| Full name: origin recognition complex subunit 1 | Alias Symbol: HSORC1|PARC1 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 4998 | HGNC ID: HGNC:8487 | Ensembl Gene: ENSG00000085840 | OMIM ID: 601902 |
Screen Evidence:
| |||
ORC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of ORC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORC1 | 4998 | 205085_at | 0.9190 | 0.1909 | |
| GSE20347 | ORC1 | 4998 | 205085_at | 0.5031 | 0.0029 | |
| GSE23400 | ORC1 | 4998 | 205085_at | 0.1895 | 0.0000 | |
| GSE26886 | ORC1 | 4998 | 205085_at | 0.5305 | 0.0113 | |
| GSE29001 | ORC1 | 4998 | 205085_at | 0.2085 | 0.0556 | |
| GSE38129 | ORC1 | 4998 | 205085_at | 0.7614 | 0.0000 | |
| GSE45670 | ORC1 | 4998 | 205085_at | 0.6958 | 0.0015 | |
| GSE53622 | ORC1 | 4998 | 113979 | 0.9726 | 0.0000 | |
| GSE53624 | ORC1 | 4998 | 113979 | 1.3582 | 0.0000 | |
| GSE63941 | ORC1 | 4998 | 205085_at | 2.5699 | 0.0009 | |
| GSE77861 | ORC1 | 4998 | 205085_at | 0.1028 | 0.5572 | |
| GSE97050 | ORC1 | 4998 | A_23_P45799 | 0.2393 | 0.2757 | |
| SRP007169 | ORC1 | 4998 | RNAseq | 3.8708 | 0.0000 | |
| SRP064894 | ORC1 | 4998 | RNAseq | 1.2458 | 0.0000 | |
| SRP133303 | ORC1 | 4998 | RNAseq | 1.3542 | 0.0000 | |
| SRP159526 | ORC1 | 4998 | RNAseq | 1.4775 | 0.0030 | |
| SRP193095 | ORC1 | 4998 | RNAseq | 1.0385 | 0.0000 | |
| SRP219564 | ORC1 | 4998 | RNAseq | 2.1185 | 0.0027 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by ORC1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ORC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORC1 | 4998 | 3 | 4 | 23 | |
| GSE20123 | ORC1 | 4998 | 3 | 3 | 24 | |
| GSE43470 | ORC1 | 4998 | 5 | 2 | 36 | |
| GSE46452 | ORC1 | 4998 | 2 | 1 | 56 | |
| GSE47630 | ORC1 | 4998 | 8 | 4 | 28 | |
| GSE54993 | ORC1 | 4998 | 0 | 1 | 69 | |
| GSE54994 | ORC1 | 4998 | 11 | 2 | 40 | |
| GSE60625 | ORC1 | 4998 | 0 | 0 | 11 | |
| GSE74703 | ORC1 | 4998 | 4 | 1 | 31 | |
| GSE74704 | ORC1 | 4998 | 2 | 0 | 18 | |
| TCGA | ORC1 | 4998 | 10 | 18 | 68 |
Total number of gains: 48; Total number of losses: 36; Total Number of normals: 404.
Somatic mutations of ORC1:
Generating mutation plots.
Highly correlated genes for ORC1:
Showing top 20/1670 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORC1 | RAD18 | 0.778864 | 3 | 0 | 3 |
| ORC1 | KTI12 | 0.759326 | 3 | 0 | 3 |
| ORC1 | CDCA8 | 0.758369 | 11 | 0 | 10 |
| ORC1 | SASS6 | 0.753351 | 6 | 0 | 6 |
| ORC1 | NDC1 | 0.748857 | 10 | 0 | 10 |
| ORC1 | MTHFD1L | 0.747667 | 3 | 0 | 3 |
| ORC1 | EBNA1BP2 | 0.744804 | 3 | 0 | 3 |
| ORC1 | SAMD1 | 0.739716 | 4 | 0 | 4 |
| ORC1 | IQGAP3 | 0.73234 | 5 | 0 | 5 |
| ORC1 | WDHD1 | 0.729915 | 12 | 0 | 11 |
| ORC1 | CDT1 | 0.729444 | 12 | 0 | 11 |
| ORC1 | RAD51AP1 | 0.726848 | 10 | 0 | 10 |
| ORC1 | TRAF7 | 0.726338 | 4 | 0 | 4 |
| ORC1 | RFC2 | 0.725218 | 12 | 0 | 11 |
| ORC1 | CKAP2L | 0.721237 | 7 | 0 | 6 |
| ORC1 | ZDHHC16 | 0.719947 | 5 | 0 | 5 |
| ORC1 | NCAPH | 0.718794 | 9 | 0 | 9 |
| ORC1 | SPAG5 | 0.718275 | 11 | 0 | 10 |
| ORC1 | ZNF689 | 0.71773 | 3 | 0 | 3 |
| ORC1 | ESCO2 | 0.71759 | 7 | 0 | 6 |
For details and further investigation, click here
