| Full name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | Alias Symbol: ATPSK1|PAPSS | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 9061 | HGNC ID: HGNC:8603 | Ensembl Gene: ENSG00000138801 | OMIM ID: 603262 |
| Drug and gene relationship at DGIdb | |||
Expression of PAPSS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAPSS1 | 9061 | 209043_at | -0.0323 | 0.9484 | |
| GSE20347 | PAPSS1 | 9061 | 209043_at | -0.3791 | 0.0369 | |
| GSE23400 | PAPSS1 | 9061 | 209043_at | -0.0923 | 0.2220 | |
| GSE26886 | PAPSS1 | 9061 | 209043_at | -1.1118 | 0.0000 | |
| GSE29001 | PAPSS1 | 9061 | 209043_at | -0.3029 | 0.3868 | |
| GSE38129 | PAPSS1 | 9061 | 209043_at | -0.2255 | 0.2271 | |
| GSE45670 | PAPSS1 | 9061 | 209043_at | -0.2928 | 0.0696 | |
| GSE53622 | PAPSS1 | 9061 | 22622 | -0.0953 | 0.2242 | |
| GSE53624 | PAPSS1 | 9061 | 22622 | -0.3445 | 0.0000 | |
| GSE63941 | PAPSS1 | 9061 | 209043_at | -0.5685 | 0.1830 | |
| GSE77861 | PAPSS1 | 9061 | 209043_at | -0.3704 | 0.2569 | |
| GSE97050 | PAPSS1 | 9061 | A_23_P144465 | 0.1195 | 0.7221 | |
| SRP007169 | PAPSS1 | 9061 | RNAseq | -0.6261 | 0.0617 | |
| SRP008496 | PAPSS1 | 9061 | RNAseq | -0.3858 | 0.0444 | |
| SRP064894 | PAPSS1 | 9061 | RNAseq | -0.0669 | 0.6985 | |
| SRP133303 | PAPSS1 | 9061 | RNAseq | -0.0096 | 0.9532 | |
| SRP159526 | PAPSS1 | 9061 | RNAseq | -0.0681 | 0.8122 | |
| SRP193095 | PAPSS1 | 9061 | RNAseq | -0.5913 | 0.0000 | |
| SRP219564 | PAPSS1 | 9061 | RNAseq | -0.2482 | 0.3011 | |
| TCGA | PAPSS1 | 9061 | RNAseq | -0.1402 | 0.0058 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PAPSS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAPSS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAPSS1 | 9061 | 0 | 12 | 18 | |
| GSE20123 | PAPSS1 | 9061 | 0 | 12 | 18 | |
| GSE43470 | PAPSS1 | 9061 | 0 | 13 | 30 | |
| GSE46452 | PAPSS1 | 9061 | 1 | 36 | 22 | |
| GSE47630 | PAPSS1 | 9061 | 0 | 20 | 20 | |
| GSE54993 | PAPSS1 | 9061 | 9 | 0 | 61 | |
| GSE54994 | PAPSS1 | 9061 | 1 | 10 | 42 | |
| GSE60625 | PAPSS1 | 9061 | 0 | 3 | 8 | |
| GSE74703 | PAPSS1 | 9061 | 0 | 11 | 25 | |
| GSE74704 | PAPSS1 | 9061 | 0 | 6 | 14 | |
| TCGA | PAPSS1 | 9061 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 158; Total Number of normals: 311.
Somatic mutations of PAPSS1:
Generating mutation plots.
Highly correlated genes for PAPSS1:
Showing top 20/463 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAPSS1 | STK38 | 0.762017 | 3 | 0 | 3 |
| PAPSS1 | MCU | 0.751774 | 3 | 0 | 3 |
| PAPSS1 | DNAJB6 | 0.743223 | 3 | 0 | 3 |
| PAPSS1 | AP3M1 | 0.741553 | 3 | 0 | 3 |
| PAPSS1 | ZNF416 | 0.710085 | 3 | 0 | 3 |
| PAPSS1 | RBBP4 | 0.704197 | 3 | 0 | 3 |
| PAPSS1 | VSIG10L | 0.694187 | 3 | 0 | 3 |
| PAPSS1 | VGLL4 | 0.691834 | 3 | 0 | 3 |
| PAPSS1 | COBLL1 | 0.67279 | 3 | 0 | 3 |
| PAPSS1 | SIAE | 0.659039 | 6 | 0 | 5 |
| PAPSS1 | PITRM1 | 0.658739 | 3 | 0 | 3 |
| PAPSS1 | NDUFV2 | 0.658381 | 3 | 0 | 3 |
| PAPSS1 | BLOC1S2 | 0.65836 | 4 | 0 | 4 |
| PAPSS1 | NCOA4 | 0.656978 | 4 | 0 | 3 |
| PAPSS1 | UBE2D2 | 0.655607 | 3 | 0 | 3 |
| PAPSS1 | FBXO8 | 0.649032 | 4 | 0 | 4 |
| PAPSS1 | ZNF493 | 0.647392 | 3 | 0 | 3 |
| PAPSS1 | GBP6 | 0.646652 | 3 | 0 | 3 |
| PAPSS1 | FAM174A | 0.646297 | 3 | 0 | 3 |
| PAPSS1 | SCAMP2 | 0.646067 | 4 | 0 | 3 |
For details and further investigation, click here
