| Full name: prostate cancer associated 3 | Alias Symbol: DD3|NCRNA00019|PCAT3|PRUNE2-AS1 | ||
| Type: non-coding RNA | Cytoband: 9q21.2 | ||
| Entrez ID: 50652 | HGNC ID: HGNC:8637 | Ensembl Gene: ENSG00000225937 | OMIM ID: 604845 |
| Drug and gene relationship at DGIdb | |||
Expression of PCA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCA3 | 50652 | 232572_at | -0.2115 | 0.2760 | |
| GSE26886 | PCA3 | 50652 | 232572_at | -0.2454 | 0.0129 | |
| GSE45670 | PCA3 | 50652 | 232572_at | 0.0267 | 0.7923 | |
| GSE53622 | PCA3 | 50652 | 69180 | 0.1248 | 0.1715 | |
| GSE53624 | PCA3 | 50652 | 69180 | -0.0461 | 0.6522 | |
| GSE63941 | PCA3 | 50652 | 232572_at | 0.1851 | 0.1685 | |
| GSE77861 | PCA3 | 50652 | 232572_at | -0.1641 | 0.0522 | |
| SRP133303 | PCA3 | 50652 | RNAseq | -0.2582 | 0.3575 | |
| SRP159526 | PCA3 | 50652 | RNAseq | 0.8789 | 0.0636 | |
| SRP193095 | PCA3 | 50652 | RNAseq | 0.1330 | 0.3874 | |
| SRP219564 | PCA3 | 50652 | RNAseq | -0.0493 | 0.9274 | |
| TCGA | PCA3 | 50652 | RNAseq | -2.3478 | 0.0057 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PCA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCA3 | 50652 | 6 | 10 | 14 | |
| GSE20123 | PCA3 | 50652 | 6 | 10 | 14 | |
| GSE43470 | PCA3 | 50652 | 5 | 5 | 33 | |
| GSE46452 | PCA3 | 50652 | 6 | 14 | 39 | |
| GSE47630 | PCA3 | 50652 | 1 | 18 | 21 | |
| GSE54993 | PCA3 | 50652 | 4 | 2 | 64 | |
| GSE54994 | PCA3 | 50652 | 4 | 12 | 37 | |
| GSE60625 | PCA3 | 50652 | 0 | 0 | 11 | |
| GSE74703 | PCA3 | 50652 | 4 | 4 | 28 | |
| GSE74704 | PCA3 | 50652 | 3 | 7 | 10 | |
| TCGA | PCA3 | 50652 | 18 | 28 | 50 |
Total number of gains: 57; Total number of losses: 110; Total Number of normals: 321.
Somatic mutations of PCA3:
Generating mutation plots.
Highly correlated genes for PCA3:
Showing top 20/203 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCA3 | THRA | 0.769887 | 3 | 0 | 3 |
| PCA3 | ANO7 | 0.69322 | 3 | 0 | 3 |
| PCA3 | ARHGAP10 | 0.689847 | 3 | 0 | 3 |
| PCA3 | MCHR2-AS1 | 0.687572 | 3 | 0 | 3 |
| PCA3 | LINC01122 | 0.684708 | 3 | 0 | 3 |
| PCA3 | CADPS | 0.684266 | 3 | 0 | 3 |
| PCA3 | TRNAU1AP | 0.68 | 3 | 0 | 3 |
| PCA3 | NPSR1-AS1 | 0.674834 | 3 | 0 | 3 |
| PCA3 | MAFF | 0.671397 | 3 | 0 | 3 |
| PCA3 | ZNF804B | 0.665534 | 3 | 0 | 3 |
| PCA3 | PHYHD1 | 0.663342 | 3 | 0 | 3 |
| PCA3 | HOXA2 | 0.659456 | 3 | 0 | 3 |
| PCA3 | STX7 | 0.652766 | 3 | 0 | 3 |
| PCA3 | PCAT18 | 0.651034 | 3 | 0 | 3 |
| PCA3 | OR10H3 | 0.650973 | 3 | 0 | 3 |
| PCA3 | APOB | 0.647483 | 4 | 0 | 4 |
| PCA3 | CRB2 | 0.646168 | 3 | 0 | 3 |
| PCA3 | PLA2G12B | 0.644106 | 3 | 0 | 3 |
| PCA3 | SLC22A12 | 0.64326 | 3 | 0 | 3 |
| PCA3 | LINC00494 | 0.642569 | 3 | 0 | 3 |
For details and further investigation, click here
