9423 | 208005_at | -0.1265 | 0.0244 | |
| GSE45670 | NTN1 | 9423 | 227816_at | -1.1303 | 0.0000 | |
| GSE53622 | NTN1 | 9423 | 23876 | -1.1847 | 0.0000 | |
| GSE53624 | NTN1 | 9423 | 23876 | -1.3941 | 0.0000 | |
| GSE63941 | NTN1 | 9423 | 227816_at | 1.0827 | 0.1712 | |
| GSE77861 | NTN1 | 9423 | 227816_at | -0.7091 | 0.0358 | |
| GSE97050 | NTN1 | 9423 | A_32_P53524 | -1.4414 | 0.1389 | |
| SRP007169 | NTN1 | 9423 | RNAseq | -0.0327 | 0.9642 | |
| SRP064894 | NTN1 | 9423 | RNAseq | -0.9613 | 0.0000 | |
| SRP133303 | NTN1 | 9423 | RNAseq | -0.8440 | 0.0182 | |
| SRP159526 | NTN1 | 9423 | RNAseq | -1.1387 | 0.0010 | |
| SRP193095 | NTN1 | 9423 | RNAseq | -0.1316 | 0.5359 | |
| TCGA | NTN1 | 9423 | RNAseq | -0.5146 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by NTN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NTN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NTN1 | 9423 | 3 | 3 | 24 | |
| GSE20123 | NTN1 | 9423 | 3 | 4 | 23 | |
| GSE43470 | NTN1 | 9423 | 2 | 6 | 35 | |
| GSE46452 | NTN1 | 9423 | 34 | 1 | 24 | |
| GSE47630 | NTN1 | 9423 | 7 | 1 | 32 | |
| GSE54993 | NTN1 | 9423 | 4 | 3 | 63 | |
| GSE54994 | NTN1 | 9423 | 5 | 8 | 40 | |
| GSE60625 | NTN1 | 9423 | 4 | 0 | 7 | |
| GSE74703 | NTN1 | 9423 | 2 | 3 | 31 | |
| GSE74704 | NTN1 | 9423 | 1 | 2 | 17 | |
| TCGA | NTN1 | 9423 | 17 | 21 | 58 |
Total number of gains: 82; Total number of losses: 52; Total Number of normals: 354.
Somatic mutations of NTN1:
Generating mutation plots.
Highly correlated genes for NTN1:
Showing top 20/965 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NTN1 | PPP1R12B | 0.82506 | 5 | 0 | 5 |
| NTN1 | DAAM2 | 0.800811 | 3 | 0 | 3 |
| NTN1 | AOC3 | 0.780228 | 5 | 0 | 5 |
| NTN1 | CYP21A2 | 0.772326 | 3 | 0 | 3 |
| NTN1 | SORCS1 | 0.770437 | 4 | 0 | 4 |
| NTN1 | ANGPTL1 | 0.768392 | 5 | 0 | 5 |
| NTN1 | SCN7A | 0.763574 | 6 | 0 | 6 |
| NTN1 | GSN | 0.762773 | 5 | 0 | 5 |
| NTN1 | RBPMS2 | 0.75626 | 5 | 0 | 5 |
| NTN1 | OGN | 0.753603 | 5 | 0 | 5 |
| NTN1 | CLEC3B | 0.753157 | 3 | 0 | 3 |
| NTN1 | PLAC9 | 0.751459 | 6 | 0 | 6 |
| NTN1 | CBX7 | 0.750884 | 5 | 0 | 5 |
| NTN1 | RAB9B | 0.745826 | 5 | 0 | 5 |
| NTN1 | TMOD1 | 0.743005 | 3 | 0 | 3 |
| NTN1 | PLN | 0.74211 | 5 | 0 | 5 |
| NTN1 | ATP1A2 | 0.740855 | 6 | 0 | 5 |
| NTN1 | ADAMTS9-AS2 | 0.734102 | 4 | 0 | 4 |
| NTN1 | ZNF287 | 0.72625 | 3 | 0 | 3 |
| NTN1 | LDB3 | 0.724167 | 5 | 0 | 4 |
For details and further investigation, click here
