| Full name: peptidylprolyl isomerase B | Alias Symbol: CYPB|OI9|PPIase|B|CYP-S1|SCYLP | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 5479 | HGNC ID: HGNC:9255 | Ensembl Gene: ENSG00000166794 | OMIM ID: 123841 |
| Drug and gene relationship at DGIdb | |||
Expression of PPIB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPIB | 5479 | 200967_at | 0.2874 | 0.1799 | |
| GSE20347 | PPIB | 5479 | 200967_at | 0.1651 | 0.4655 | |
| GSE23400 | PPIB | 5479 | 200967_at | 0.4653 | 0.0000 | |
| GSE26886 | PPIB | 5479 | 200967_at | -0.1648 | 0.5369 | |
| GSE29001 | PPIB | 5479 | 200967_at | 0.0544 | 0.9162 | |
| GSE38129 | PPIB | 5479 | 200967_at | 0.4005 | 0.0238 | |
| GSE45670 | PPIB | 5479 | 200967_at | 0.3808 | 0.0040 | |
| GSE53622 | PPIB | 5479 | 83531 | 0.5434 | 0.0000 | |
| GSE53624 | PPIB | 5479 | 83531 | 0.5257 | 0.0000 | |
| GSE63941 | PPIB | 5479 | 200967_at | -0.9893 | 0.0044 | |
| GSE77861 | PPIB | 5479 | 200967_at | 0.2467 | 0.2562 | |
| GSE97050 | PPIB | 5479 | A_24_P304723 | 0.8525 | 0.0944 | |
| SRP007169 | PPIB | 5479 | RNAseq | -0.5660 | 0.0663 | |
| SRP008496 | PPIB | 5479 | RNAseq | -0.3827 | 0.0564 | |
| SRP064894 | PPIB | 5479 | RNAseq | 1.0264 | 0.0009 | |
| SRP133303 | PPIB | 5479 | RNAseq | 0.7578 | 0.0001 | |
| SRP159526 | PPIB | 5479 | RNAseq | 0.2652 | 0.3567 | |
| SRP193095 | PPIB | 5479 | RNAseq | 0.0673 | 0.6719 | |
| SRP219564 | PPIB | 5479 | RNAseq | 0.8001 | 0.0074 | |
| TCGA | PPIB | 5479 | RNAseq | 0.1072 | 0.0230 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PPIB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPIB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPIB | 5479 | 7 | 3 | 20 | |
| GSE20123 | PPIB | 5479 | 7 | 3 | 20 | |
| GSE43470 | PPIB | 5479 | 4 | 6 | 33 | |
| GSE46452 | PPIB | 5479 | 3 | 7 | 49 | |
| GSE47630 | PPIB | 5479 | 8 | 10 | 22 | |
| GSE54993 | PPIB | 5479 | 5 | 6 | 59 | |
| GSE54994 | PPIB | 5479 | 6 | 8 | 39 | |
| GSE60625 | PPIB | 5479 | 4 | 0 | 7 | |
| GSE74703 | PPIB | 5479 | 4 | 3 | 29 | |
| GSE74704 | PPIB | 5479 | 3 | 3 | 14 | |
| TCGA | PPIB | 5479 | 10 | 17 | 69 |
Total number of gains: 61; Total number of losses: 66; Total Number of normals: 361.
Somatic mutations of PPIB:
Generating mutation plots.
Highly correlated genes for PPIB:
Showing top 20/778 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPIB | DGKQ | 0.757994 | 3 | 0 | 3 |
| PPIB | DHRS13 | 0.735286 | 3 | 0 | 3 |
| PPIB | GEMIN5 | 0.721929 | 3 | 0 | 3 |
| PPIB | SLC9A1 | 0.717048 | 4 | 0 | 4 |
| PPIB | TTYH3 | 0.704237 | 5 | 0 | 5 |
| PPIB | AGTRAP | 0.703754 | 3 | 0 | 3 |
| PPIB | ZNF469 | 0.699681 | 6 | 0 | 6 |
| PPIB | HSP90B1 | 0.696536 | 7 | 0 | 6 |
| PPIB | SPON2 | 0.688591 | 3 | 0 | 3 |
| PPIB | CPSF3 | 0.686964 | 5 | 0 | 5 |
| PPIB | DCAF13 | 0.684126 | 5 | 0 | 5 |
| PPIB | WDR54 | 0.683216 | 5 | 0 | 5 |
| PPIB | SNX30 | 0.677863 | 3 | 0 | 3 |
| PPIB | TBX1 | 0.677638 | 4 | 0 | 4 |
| PPIB | MYO1B | 0.674416 | 6 | 0 | 5 |
| PPIB | DCBLD1 | 0.672767 | 6 | 0 | 5 |
| PPIB | PDIA3 | 0.671972 | 10 | 0 | 7 |
| PPIB | STEAP1B | 0.670574 | 4 | 0 | 3 |
| PPIB | KNSTRN | 0.670572 | 5 | 0 | 4 |
| PPIB | CYP27C1 | 0.6684 | 4 | 0 | 3 |
For details and further investigation, click here
