| Full name: docking protein 2 | Alias Symbol: p56dok-2|Dok-2 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 9046 | HGNC ID: HGNC:2991 | Ensembl Gene: ENSG00000147443 | OMIM ID: 604997 |
| Drug and gene relationship at DGIdb | |||
Expression of DOK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOK2 | 9046 | 214054_at | -0.0031 | 0.9950 | |
| GSE20347 | DOK2 | 9046 | 214054_at | -0.0936 | 0.2184 | |
| GSE23400 | DOK2 | 9046 | 214054_at | -0.0518 | 0.1984 | |
| GSE26886 | DOK2 | 9046 | 214054_at | -0.0380 | 0.8384 | |
| GSE29001 | DOK2 | 9046 | 214054_at | -0.0869 | 0.6874 | |
| GSE38129 | DOK2 | 9046 | 214054_at | -0.2012 | 0.0162 | |
| GSE45670 | DOK2 | 9046 | 214054_at | -0.0037 | 0.9828 | |
| GSE53622 | DOK2 | 9046 | 5916 | 0.2838 | 0.0198 | |
| GSE53624 | DOK2 | 9046 | 5916 | 0.4333 | 0.0001 | |
| GSE63941 | DOK2 | 9046 | 214054_at | 0.0172 | 0.9016 | |
| GSE77861 | DOK2 | 9046 | 214054_at | -0.0998 | 0.4163 | |
| GSE97050 | DOK2 | 9046 | A_23_P134851 | 0.5943 | 0.4285 | |
| SRP064894 | DOK2 | 9046 | RNAseq | 0.8093 | 0.0575 | |
| SRP133303 | DOK2 | 9046 | RNAseq | 0.2303 | 0.5051 | |
| SRP159526 | DOK2 | 9046 | RNAseq | -0.1352 | 0.8265 | |
| SRP193095 | DOK2 | 9046 | RNAseq | 0.2311 | 0.2617 | |
| SRP219564 | DOK2 | 9046 | RNAseq | 1.0145 | 0.1112 | |
| TCGA | DOK2 | 9046 | RNAseq | 0.2242 | 0.1995 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DOK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOK2 | 9046 | 4 | 10 | 16 | |
| GSE20123 | DOK2 | 9046 | 4 | 10 | 16 | |
| GSE43470 | DOK2 | 9046 | 4 | 9 | 30 | |
| GSE46452 | DOK2 | 9046 | 13 | 13 | 33 | |
| GSE47630 | DOK2 | 9046 | 10 | 8 | 22 | |
| GSE54993 | DOK2 | 9046 | 2 | 14 | 54 | |
| GSE54994 | DOK2 | 9046 | 8 | 18 | 27 | |
| GSE60625 | DOK2 | 9046 | 3 | 0 | 8 | |
| GSE74703 | DOK2 | 9046 | 4 | 7 | 25 | |
| GSE74704 | DOK2 | 9046 | 3 | 7 | 10 | |
| TCGA | DOK2 | 9046 | 13 | 43 | 40 |
Total number of gains: 68; Total number of losses: 139; Total Number of normals: 281.
Somatic mutations of DOK2:
Generating mutation plots.
Highly correlated genes for DOK2:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOK2 | LRRC25 | 0.781745 | 3 | 0 | 3 |
| DOK2 | ORM1 | 0.697457 | 3 | 0 | 3 |
| DOK2 | LAIR1 | 0.669679 | 8 | 0 | 8 |
| DOK2 | PCSK6 | 0.65898 | 4 | 0 | 3 |
| DOK2 | TMEM106A | 0.658607 | 4 | 0 | 4 |
| DOK2 | AHSP | 0.656839 | 3 | 0 | 3 |
| DOK2 | MYO1G | 0.656202 | 3 | 0 | 3 |
| DOK2 | MTF1 | 0.654016 | 3 | 0 | 3 |
| DOK2 | SIGLEC12 | 0.648864 | 3 | 0 | 3 |
| DOK2 | PGC | 0.647987 | 3 | 0 | 3 |
| DOK2 | TM4SF5 | 0.640061 | 4 | 0 | 3 |
| DOK2 | TNFSF8 | 0.638998 | 7 | 0 | 7 |
| DOK2 | FABP1 | 0.636963 | 3 | 0 | 3 |
| DOK2 | CACNG3 | 0.634962 | 5 | 0 | 4 |
| DOK2 | CYBB | 0.634467 | 8 | 0 | 7 |
| DOK2 | GLRX | 0.632696 | 4 | 0 | 4 |
| DOK2 | TMEM150B | 0.630891 | 4 | 0 | 3 |
| DOK2 | SLC22A2 | 0.630885 | 4 | 0 | 3 |
| DOK2 | AIF1 | 0.625966 | 10 | 0 | 9 |
| DOK2 | THEMIS2 | 0.625886 | 5 | 0 | 4 |
For details and further investigation, click here
