CCNE2

 

Full name: cyclin E2 Alias Symbol: CYCE2
Type: protein-coding gene Cytoband: 8q22.1
Entrez ID: 9134 HGNC ID: HGNC:1590 Ensembl Gene: ENSG00000175305 OMIM ID: 603775
Drug and gene relationship at DGIdb
Screen Evidence:

 

CCNE2 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa05162Measles
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05222Small cell lung cancer

 

Expression of CCNE2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCNE2 9134 205034_at 1.6546 0.0600
GSE20347 CCNE2 9134 205034_at 1.2700 0.0001
GSE23400 CCNE2 9134 211814_s_at 0.4526 0.0000
GSE26886 CCNE2 9134 205034_at -0.0601 0.9074
GSE29001 CCNE2 9134 205034_at 1.3672 0.0181
GSE38129 CCNE2 9134 205034_at 1.6612 0.0000
GSE45670 CCNE2 9134 205034_at 1.1717 0.0001
GSE53622 CCNE2 9134 46024 1.1457 0.0000
GSE53624 CCNE2 9134 46024 1.3298 0.0000
GSE63941 CCNE2 9134 205034_at 2.3632 0.0056
GSE77861 CCNE2 9134 205034_at 0.2393 0.5585
GSE97050 CCNE2 9134 A_33_P3217819 1.0016 0.1958
SRP007169 CCNE2 9134 RNAseq 0.8981 0.0662
SRP008496 CCNE2 9134 RNAseq 0.7481 0.0521
SRP133303 CCNE2 9134 RNAseq 0.9821 0.0002
SRP159526 CCNE2 9134 RNAseq 0.6320 0.0877
SRP193095 CCNE2 9134 RNAseq 0.3104 0.0724
SRP219564 CCNE2 9134 RNAseq 0.1288 0.8645
TCGA CCNE2 9134 RNAseq 0.5818 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by CCNE2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCNE2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCNE2 9134 16 0 14
GSE20123 CCNE2 9134 17 0 13
GSE43470 CCNE2 9134 21 1 21
GSE46452 CCNE2 9134 23 0 36
GSE47630 CCNE2 9134 24 0 16
GSE54993 CCNE2 9134 0 20 50
GSE54994 CCNE2 9134 34 1 18
GSE60625 CCNE2 9134 0 4 7
GSE74703 CCNE2 9134 18 1 17
GSE74704 CCNE2 9134 12 0 8
TCGA CCNE2 9134 56 1 39

Total number of gains: 221; Total number of losses: 28; Total Number of normals: 239.  

 

Somatic mutations of CCNE2:

 

Generating mutation plots.

 

Highly correlated genes for CCNE2:

 

Showing top 20/1026 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCNE2MCM40.74761211010
CCNE2NEK20.73016511011
CCNE2ATAD20.71618313012
CCNE2MTERF30.715325707
CCNE2PDIA30.714874303
CCNE2STIL0.71297911010
CCNE2CENPI0.7088481009
CCNE2TNFAIP8L10.707624404
CCNE2XPO50.706768605
CCNE2FASTKD10.705915404
CCNE2KIF150.70278311011
CCNE2PRKDC0.7010511009
CCNE2IQGAP30.70036606
CCNE2CDCA50.697774605
CCNE2LY6K0.697668303
CCNE2CENPF0.69685912011
CCNE2CMSS10.695529404
CCNE2RMI10.69385311010
CCNE2RAD51AP10.69280412010
CCNE2UHRF10.690793806

For details and further investigation, click here