| Full name: acyl-CoA thioesterase 4 | Alias Symbol: FLJ31235|PTE-Ib|PTE2B | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 122970 | HGNC ID: HGNC:19748 | Ensembl Gene: ENSG00000177465 | OMIM ID: 614314 |
| Drug and gene relationship at DGIdb | |||
Expression of ACOT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACOT4 | 122970 | 229534_at | 0.0348 | 0.9678 | |
| GSE26886 | ACOT4 | 122970 | 229534_at | -0.2809 | 0.3060 | |
| GSE45670 | ACOT4 | 122970 | 229534_at | -0.8712 | 0.0003 | |
| GSE53622 | ACOT4 | 122970 | 20773 | -0.2479 | 0.1567 | |
| GSE53624 | ACOT4 | 122970 | 20773 | -0.8855 | 0.0000 | |
| GSE63941 | ACOT4 | 122970 | 229534_at | 1.4818 | 0.2153 | |
| GSE77861 | ACOT4 | 122970 | 229534_at | -0.4369 | 0.0818 | |
| GSE97050 | ACOT4 | 122970 | A_23_P14515 | -0.0076 | 0.9882 | |
| SRP007169 | ACOT4 | 122970 | RNAseq | -3.5464 | 0.0000 | |
| SRP008496 | ACOT4 | 122970 | RNAseq | -2.7819 | 0.0000 | |
| SRP064894 | ACOT4 | 122970 | RNAseq | -0.6534 | 0.0644 | |
| SRP133303 | ACOT4 | 122970 | RNAseq | -0.6740 | 0.0478 | |
| SRP159526 | ACOT4 | 122970 | RNAseq | -1.1665 | 0.0009 | |
| SRP193095 | ACOT4 | 122970 | RNAseq | -1.1574 | 0.0000 | |
| SRP219564 | ACOT4 | 122970 | RNAseq | -0.9337 | 0.1702 | |
| TCGA | ACOT4 | 122970 | RNAseq | 0.2532 | 0.1562 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ACOT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACOT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACOT4 | 122970 | 8 | 2 | 20 | |
| GSE20123 | ACOT4 | 122970 | 8 | 2 | 20 | |
| GSE43470 | ACOT4 | 122970 | 8 | 3 | 32 | |
| GSE46452 | ACOT4 | 122970 | 16 | 3 | 40 | |
| GSE47630 | ACOT4 | 122970 | 11 | 8 | 21 | |
| GSE54993 | ACOT4 | 122970 | 3 | 8 | 59 | |
| GSE54994 | ACOT4 | 122970 | 18 | 4 | 31 | |
| GSE60625 | ACOT4 | 122970 | 0 | 2 | 9 | |
| GSE74703 | ACOT4 | 122970 | 7 | 3 | 26 | |
| GSE74704 | ACOT4 | 122970 | 3 | 2 | 15 | |
| TCGA | ACOT4 | 122970 | 31 | 16 | 49 |
Total number of gains: 113; Total number of losses: 53; Total Number of normals: 322.
Somatic mutations of ACOT4:
Generating mutation plots.
Highly correlated genes for ACOT4:
Showing top 20/114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACOT4 | TSPAN1 | 0.659104 | 3 | 0 | 3 |
| ACOT4 | PADI3 | 0.64681 | 3 | 0 | 3 |
| ACOT4 | SLC29A3 | 0.643542 | 3 | 0 | 3 |
| ACOT4 | ALG14 | 0.641625 | 4 | 0 | 3 |
| ACOT4 | LRP11 | 0.62991 | 3 | 0 | 3 |
| ACOT4 | HECTD3 | 0.624543 | 4 | 0 | 3 |
| ACOT4 | STYK1 | 0.621936 | 3 | 0 | 3 |
| ACOT4 | EIF4E3 | 0.62171 | 3 | 0 | 3 |
| ACOT4 | LINC00852 | 0.619933 | 4 | 0 | 3 |
| ACOT4 | TSPAN14 | 0.618558 | 4 | 0 | 3 |
| ACOT4 | RAP1A | 0.617786 | 3 | 0 | 3 |
| ACOT4 | HLA-DQB2 | 0.614814 | 3 | 0 | 3 |
| ACOT4 | DVL1 | 0.613416 | 3 | 0 | 3 |
| ACOT4 | SLC25A10 | 0.613336 | 3 | 0 | 3 |
| ACOT4 | CTNNBIP1 | 0.603418 | 5 | 0 | 4 |
| ACOT4 | PWWP2B | 0.599832 | 5 | 0 | 5 |
| ACOT4 | MVB12A | 0.599125 | 4 | 0 | 3 |
| ACOT4 | MED25 | 0.585416 | 3 | 0 | 3 |
| ACOT4 | HOOK2 | 0.584877 | 4 | 0 | 3 |
| ACOT4 | SSU72 | 0.581654 | 3 | 0 | 3 |
For details and further investigation, click here
