| Full name: pleckstrin homology and RhoGEF domain containing G6 | Alias Symbol: FLJ10665|MYOGEF | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 55200 | HGNC ID: HGNC:25562 | Ensembl Gene: ENSG00000008323 | OMIM ID: 611743 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHG6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHG6 | 55200 | 220073_s_at | -0.5097 | 0.2202 | |
| GSE20347 | PLEKHG6 | 55200 | 220073_s_at | -1.2251 | 0.0000 | |
| GSE23400 | PLEKHG6 | 55200 | 220073_s_at | -0.7400 | 0.0000 | |
| GSE26886 | PLEKHG6 | 55200 | 220073_s_at | -0.2215 | 0.4685 | |
| GSE29001 | PLEKHG6 | 55200 | 220073_s_at | -0.7801 | 0.0000 | |
| GSE38129 | PLEKHG6 | 55200 | 220073_s_at | -0.8774 | 0.0002 | |
| GSE45670 | PLEKHG6 | 55200 | 220073_s_at | -0.5855 | 0.0137 | |
| GSE53622 | PLEKHG6 | 55200 | 29166 | -1.3125 | 0.0000 | |
| GSE53624 | PLEKHG6 | 55200 | 29166 | -1.5057 | 0.0000 | |
| GSE63941 | PLEKHG6 | 55200 | 220073_s_at | 1.0932 | 0.0109 | |
| GSE77861 | PLEKHG6 | 55200 | 220073_s_at | -0.2967 | 0.0944 | |
| GSE97050 | PLEKHG6 | 55200 | A_24_P301063 | -0.9683 | 0.0631 | |
| SRP007169 | PLEKHG6 | 55200 | RNAseq | -2.6979 | 0.0000 | |
| SRP008496 | PLEKHG6 | 55200 | RNAseq | -2.7151 | 0.0000 | |
| SRP064894 | PLEKHG6 | 55200 | RNAseq | -2.7846 | 0.0000 | |
| SRP133303 | PLEKHG6 | 55200 | RNAseq | -1.4335 | 0.0000 | |
| SRP159526 | PLEKHG6 | 55200 | RNAseq | -1.3693 | 0.0006 | |
| SRP193095 | PLEKHG6 | 55200 | RNAseq | -1.0486 | 0.0000 | |
| SRP219564 | PLEKHG6 | 55200 | RNAseq | -1.8075 | 0.0503 | |
| TCGA | PLEKHG6 | 55200 | RNAseq | 0.0646 | 0.7535 |
Upregulated datasets: 1; Downregulated datasets: 9.
Survival by PLEKHG6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHG6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHG6 | 55200 | 9 | 3 | 18 | |
| GSE20123 | PLEKHG6 | 55200 | 9 | 3 | 18 | |
| GSE43470 | PLEKHG6 | 55200 | 8 | 3 | 32 | |
| GSE46452 | PLEKHG6 | 55200 | 10 | 1 | 48 | |
| GSE47630 | PLEKHG6 | 55200 | 12 | 2 | 26 | |
| GSE54993 | PLEKHG6 | 55200 | 1 | 10 | 59 | |
| GSE54994 | PLEKHG6 | 55200 | 10 | 2 | 41 | |
| GSE60625 | PLEKHG6 | 55200 | 0 | 1 | 10 | |
| GSE74703 | PLEKHG6 | 55200 | 7 | 2 | 27 | |
| GSE74704 | PLEKHG6 | 55200 | 5 | 2 | 13 | |
| TCGA | PLEKHG6 | 55200 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.
Somatic mutations of PLEKHG6:
Generating mutation plots.
Highly correlated genes for PLEKHG6:
Showing top 20/1248 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHG6 | ANO8 | 0.786873 | 4 | 0 | 4 |
| PLEKHG6 | GYS2 | 0.786754 | 9 | 0 | 9 |
| PLEKHG6 | PADI1 | 0.776013 | 8 | 0 | 8 |
| PLEKHG6 | TOM1 | 0.769593 | 10 | 0 | 10 |
| PLEKHG6 | TTC9 | 0.765402 | 10 | 0 | 10 |
| PLEKHG6 | EVPL | 0.764122 | 11 | 0 | 10 |
| PLEKHG6 | NLRX1 | 0.762172 | 9 | 0 | 9 |
| PLEKHG6 | FUT3 | 0.761619 | 9 | 0 | 9 |
| PLEKHG6 | GDPD3 | 0.761049 | 9 | 0 | 9 |
| PLEKHG6 | RECQL5 | 0.755228 | 11 | 0 | 11 |
| PLEKHG6 | PLEKHM1 | 0.750251 | 11 | 0 | 10 |
| PLEKHG6 | SCNN1B | 0.749395 | 10 | 0 | 9 |
| PLEKHG6 | DDI2 | 0.743109 | 3 | 0 | 3 |
| PLEKHG6 | IL36A | 0.740596 | 9 | 0 | 8 |
| PLEKHG6 | PSCA | 0.740412 | 7 | 0 | 7 |
| PLEKHG6 | EPS8L1 | 0.73959 | 10 | 0 | 9 |
| PLEKHG6 | SH3GL1 | 0.737397 | 10 | 0 | 9 |
| PLEKHG6 | PPL | 0.737297 | 10 | 0 | 10 |
| PLEKHG6 | SFTA2 | 0.73627 | 3 | 0 | 3 |
| PLEKHG6 | ARHGAP27 | 0.735934 | 7 | 0 | 7 |
For details and further investigation, click here
