| Full name: glutathione peroxidase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q33.1 | ||
| Entrez ID: 2878 | HGNC ID: HGNC:4555 | Ensembl Gene: ENSG00000211445 | OMIM ID: 138321 |
| Drug and gene relationship at DGIdb | |||
Expression of GPX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPX3 | 2878 | 201348_at | -2.4602 | 0.0250 | |
| GSE20347 | GPX3 | 2878 | 201348_at | -3.4944 | 0.0000 | |
| GSE23400 | GPX3 | 2878 | 201348_at | -2.4989 | 0.0000 | |
| GSE26886 | GPX3 | 2878 | 201348_at | -5.5567 | 0.0000 | |
| GSE29001 | GPX3 | 2878 | 201348_at | -3.7645 | 0.0000 | |
| GSE38129 | GPX3 | 2878 | 201348_at | -3.2805 | 0.0000 | |
| GSE45670 | GPX3 | 2878 | 201348_at | -1.4395 | 0.0283 | |
| GSE53622 | GPX3 | 2878 | 33129 | -2.1716 | 0.0000 | |
| GSE53624 | GPX3 | 2878 | 33129 | -1.7845 | 0.0000 | |
| GSE63941 | GPX3 | 2878 | 201348_at | -2.4364 | 0.3540 | |
| GSE77861 | GPX3 | 2878 | 201348_at | -1.8859 | 0.0936 | |
| GSE97050 | GPX3 | 2878 | A_23_P133474 | -0.9017 | 0.0875 | |
| SRP007169 | GPX3 | 2878 | RNAseq | -4.6745 | 0.0000 | |
| SRP008496 | GPX3 | 2878 | RNAseq | -3.3652 | 0.0000 | |
| SRP064894 | GPX3 | 2878 | RNAseq | -2.1147 | 0.0000 | |
| SRP133303 | GPX3 | 2878 | RNAseq | -1.9845 | 0.0000 | |
| SRP159526 | GPX3 | 2878 | RNAseq | -2.8707 | 0.0000 | |
| SRP193095 | GPX3 | 2878 | RNAseq | -2.5157 | 0.0000 | |
| SRP219564 | GPX3 | 2878 | RNAseq | -1.5830 | 0.0015 | |
| TCGA | GPX3 | 2878 | RNAseq | -0.6044 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by GPX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPX3 | 2878 | 1 | 12 | 17 | |
| GSE20123 | GPX3 | 2878 | 1 | 12 | 17 | |
| GSE43470 | GPX3 | 2878 | 1 | 10 | 32 | |
| GSE46452 | GPX3 | 2878 | 0 | 27 | 32 | |
| GSE47630 | GPX3 | 2878 | 0 | 20 | 20 | |
| GSE54993 | GPX3 | 2878 | 9 | 1 | 60 | |
| GSE54994 | GPX3 | 2878 | 2 | 15 | 36 | |
| GSE60625 | GPX3 | 2878 | 0 | 0 | 11 | |
| GSE74703 | GPX3 | 2878 | 1 | 7 | 28 | |
| GSE74704 | GPX3 | 2878 | 1 | 7 | 12 | |
| TCGA | GPX3 | 2878 | 5 | 37 | 54 |
Total number of gains: 21; Total number of losses: 148; Total Number of normals: 319.
Somatic mutations of GPX3:
Generating mutation plots.
Highly correlated genes for GPX3:
Showing top 20/1793 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPX3 | VSIG10L | 0.840764 | 6 | 0 | 6 |
| GPX3 | MGLL | 0.821358 | 11 | 0 | 11 |
| GPX3 | ENDOU | 0.809025 | 11 | 0 | 11 |
| GPX3 | CYSRT1 | 0.806701 | 6 | 0 | 6 |
| GPX3 | MXD1 | 0.803747 | 10 | 0 | 10 |
| GPX3 | FCHO2 | 0.802267 | 7 | 0 | 7 |
| GPX3 | CRISP3 | 0.802239 | 11 | 0 | 11 |
| GPX3 | S100A14 | 0.80172 | 9 | 0 | 9 |
| GPX3 | KAT2B | 0.801262 | 11 | 0 | 11 |
| GPX3 | CA13 | 0.798335 | 3 | 0 | 3 |
| GPX3 | RMND5B | 0.794889 | 11 | 0 | 11 |
| GPX3 | SCNN1B | 0.79433 | 10 | 0 | 10 |
| GPX3 | SASH1 | 0.790797 | 11 | 0 | 11 |
| GPX3 | SMIM5 | 0.790768 | 6 | 0 | 6 |
| GPX3 | TRIP10 | 0.789516 | 11 | 0 | 11 |
| GPX3 | SH3BGRL2 | 0.787961 | 7 | 0 | 7 |
| GPX3 | TMPRSS11E | 0.786431 | 10 | 0 | 10 |
| GPX3 | CASC3 | 0.786341 | 3 | 0 | 3 |
| GPX3 | LRP10 | 0.785426 | 11 | 0 | 11 |
| GPX3 | FMO2 | 0.785244 | 11 | 0 | 11 |
For details and further investigation, click here
