| Full name: phosphodiesterase 10A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 10846 | HGNC ID: HGNC:8772 | Ensembl Gene: ENSG00000112541 | OMIM ID: 610652 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE10A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE10A | 10846 | 205501_at | -0.0713 | 0.9367 | |
| GSE20347 | PDE10A | 10846 | 211171_s_at | -0.0391 | 0.6238 | |
| GSE23400 | PDE10A | 10846 | 211171_s_at | -0.0472 | 0.2981 | |
| GSE26886 | PDE10A | 10846 | 211171_s_at | -0.0785 | 0.5457 | |
| GSE29001 | PDE10A | 10846 | 211171_s_at | 0.0634 | 0.7934 | |
| GSE38129 | PDE10A | 10846 | 211171_s_at | -0.0048 | 0.9514 | |
| GSE45670 | PDE10A | 10846 | 205501_at | -0.1447 | 0.7793 | |
| GSE53622 | PDE10A | 10846 | 18024 | 0.4346 | 0.0111 | |
| GSE53624 | PDE10A | 10846 | 14762 | 0.1180 | 0.2166 | |
| GSE63941 | PDE10A | 10846 | 205501_at | -3.1440 | 0.0050 | |
| GSE77861 | PDE10A | 10846 | 211171_s_at | -0.1136 | 0.2054 | |
| GSE97050 | PDE10A | 10846 | A_23_P356677 | 1.2287 | 0.0660 | |
| SRP007169 | PDE10A | 10846 | RNAseq | 0.6980 | 0.2063 | |
| SRP008496 | PDE10A | 10846 | RNAseq | 2.4350 | 0.0000 | |
| SRP064894 | PDE10A | 10846 | RNAseq | 1.0426 | 0.0056 | |
| SRP133303 | PDE10A | 10846 | RNAseq | 1.2545 | 0.0008 | |
| SRP159526 | PDE10A | 10846 | RNAseq | 0.1001 | 0.8176 | |
| SRP193095 | PDE10A | 10846 | RNAseq | 0.7684 | 0.0026 | |
| SRP219564 | PDE10A | 10846 | RNAseq | 0.9094 | 0.0696 | |
| TCGA | PDE10A | 10846 | RNAseq | -0.3098 | 0.1146 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by PDE10A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE10A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE10A | 10846 | 2 | 5 | 23 | |
| GSE20123 | PDE10A | 10846 | 2 | 4 | 24 | |
| GSE43470 | PDE10A | 10846 | 3 | 0 | 40 | |
| GSE46452 | PDE10A | 10846 | 3 | 10 | 46 | |
| GSE47630 | PDE10A | 10846 | 7 | 7 | 26 | |
| GSE54993 | PDE10A | 10846 | 4 | 4 | 62 | |
| GSE54994 | PDE10A | 10846 | 9 | 8 | 36 | |
| GSE60625 | PDE10A | 10846 | 1 | 1 | 9 | |
| GSE74703 | PDE10A | 10846 | 3 | 0 | 33 | |
| GSE74704 | PDE10A | 10846 | 1 | 2 | 17 | |
| TCGA | PDE10A | 10846 | 13 | 21 | 62 |
Total number of gains: 48; Total number of losses: 62; Total Number of normals: 378.
Somatic mutations of PDE10A:
Generating mutation plots.
Highly correlated genes for PDE10A:
Showing top 20/177 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE10A | PITHD1 | 0.726883 | 3 | 0 | 3 |
| PDE10A | ANKRD13A | 0.707917 | 3 | 0 | 3 |
| PDE10A | ACOX1 | 0.695592 | 3 | 0 | 3 |
| PDE10A | DNAH1 | 0.689471 | 3 | 0 | 3 |
| PDE10A | MPND | 0.681725 | 3 | 0 | 3 |
| PDE10A | NMNAT2 | 0.678963 | 3 | 0 | 3 |
| PDE10A | FIBCD1 | 0.675343 | 3 | 0 | 3 |
| PDE10A | WASL | 0.670986 | 3 | 0 | 3 |
| PDE10A | ARHGAP17 | 0.668409 | 4 | 0 | 4 |
| PDE10A | DNAJC21 | 0.661368 | 3 | 0 | 3 |
| PDE10A | SOCS6 | 0.660863 | 3 | 0 | 3 |
| PDE10A | COPS7A | 0.660503 | 3 | 0 | 3 |
| PDE10A | PCAT18 | 0.66019 | 3 | 0 | 3 |
| PDE10A | LPIN2 | 0.657869 | 3 | 0 | 3 |
| PDE10A | PDK2 | 0.657171 | 3 | 0 | 3 |
| PDE10A | CCNDBP1 | 0.651755 | 3 | 0 | 3 |
| PDE10A | TMEM167B | 0.650133 | 3 | 0 | 3 |
| PDE10A | CAPZB | 0.649517 | 3 | 0 | 3 |
| PDE10A | PEG10 | 0.647538 | 5 | 0 | 3 |
| PDE10A | ZNF521 | 0.64696 | 3 | 0 | 3 |
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