| Full name: PAX interacting protein 1 | Alias Symbol: CAGF29|CAGF28|TNRC2|PTIP | ||
| Type: protein-coding gene | Cytoband: 7q36.2 | ||
| Entrez ID: 22976 | HGNC ID: HGNC:8624 | Ensembl Gene: ENSG00000157212 | OMIM ID: 608254 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PAXIP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAXIP1 | 22976 | 212825_at | 0.3276 | 0.5581 | |
| GSE20347 | PAXIP1 | 22976 | 212825_at | 0.4096 | 0.0074 | |
| GSE23400 | PAXIP1 | 22976 | 212825_at | 0.5687 | 0.0000 | |
| GSE26886 | PAXIP1 | 22976 | 212825_at | 0.0316 | 0.9324 | |
| GSE29001 | PAXIP1 | 22976 | 212825_at | 0.4485 | 0.1512 | |
| GSE38129 | PAXIP1 | 22976 | 212825_at | 0.5455 | 0.0000 | |
| GSE45670 | PAXIP1 | 22976 | 212825_at | 0.1693 | 0.3553 | |
| GSE53622 | PAXIP1 | 22976 | 47265 | 0.1308 | 0.0555 | |
| GSE53624 | PAXIP1 | 22976 | 47265 | 0.2782 | 0.0001 | |
| GSE63941 | PAXIP1 | 22976 | 212825_at | 0.8392 | 0.0067 | |
| GSE77861 | PAXIP1 | 22976 | 212825_at | 0.3016 | 0.3669 | |
| GSE97050 | PAXIP1 | 22976 | A_23_P59426 | -0.1752 | 0.5912 | |
| SRP007169 | PAXIP1 | 22976 | RNAseq | 2.0564 | 0.0003 | |
| SRP064894 | PAXIP1 | 22976 | RNAseq | 0.3190 | 0.1255 | |
| SRP133303 | PAXIP1 | 22976 | RNAseq | 0.3489 | 0.0494 | |
| SRP159526 | PAXIP1 | 22976 | RNAseq | 0.0656 | 0.8357 | |
| SRP193095 | PAXIP1 | 22976 | RNAseq | 0.2301 | 0.0252 | |
| SRP219564 | PAXIP1 | 22976 | RNAseq | -0.0294 | 0.9267 | |
| TCGA | PAXIP1 | 22976 | RNAseq | 0.1201 | 0.0586 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PAXIP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAXIP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAXIP1 | 22976 | 3 | 3 | 24 | |
| GSE20123 | PAXIP1 | 22976 | 2 | 3 | 25 | |
| GSE43470 | PAXIP1 | 22976 | 2 | 5 | 36 | |
| GSE46452 | PAXIP1 | 22976 | 7 | 2 | 50 | |
| GSE47630 | PAXIP1 | 22976 | 6 | 9 | 25 | |
| GSE54993 | PAXIP1 | 22976 | 3 | 3 | 64 | |
| GSE54994 | PAXIP1 | 22976 | 6 | 8 | 39 | |
| GSE60625 | PAXIP1 | 22976 | 0 | 0 | 11 | |
| GSE74703 | PAXIP1 | 22976 | 2 | 4 | 30 | |
| GSE74704 | PAXIP1 | 22976 | 0 | 3 | 17 | |
| TCGA | PAXIP1 | 22976 | 27 | 26 | 43 |
Total number of gains: 58; Total number of losses: 66; Total Number of normals: 364.
Somatic mutations of PAXIP1:
Generating mutation plots.
Highly correlated genes for PAXIP1:
Showing top 20/408 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAXIP1 | ZNF850 | 0.757769 | 3 | 0 | 3 |
| PAXIP1 | KRT18 | 0.675913 | 3 | 0 | 3 |
| PAXIP1 | CSTF3 | 0.671209 | 5 | 0 | 5 |
| PAXIP1 | RHNO1 | 0.65537 | 4 | 0 | 4 |
| PAXIP1 | ZNF558 | 0.655271 | 3 | 0 | 3 |
| PAXIP1 | GDE1 | 0.648907 | 3 | 0 | 3 |
| PAXIP1 | AKT1S1 | 0.644516 | 3 | 0 | 3 |
| PAXIP1 | TOPBP1 | 0.644249 | 8 | 0 | 8 |
| PAXIP1 | RHEB | 0.643501 | 11 | 0 | 10 |
| PAXIP1 | PRPF38A | 0.642917 | 3 | 0 | 3 |
| PAXIP1 | KIAA1671 | 0.642766 | 3 | 0 | 3 |
| PAXIP1 | CUL1 | 0.633191 | 12 | 0 | 10 |
| PAXIP1 | PIK3R4 | 0.630058 | 8 | 0 | 7 |
| PAXIP1 | MRPL38 | 0.628881 | 4 | 0 | 3 |
| PAXIP1 | COPE | 0.626156 | 3 | 0 | 3 |
| PAXIP1 | UMPS | 0.623908 | 7 | 0 | 6 |
| PAXIP1 | LUC7L2 | 0.623398 | 7 | 0 | 6 |
| PAXIP1 | NUP160 | 0.623394 | 7 | 0 | 6 |
| PAXIP1 | RRM1 | 0.622556 | 6 | 0 | 6 |
| PAXIP1 | ERGIC2 | 0.620791 | 5 | 0 | 4 |
For details and further investigation, click here
