| Full name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Alias Symbol: KIAA1556|UNC89|KIAA1639|ARHGEF30 | ||
| Type: protein-coding gene | Cytoband: 1q42.13 | ||
| Entrez ID: 84033 | HGNC ID: HGNC:15719 | Ensembl Gene: ENSG00000154358 | OMIM ID: 608616 |
| Drug and gene relationship at DGIdb | |||
Expression of OBSCN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OBSCN | 84033 | 220427_at | 0.1979 | 0.2698 | |
| GSE20347 | OBSCN | 84033 | 220427_at | -0.0118 | 0.8898 | |
| GSE23400 | OBSCN | 84033 | 220427_at | -0.0459 | 0.1254 | |
| GSE26886 | OBSCN | 84033 | 220427_at | 0.3907 | 0.0008 | |
| GSE29001 | OBSCN | 84033 | 220427_at | -0.0330 | 0.8399 | |
| GSE38129 | OBSCN | 84033 | 220427_at | -0.0001 | 0.9990 | |
| GSE45670 | OBSCN | 84033 | 220427_at | 0.2785 | 0.0011 | |
| GSE53622 | OBSCN | 84033 | 55870 | 0.4138 | 0.0022 | |
| GSE53624 | OBSCN | 84033 | 55870 | 0.4946 | 0.0000 | |
| GSE63941 | OBSCN | 84033 | 220427_at | 0.3565 | 0.2203 | |
| GSE77861 | OBSCN | 84033 | 220427_at | 0.0509 | 0.7352 | |
| GSE97050 | OBSCN | 84033 | A_24_P273157 | -0.6449 | 0.0952 | |
| SRP007169 | OBSCN | 84033 | RNAseq | 1.9857 | 0.0022 | |
| SRP064894 | OBSCN | 84033 | RNAseq | 0.3098 | 0.3274 | |
| SRP133303 | OBSCN | 84033 | RNAseq | -0.4362 | 0.1189 | |
| SRP159526 | OBSCN | 84033 | RNAseq | -0.1855 | 0.6581 | |
| SRP193095 | OBSCN | 84033 | RNAseq | 0.7689 | 0.0012 | |
| SRP219564 | OBSCN | 84033 | RNAseq | 0.0525 | 0.9089 | |
| TCGA | OBSCN | 84033 | RNAseq | 0.1061 | 0.2497 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by OBSCN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OBSCN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OBSCN | 84033 | 11 | 0 | 19 | |
| GSE20123 | OBSCN | 84033 | 11 | 0 | 19 | |
| GSE43470 | OBSCN | 84033 | 7 | 1 | 35 | |
| GSE46452 | OBSCN | 84033 | 4 | 2 | 53 | |
| GSE47630 | OBSCN | 84033 | 15 | 0 | 25 | |
| GSE54993 | OBSCN | 84033 | 0 | 6 | 64 | |
| GSE54994 | OBSCN | 84033 | 17 | 0 | 36 | |
| GSE60625 | OBSCN | 84033 | 0 | 0 | 11 | |
| GSE74703 | OBSCN | 84033 | 7 | 1 | 28 | |
| GSE74704 | OBSCN | 84033 | 5 | 0 | 15 | |
| TCGA | OBSCN | 84033 | 45 | 2 | 49 |
Total number of gains: 122; Total number of losses: 12; Total Number of normals: 354.
Somatic mutations of OBSCN:
Generating mutation plots.
Highly correlated genes for OBSCN:
Showing top 20/379 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OBSCN | PDLIM4 | 0.694138 | 4 | 0 | 3 |
| OBSCN | TGS1 | 0.691128 | 3 | 0 | 3 |
| OBSCN | CCDC106 | 0.682702 | 3 | 0 | 3 |
| OBSCN | OCIAD2 | 0.677727 | 3 | 0 | 3 |
| OBSCN | MRPL36 | 0.673351 | 3 | 0 | 3 |
| OBSCN | NCSTN | 0.658294 | 4 | 0 | 4 |
| OBSCN | SLC25A53 | 0.654285 | 4 | 0 | 4 |
| OBSCN | CRYBA1 | 0.653018 | 4 | 0 | 4 |
| OBSCN | GRASP | 0.650984 | 3 | 0 | 3 |
| OBSCN | SPEG | 0.647236 | 3 | 0 | 3 |
| OBSCN | GSX1 | 0.646631 | 3 | 0 | 3 |
| OBSCN | APOBEC3B | 0.646281 | 3 | 0 | 3 |
| OBSCN | TRAPPC3L | 0.644743 | 3 | 0 | 3 |
| OBSCN | SZT2 | 0.643744 | 5 | 0 | 5 |
| OBSCN | CDK20 | 0.640033 | 5 | 0 | 4 |
| OBSCN | CD4 | 0.638082 | 3 | 0 | 3 |
| OBSCN | RTKN | 0.636715 | 4 | 0 | 3 |
| OBSCN | MAPRE3 | 0.636276 | 6 | 0 | 5 |
| OBSCN | ABHD8 | 0.633936 | 4 | 0 | 3 |
| OBSCN | PRX | 0.633359 | 5 | 0 | 4 |
For details and further investigation, click here
