GMFB

 

Full name: glia maturation factor beta Alias Symbol: GMF
Type: protein-coding gene Cytoband: 14q22.2
Entrez ID: 2764 HGNC ID: HGNC:4373 Ensembl Gene: ENSG00000197045 OMIM ID: 601713
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GMFB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GMFB 2764 202544_at 0.6448 0.0872
GSE20347 GMFB 2764 202544_at 0.2693 0.0253
GSE23400 GMFB 2764 202544_at 0.5196 0.0000
GSE26886 GMFB 2764 202544_at 0.1107 0.4398
GSE29001 GMFB 2764 202543_s_at 0.3031 0.3608
GSE38129 GMFB 2764 202544_at 0.3116 0.0008
GSE45670 GMFB 2764 202544_at 0.3645 0.0095
GSE53622 GMFB 2764 38350 0.5590 0.0000
GSE53624 GMFB 2764 38350 0.5257 0.0000
GSE63941 GMFB 2764 202543_s_at 0.9589 0.0313
GSE77861 GMFB 2764 202544_at 0.2796 0.5395
GSE97050 GMFB 2764 A_23_P205611 0.5360 0.1978
SRP007169 GMFB 2764 RNAseq 0.1747 0.6203
SRP008496 GMFB 2764 RNAseq 0.2870 0.1340
SRP064894 GMFB 2764 RNAseq 0.3530 0.1347
SRP133303 GMFB 2764 RNAseq 0.7225 0.0007
SRP159526 GMFB 2764 RNAseq 0.1438 0.5219
SRP193095 GMFB 2764 RNAseq 0.0971 0.5550
SRP219564 GMFB 2764 RNAseq 0.5909 0.1869
TCGA GMFB 2764 RNAseq 0.0693 0.1718

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GMFB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GMFB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GMFB 2764 8 3 19
GSE20123 GMFB 2764 8 3 19
GSE43470 GMFB 2764 9 1 33
GSE46452 GMFB 2764 16 3 40
GSE47630 GMFB 2764 11 10 19
GSE54993 GMFB 2764 3 8 59
GSE54994 GMFB 2764 19 4 30
GSE60625 GMFB 2764 0 2 9
GSE74703 GMFB 2764 8 1 27
GSE74704 GMFB 2764 3 2 15
TCGA GMFB 2764 33 13 50

Total number of gains: 118; Total number of losses: 50; Total Number of normals: 320.  

 

Somatic mutations of GMFB:

 

Generating mutation plots.

 

Highly correlated genes for GMFB:

 

Showing top 20/655 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GMFBSMARCAD10.75779303
GMFBDNAJC90.74066404
GMFBJKAMP0.717658606
GMFBUHRF10.710395404
GMFBTXNDC120.704386606
GMFBLRR10.686844707
GMFBZC3HC10.681703404
GMFBCDKN30.662787908
GMFBSMC30.661049505
GMFBC4orf460.660557403
GMFBPSMA30.6587611008
GMFBCKAP2L0.657839404
GMFBGNPNAT10.654347504
GMFBFANCM0.653754504
GMFBMTHFD10.6530421008
GMFBGPX70.651667303
GMFBBEND30.649453505
GMFBMAD2L20.649406504
GMFBSH2D50.649256303
GMFBGALNT180.646796303

For details and further investigation, click here