MAPK8

 

Full name: mitogen-activated protein kinase 8 Alias Symbol: JNK|JNK1|SAPK1
Type: protein-coding gene Cytoband: 10q11.22
Entrez ID: 5599 HGNC ID: HGNC:6881 Ensembl Gene: ENSG00000107643 OMIM ID: 601158
Drug and gene relationship at DGIdb
Screen Evidence:

 

MAPK8 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04210Apoptosis
hsa04310Wnt signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of MAPK8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK8 5599 226048_at 0.1976 0.6545
GSE20347 MAPK8 5599 210477_x_at -0.1618 0.0899
GSE23400 MAPK8 5599 210477_x_at -0.2788 0.0000
GSE26886 MAPK8 5599 226048_at 0.1172 0.6702
GSE29001 MAPK8 5599 210477_x_at -0.4156 0.0141
GSE38129 MAPK8 5599 210477_x_at -0.2271 0.0734
GSE45670 MAPK8 5599 226048_at -0.0325 0.8262
GSE53622 MAPK8 5599 58779 -0.3284 0.0000
GSE53624 MAPK8 5599 58779 -0.2954 0.0000
GSE63941 MAPK8 5599 226048_at -0.0477 0.9347
GSE77861 MAPK8 5599 226048_at -0.2643 0.5265
GSE97050 MAPK8 5599 A_33_P3250289 0.1250 0.8236
SRP007169 MAPK8 5599 RNAseq -1.0002 0.0264
SRP008496 MAPK8 5599 RNAseq -0.7490 0.0046
SRP064894 MAPK8 5599 RNAseq -0.6916 0.0005
SRP133303 MAPK8 5599 RNAseq 0.0799 0.6790
SRP159526 MAPK8 5599 RNAseq -0.6516 0.0000
SRP193095 MAPK8 5599 RNAseq -0.7389 0.0000
SRP219564 MAPK8 5599 RNAseq -0.4322 0.2262
TCGA MAPK8 5599 RNAseq -0.0551 0.4387

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by MAPK8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK8 5599 2 5 23
GSE20123 MAPK8 5599 2 5 23
GSE43470 MAPK8 5599 2 6 35
GSE46452 MAPK8 5599 0 13 46
GSE47630 MAPK8 5599 4 12 24
GSE54993 MAPK8 5599 9 0 61
GSE54994 MAPK8 5599 2 10 41
GSE60625 MAPK8 5599 0 0 11
GSE74703 MAPK8 5599 2 3 31
GSE74704 MAPK8 5599 1 4 15
TCGA MAPK8 5599 13 22 61

Total number of gains: 37; Total number of losses: 80; Total Number of normals: 371.  

 

Somatic mutations of MAPK8:

 

Generating mutation plots.

 

Highly correlated genes for MAPK8:

 

Showing top 20/419 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK8RPP380.708823303
MAPK8PDCD60.704319303
MAPK8ATP6V1A0.692751303
MAPK8NR6A10.691377303
MAPK8OTOR0.688136404
MAPK8UBA60.685635303
MAPK8MITD10.684381303
MAPK8C1orf740.681795303
MAPK8MCU0.680657303
MAPK8TTC220.672317404
MAPK8MTAP0.670195404
MAPK8SIT10.670092303
MAPK8ZCCHC80.669765303
MAPK8FTSJ10.667279303
MAPK8C1orf500.665374303
MAPK8HEYL0.66386404
MAPK8ODF2L0.662342303
MAPK8BRINP20.658404403
MAPK8CYLC10.657832404
MAPK8SCYL20.657343403

For details and further investigation, click here