| Full name: claudin 23 | Alias Symbol: CLDNL | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 137075 | HGNC ID: HGNC:17591 | Ensembl Gene: ENSG00000253958 | OMIM ID: 609203 |
| Drug and gene relationship at DGIdb | |||
CLDN23 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN23 | 137075 | 228707_at | 1.0633 | 0.2672 | |
| GSE26886 | CLDN23 | 137075 | 228707_at | -0.3677 | 0.3701 | |
| GSE45670 | CLDN23 | 137075 | 228707_at | -0.2185 | 0.4540 | |
| GSE53622 | CLDN23 | 137075 | 144435 | -0.5121 | 0.0113 | |
| GSE53624 | CLDN23 | 137075 | 144435 | -0.7816 | 0.0000 | |
| GSE63941 | CLDN23 | 137075 | 228707_at | -5.1796 | 0.0000 | |
| GSE77861 | CLDN23 | 137075 | 228707_at | 0.0307 | 0.9146 | |
| GSE97050 | CLDN23 | 137075 | A_23_P134854 | -0.1995 | 0.5444 | |
| SRP007169 | CLDN23 | 137075 | RNAseq | -1.8136 | 0.0197 | |
| SRP064894 | CLDN23 | 137075 | RNAseq | -0.0068 | 0.9781 | |
| SRP133303 | CLDN23 | 137075 | RNAseq | -0.5601 | 0.0156 | |
| SRP159526 | CLDN23 | 137075 | RNAseq | -0.4504 | 0.3919 | |
| SRP193095 | CLDN23 | 137075 | RNAseq | -0.9557 | 0.0376 | |
| SRP219564 | CLDN23 | 137075 | RNAseq | 0.2861 | 0.6041 | |
| TCGA | CLDN23 | 137075 | RNAseq | -0.9563 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CLDN23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN23 | 137075 | 4 | 10 | 16 | |
| GSE20123 | CLDN23 | 137075 | 4 | 10 | 16 | |
| GSE43470 | CLDN23 | 137075 | 4 | 9 | 30 | |
| GSE46452 | CLDN23 | 137075 | 12 | 14 | 33 | |
| GSE47630 | CLDN23 | 137075 | 10 | 7 | 23 | |
| GSE54993 | CLDN23 | 137075 | 3 | 14 | 53 | |
| GSE54994 | CLDN23 | 137075 | 9 | 18 | 26 | |
| GSE60625 | CLDN23 | 137075 | 3 | 0 | 8 | |
| GSE74703 | CLDN23 | 137075 | 4 | 7 | 25 | |
| GSE74704 | CLDN23 | 137075 | 3 | 7 | 10 | |
| TCGA | CLDN23 | 137075 | 13 | 40 | 43 |
Total number of gains: 69; Total number of losses: 136; Total Number of normals: 283.
Somatic mutations of CLDN23:
Generating mutation plots.
Highly correlated genes for CLDN23:
Showing top 20/22 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN23 | ATF6B | 0.678084 | 3 | 0 | 3 |
| CLDN23 | LIMD1 | 0.648821 | 3 | 0 | 3 |
| CLDN23 | RAD54L2 | 0.620715 | 3 | 0 | 3 |
| CLDN23 | TMEM87B | 0.608485 | 3 | 0 | 3 |
| CLDN23 | AMPD2 | 0.6083 | 3 | 0 | 3 |
| CLDN23 | OTUD4 | 0.604892 | 4 | 0 | 3 |
| CLDN23 | SLC35B4 | 0.586526 | 4 | 0 | 4 |
| CLDN23 | CLIC6 | 0.585189 | 5 | 0 | 4 |
| CLDN23 | TNIP2 | 0.584946 | 3 | 0 | 3 |
| CLDN23 | SLC22A16 | 0.567775 | 3 | 0 | 3 |
| CLDN23 | WNT2B | 0.562718 | 3 | 0 | 3 |
| CLDN23 | CYP2C8 | 0.561096 | 4 | 0 | 3 |
| CLDN23 | EDEM3 | 0.551702 | 5 | 0 | 4 |
| CLDN23 | DNAJC16 | 0.543841 | 5 | 0 | 3 |
| CLDN23 | TIGD7 | 0.541492 | 3 | 0 | 3 |
| CLDN23 | PLCL2 | 0.534808 | 5 | 0 | 3 |
| CLDN23 | TRAM1L1 | 0.534274 | 4 | 0 | 3 |
| CLDN23 | TP53INP1 | 0.532238 | 4 | 0 | 3 |
| CLDN23 | RIPK1 | 0.519953 | 4 | 0 | 3 |
| CLDN23 | SCP2 | 0.518 | 4 | 0 | 3 |
For details and further investigation, click here
