| Full name: OTU deubiquitinase 4 | Alias Symbol: HSHIN1|KIAA1046|DUBA6 | ||
| Type: protein-coding gene | Cytoband: 4q31.21 | ||
| Entrez ID: 54726 | HGNC ID: HGNC:24949 | Ensembl Gene: ENSG00000164164 | OMIM ID: 611744 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of OTUD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OTUD4 | 54726 | 203480_s_at | 0.4368 | 0.2080 | |
| GSE20347 | OTUD4 | 54726 | 203480_s_at | -0.2592 | 0.0046 | |
| GSE23400 | OTUD4 | 54726 | 203480_s_at | 0.0536 | 0.3207 | |
| GSE26886 | OTUD4 | 54726 | 203480_s_at | 0.0793 | 0.6527 | |
| GSE29001 | OTUD4 | 54726 | 203480_s_at | 0.1710 | 0.2272 | |
| GSE38129 | OTUD4 | 54726 | 203480_s_at | -0.2272 | 0.0121 | |
| GSE45670 | OTUD4 | 54726 | 203480_s_at | -0.0831 | 0.4566 | |
| GSE53622 | OTUD4 | 54726 | 105967 | -0.0913 | 0.2710 | |
| GSE53624 | OTUD4 | 54726 | 105967 | -0.1923 | 0.0180 | |
| GSE63941 | OTUD4 | 54726 | 203480_s_at | -0.7077 | 0.0285 | |
| GSE77861 | OTUD4 | 54726 | 203480_s_at | -0.1943 | 0.3846 | |
| GSE97050 | OTUD4 | 54726 | A_23_P69637 | 0.2153 | 0.4810 | |
| SRP007169 | OTUD4 | 54726 | RNAseq | 0.5485 | 0.2450 | |
| SRP008496 | OTUD4 | 54726 | RNAseq | 0.4842 | 0.1169 | |
| SRP064894 | OTUD4 | 54726 | RNAseq | -0.0066 | 0.9806 | |
| SRP133303 | OTUD4 | 54726 | RNAseq | 0.4460 | 0.0027 | |
| SRP159526 | OTUD4 | 54726 | RNAseq | -0.0300 | 0.8935 | |
| SRP193095 | OTUD4 | 54726 | RNAseq | 0.0486 | 0.6358 | |
| SRP219564 | OTUD4 | 54726 | RNAseq | -0.1094 | 0.6900 | |
| TCGA | OTUD4 | 54726 | RNAseq | 0.0574 | 0.2295 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by OTUD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OTUD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OTUD4 | 54726 | 0 | 13 | 17 | |
| GSE20123 | OTUD4 | 54726 | 0 | 13 | 17 | |
| GSE43470 | OTUD4 | 54726 | 0 | 13 | 30 | |
| GSE46452 | OTUD4 | 54726 | 1 | 36 | 22 | |
| GSE47630 | OTUD4 | 54726 | 0 | 22 | 18 | |
| GSE54993 | OTUD4 | 54726 | 10 | 0 | 60 | |
| GSE54994 | OTUD4 | 54726 | 2 | 11 | 40 | |
| GSE60625 | OTUD4 | 54726 | 0 | 1 | 10 | |
| GSE74703 | OTUD4 | 54726 | 0 | 11 | 25 | |
| GSE74704 | OTUD4 | 54726 | 0 | 7 | 13 | |
| TCGA | OTUD4 | 54726 | 11 | 33 | 52 |
Total number of gains: 24; Total number of losses: 160; Total Number of normals: 304.
Somatic mutations of OTUD4:
Generating mutation plots.
Highly correlated genes for OTUD4:
Showing top 20/38 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OTUD4 | ZNF283 | 0.786342 | 3 | 0 | 3 |
| OTUD4 | HIVEP2 | 0.782591 | 3 | 0 | 3 |
| OTUD4 | SOX30 | 0.776561 | 3 | 0 | 3 |
| OTUD4 | CHI3L2 | 0.672105 | 3 | 0 | 3 |
| OTUD4 | IL12RB2 | 0.660572 | 4 | 0 | 3 |
| OTUD4 | ING5 | 0.650295 | 3 | 0 | 3 |
| OTUD4 | HES2 | 0.640531 | 3 | 0 | 3 |
| OTUD4 | TRIM55 | 0.637167 | 3 | 0 | 3 |
| OTUD4 | DCAF4 | 0.616127 | 4 | 0 | 3 |
| OTUD4 | MAST4 | 0.606692 | 5 | 0 | 3 |
| OTUD4 | CLDN23 | 0.604892 | 4 | 0 | 3 |
| OTUD4 | RBM25 | 0.604205 | 4 | 0 | 3 |
| OTUD4 | NCKAP5 | 0.603111 | 4 | 0 | 3 |
| OTUD4 | TSR1 | 0.594396 | 5 | 0 | 3 |
| OTUD4 | RGS12 | 0.594066 | 6 | 0 | 3 |
| OTUD4 | PGF | 0.593825 | 5 | 0 | 3 |
| OTUD4 | C1orf52 | 0.581114 | 4 | 0 | 3 |
| OTUD4 | GMFB | 0.580111 | 3 | 0 | 3 |
| OTUD4 | HRK | 0.573137 | 4 | 0 | 3 |
| OTUD4 | CXorf21 | 0.556308 | 6 | 0 | 3 |
For details and further investigation, click here
