| Full name: lysophosphatidylcholine acyltransferase 3 | Alias Symbol: C3F|nessy | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 10162 | HGNC ID: HGNC:30244 | Ensembl Gene: ENSG00000111684 | OMIM ID: 611950 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LPCAT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LPCAT3 | 10162 | 202793_at | 0.3762 | 0.6264 | |
| GSE20347 | LPCAT3 | 10162 | 202793_at | 0.1583 | 0.2402 | |
| GSE23400 | LPCAT3 | 10162 | 213615_at | -0.1844 | 0.0021 | |
| GSE26886 | LPCAT3 | 10162 | 213615_at | 0.5763 | 0.0237 | |
| GSE29001 | LPCAT3 | 10162 | 213615_at | 0.2933 | 0.1045 | |
| GSE38129 | LPCAT3 | 10162 | 202793_at | 0.1870 | 0.1090 | |
| GSE45670 | LPCAT3 | 10162 | 202793_at | 0.2933 | 0.0715 | |
| GSE53622 | LPCAT3 | 10162 | 81895 | 0.6292 | 0.0000 | |
| GSE53624 | LPCAT3 | 10162 | 81895 | 0.5148 | 0.0000 | |
| GSE63941 | LPCAT3 | 10162 | 202793_at | 0.4328 | 0.4538 | |
| GSE77861 | LPCAT3 | 10162 | 202793_at | -0.0349 | 0.8586 | |
| GSE97050 | LPCAT3 | 10162 | A_33_P3295283 | 0.1965 | 0.5355 | |
| SRP007169 | LPCAT3 | 10162 | RNAseq | 0.5284 | 0.2126 | |
| SRP008496 | LPCAT3 | 10162 | RNAseq | 0.5831 | 0.0263 | |
| SRP064894 | LPCAT3 | 10162 | RNAseq | 0.2112 | 0.2772 | |
| SRP133303 | LPCAT3 | 10162 | RNAseq | 0.6043 | 0.0201 | |
| SRP159526 | LPCAT3 | 10162 | RNAseq | 0.1691 | 0.5974 | |
| SRP193095 | LPCAT3 | 10162 | RNAseq | -0.0130 | 0.9442 | |
| SRP219564 | LPCAT3 | 10162 | RNAseq | 0.0739 | 0.7843 | |
| TCGA | LPCAT3 | 10162 | RNAseq | -0.0327 | 0.5760 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LPCAT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LPCAT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LPCAT3 | 10162 | 9 | 3 | 18 | |
| GSE20123 | LPCAT3 | 10162 | 9 | 3 | 18 | |
| GSE43470 | LPCAT3 | 10162 | 8 | 3 | 32 | |
| GSE46452 | LPCAT3 | 10162 | 10 | 1 | 48 | |
| GSE47630 | LPCAT3 | 10162 | 12 | 2 | 26 | |
| GSE54993 | LPCAT3 | 10162 | 1 | 10 | 59 | |
| GSE54994 | LPCAT3 | 10162 | 10 | 2 | 41 | |
| GSE60625 | LPCAT3 | 10162 | 0 | 1 | 10 | |
| GSE74703 | LPCAT3 | 10162 | 7 | 2 | 27 | |
| GSE74704 | LPCAT3 | 10162 | 5 | 3 | 12 | |
| TCGA | LPCAT3 | 10162 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.
Somatic mutations of LPCAT3:
Generating mutation plots.
Highly correlated genes for LPCAT3:
Showing top 20/488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LPCAT3 | PARG | 0.832366 | 3 | 0 | 3 |
| LPCAT3 | CLEC16A | 0.815541 | 3 | 0 | 3 |
| LPCAT3 | WDR77 | 0.807208 | 3 | 0 | 3 |
| LPCAT3 | TAF10 | 0.800871 | 3 | 0 | 3 |
| LPCAT3 | PLEKHA2 | 0.778545 | 3 | 0 | 3 |
| LPCAT3 | PDCD6 | 0.769418 | 3 | 0 | 3 |
| LPCAT3 | IFT80 | 0.728158 | 3 | 0 | 3 |
| LPCAT3 | GSTCD | 0.724222 | 3 | 0 | 3 |
| LPCAT3 | SMU1 | 0.710473 | 3 | 0 | 3 |
| LPCAT3 | ZNF207 | 0.707903 | 3 | 0 | 3 |
| LPCAT3 | SMAD1 | 0.69437 | 3 | 0 | 3 |
| LPCAT3 | LRRK1 | 0.692287 | 3 | 0 | 3 |
| LPCAT3 | NIF3L1 | 0.688548 | 4 | 0 | 3 |
| LPCAT3 | ARHGEF18 | 0.687853 | 3 | 0 | 3 |
| LPCAT3 | TRAF7 | 0.687365 | 4 | 0 | 3 |
| LPCAT3 | HRH1 | 0.686885 | 3 | 0 | 3 |
| LPCAT3 | MRPL51 | 0.680892 | 9 | 0 | 7 |
| LPCAT3 | ARMC10 | 0.677538 | 5 | 0 | 5 |
| LPCAT3 | ALG10 | 0.673202 | 7 | 0 | 6 |
| LPCAT3 | DUSP18 | 0.672159 | 3 | 0 | 3 |
For details and further investigation, click here
