| Full name: leukocyte immunoglobulin like receptor B4 | Alias Symbol: LIR-5|ILT3|HM18|LIR5|CD85k | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 11006 | HGNC ID: HGNC:6608 | Ensembl Gene: ENSG00000186818 | OMIM ID: 604821 |
| Drug and gene relationship at DGIdb | |||
LILRB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of LILRB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LILRB4 | 11006 | 210152_at | 0.3473 | 0.4284 | |
| GSE20347 | LILRB4 | 11006 | 210152_at | 0.0033 | 0.9690 | |
| GSE23400 | LILRB4 | 11006 | 210152_at | 0.0096 | 0.8386 | |
| GSE26886 | LILRB4 | 11006 | 210152_at | -0.0517 | 0.7566 | |
| GSE29001 | LILRB4 | 11006 | 210152_at | 0.1205 | 0.4003 | |
| GSE38129 | LILRB4 | 11006 | 210152_at | 0.2063 | 0.0985 | |
| GSE45670 | LILRB4 | 11006 | 210152_at | 0.0427 | 0.7723 | |
| GSE53622 | LILRB4 | 11006 | 89141 | 0.6812 | 0.0001 | |
| GSE53624 | LILRB4 | 11006 | 89141 | 0.9717 | 0.0000 | |
| GSE63941 | LILRB4 | 11006 | 210152_at | 0.3107 | 0.0544 | |
| GSE77861 | LILRB4 | 11006 | 210152_at | -0.1990 | 0.2050 | |
| GSE97050 | LILRB4 | 11006 | A_33_P3267799 | 0.7640 | 0.1806 | |
| SRP007169 | LILRB4 | 11006 | RNAseq | 5.3126 | 0.0000 | |
| SRP008496 | LILRB4 | 11006 | RNAseq | 4.9161 | 0.0000 | |
| SRP064894 | LILRB4 | 11006 | RNAseq | 2.6417 | 0.0000 | |
| SRP133303 | LILRB4 | 11006 | RNAseq | 1.4649 | 0.0000 | |
| SRP159526 | LILRB4 | 11006 | RNAseq | 2.1887 | 0.0190 | |
| SRP193095 | LILRB4 | 11006 | RNAseq | 1.3006 | 0.0000 | |
| SRP219564 | LILRB4 | 11006 | RNAseq | 1.9046 | 0.0133 | |
| TCGA | LILRB4 | 11006 | RNAseq | 0.9866 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by LILRB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LILRB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LILRB4 | 11006 | 3 | 4 | 23 | |
| GSE20123 | LILRB4 | 11006 | 3 | 3 | 24 | |
| GSE43470 | LILRB4 | 11006 | 2 | 11 | 30 | |
| GSE46452 | LILRB4 | 11006 | 45 | 1 | 13 | |
| GSE47630 | LILRB4 | 11006 | 8 | 6 | 26 | |
| GSE54993 | LILRB4 | 11006 | 17 | 4 | 49 | |
| GSE54994 | LILRB4 | 11006 | 4 | 13 | 36 | |
| GSE60625 | LILRB4 | 11006 | 9 | 0 | 2 | |
| GSE74703 | LILRB4 | 11006 | 2 | 7 | 27 | |
| GSE74704 | LILRB4 | 11006 | 3 | 1 | 16 | |
| TCGA | LILRB4 | 11006 | 19 | 14 | 63 |
Total number of gains: 115; Total number of losses: 64; Total Number of normals: 309.
Somatic mutations of LILRB4:
Generating mutation plots.
Highly correlated genes for LILRB4:
Showing top 20/322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LILRB4 | LILRB1 | 0.717997 | 9 | 0 | 9 |
| LILRB4 | TMEM150B | 0.704285 | 3 | 0 | 3 |
| LILRB4 | LRRC25 | 0.700721 | 4 | 0 | 3 |
| LILRB4 | LAIR1 | 0.685894 | 10 | 0 | 8 |
| LILRB4 | CYBB | 0.685214 | 8 | 0 | 7 |
| LILRB4 | HOXD8 | 0.679633 | 3 | 0 | 3 |
| LILRB4 | PDIA3 | 0.677184 | 3 | 0 | 3 |
| LILRB4 | PARVG | 0.676312 | 6 | 0 | 6 |
| LILRB4 | MS4A7 | 0.671352 | 3 | 0 | 3 |
| LILRB4 | MS4A4A | 0.671138 | 6 | 0 | 5 |
| LILRB4 | PIK3AP1 | 0.668698 | 5 | 0 | 4 |
| LILRB4 | FCGR3A | 0.663713 | 3 | 0 | 3 |
| LILRB4 | IFI35 | 0.659874 | 5 | 0 | 5 |
| LILRB4 | SUSD2 | 0.65903 | 3 | 0 | 3 |
| LILRB4 | C19orf38 | 0.655222 | 3 | 0 | 3 |
| LILRB4 | APOC1 | 0.651757 | 6 | 0 | 6 |
| LILRB4 | SLAMF8 | 0.651543 | 10 | 0 | 8 |
| LILRB4 | GRINA | 0.649661 | 3 | 0 | 3 |
| LILRB4 | EOMES | 0.649446 | 3 | 0 | 3 |
| LILRB4 | CD163 | 0.648674 | 6 | 0 | 5 |
For details and further investigation, click here
