| Full name: peptidyl arginine deiminase 4 | Alias Symbol: PAD|PDI5|PDI4 | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 23569 | HGNC ID: HGNC:18368 | Ensembl Gene: ENSG00000159339 | OMIM ID: 605347 |
| Drug and gene relationship at DGIdb | |||
Expression of PADI4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PADI4 | 23569 | 220001_at | 0.0951 | 0.7657 | |
| GSE20347 | PADI4 | 23569 | 211413_s_at | -0.1724 | 0.0042 | |
| GSE23400 | PADI4 | 23569 | 220001_at | -0.0244 | 0.2881 | |
| GSE26886 | PADI4 | 23569 | 211413_s_at | 0.1462 | 0.2547 | |
| GSE29001 | PADI4 | 23569 | 220001_at | -0.0592 | 0.6435 | |
| GSE38129 | PADI4 | 23569 | 211413_s_at | -0.1277 | 0.0094 | |
| GSE45670 | PADI4 | 23569 | 211413_s_at | 0.0039 | 0.9678 | |
| GSE53622 | PADI4 | 23569 | 72802 | -0.7105 | 0.0053 | |
| GSE53624 | PADI4 | 23569 | 72802 | -0.2993 | 0.2067 | |
| GSE63941 | PADI4 | 23569 | 211413_s_at | 0.0253 | 0.8841 | |
| GSE77861 | PADI4 | 23569 | 211413_s_at | -0.2067 | 0.0832 | |
| TCGA | PADI4 | 23569 | RNAseq | -0.9197 | 0.1985 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PADI4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PADI4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PADI4 | 23569 | 0 | 5 | 25 | |
| GSE20123 | PADI4 | 23569 | 0 | 4 | 26 | |
| GSE43470 | PADI4 | 23569 | 0 | 8 | 35 | |
| GSE46452 | PADI4 | 23569 | 5 | 1 | 53 | |
| GSE47630 | PADI4 | 23569 | 8 | 3 | 29 | |
| GSE54993 | PADI4 | 23569 | 3 | 1 | 66 | |
| GSE54994 | PADI4 | 23569 | 10 | 4 | 39 | |
| GSE60625 | PADI4 | 23569 | 0 | 0 | 11 | |
| GSE74703 | PADI4 | 23569 | 0 | 5 | 31 | |
| GSE74704 | PADI4 | 23569 | 0 | 0 | 20 | |
| TCGA | PADI4 | 23569 | 10 | 22 | 64 |
Total number of gains: 36; Total number of losses: 53; Total Number of normals: 399.
Somatic mutations of PADI4:
Generating mutation plots.
Highly correlated genes for PADI4:
Showing top 20/139 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PADI4 | SIGLEC5 | 0.734561 | 3 | 0 | 3 |
| PADI4 | PROK2 | 0.71728 | 3 | 0 | 3 |
| PADI4 | GIMAP1 | 0.679124 | 3 | 0 | 3 |
| PADI4 | CMTM2 | 0.668973 | 4 | 0 | 3 |
| PADI4 | MILR1 | 0.664169 | 3 | 0 | 3 |
| PADI4 | RBP4 | 0.662759 | 3 | 0 | 3 |
| PADI4 | SELL | 0.661594 | 3 | 0 | 3 |
| PADI4 | DOCK2 | 0.632046 | 3 | 0 | 3 |
| PADI4 | NAGK | 0.63165 | 3 | 0 | 3 |
| PADI4 | PPP1R17 | 0.630426 | 3 | 0 | 3 |
| PADI4 | DIO1 | 0.627978 | 3 | 0 | 3 |
| PADI4 | KCNG2 | 0.624635 | 3 | 0 | 3 |
| PADI4 | RGS18 | 0.621683 | 4 | 0 | 3 |
| PADI4 | ALOX5AP | 0.619454 | 4 | 0 | 3 |
| PADI4 | CSMD1 | 0.615443 | 3 | 0 | 3 |
| PADI4 | MRPS18C | 0.610761 | 4 | 0 | 3 |
| PADI4 | RAB11A | 0.607358 | 3 | 0 | 3 |
| PADI4 | TLR8 | 0.605506 | 5 | 0 | 4 |
| PADI4 | PDYN | 0.603648 | 4 | 0 | 3 |
| PADI4 | SLC9A7 | 0.60178 | 3 | 0 | 3 |
For details and further investigation, click here
