TOPBP1

 

Full name: DNA topoisomerase II binding protein 1 Alias Symbol: KIAA0259|TOP2BP1|Dpb11
Type: protein-coding gene Cytoband: 3q22.1
Entrez ID: 11073 HGNC ID: HGNC:17008 Ensembl Gene: ENSG00000163781 OMIM ID: 607760
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TOPBP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TOPBP1 11073 202633_at 0.9484 0.0523
GSE20347 TOPBP1 11073 202633_at 1.2030 0.0000
GSE23400 TOPBP1 11073 202633_at 1.2242 0.0000
GSE26886 TOPBP1 11073 202633_at 0.8791 0.0005
GSE29001 TOPBP1 11073 202633_at 1.3006 0.0014
GSE38129 TOPBP1 11073 202633_at 1.2725 0.0000
GSE45670 TOPBP1 11073 202633_at 0.6694 0.0035
GSE53622 TOPBP1 11073 4687 1.0521 0.0000
GSE53624 TOPBP1 11073 4687 1.1173 0.0000
GSE63941 TOPBP1 11073 202633_at 1.3497 0.0021
GSE77861 TOPBP1 11073 202633_at 0.9027 0.0286
GSE97050 TOPBP1 11073 A_23_P159390 1.0249 0.0796
SRP007169 TOPBP1 11073 RNAseq 2.2344 0.0000
SRP008496 TOPBP1 11073 RNAseq 2.3530 0.0000
SRP064894 TOPBP1 11073 RNAseq 0.7360 0.0034
SRP133303 TOPBP1 11073 RNAseq 0.9222 0.0000
SRP159526 TOPBP1 11073 RNAseq 1.2274 0.0009
SRP193095 TOPBP1 11073 RNAseq 0.8250 0.0000
SRP219564 TOPBP1 11073 RNAseq 0.6221 0.1134
TCGA TOPBP1 11073 RNAseq 0.3523 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by TOPBP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TOPBP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TOPBP1 11073 16 0 14
GSE20123 TOPBP1 11073 16 0 14
GSE43470 TOPBP1 11073 21 0 22
GSE46452 TOPBP1 11073 15 4 40
GSE47630 TOPBP1 11073 18 3 19
GSE54993 TOPBP1 11073 2 8 60
GSE54994 TOPBP1 11073 32 1 20
GSE60625 TOPBP1 11073 0 6 5
GSE74703 TOPBP1 11073 18 0 18
GSE74704 TOPBP1 11073 11 0 9
TCGA TOPBP1 11073 59 5 32

Total number of gains: 208; Total number of losses: 27; Total Number of normals: 253.  

 

Somatic mutations of TOPBP1:

 

Generating mutation plots.

 

Highly correlated genes for TOPBP1:

 

Showing top 20/2064 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TOPBP1AP3D10.832226303
TOPBP1ATR0.816412011
TOPBP1ATP2C10.81193312012
TOPBP1U2SURP0.81154310010
TOPBP1GMPS0.80515612012
TOPBP1ECT20.80053612012
TOPBP1MCM20.79839612012
TOPBP1TIMELESS0.79191112012
TOPBP1ACTL6A0.78869213012
TOPBP1HPS30.786361505
TOPBP1UMPS0.78465911011
TOPBP1RACGAP10.78108810010
TOPBP1PIK3R40.78080712011
TOPBP1RFC40.78041313013
TOPBP1UCK20.779931303
TOPBP1MMS22L0.777354303
TOPBP1GTF2E10.77222810010
TOPBP1RUVBL10.76721712012
TOPBP1ATAD20.76701412011
TOPBP1CDC42SE20.765244303

For details and further investigation, click here