OAS3

 

Full name: 2'-5'-oligoadenylate synthetase 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 12q24.13
Entrez ID: 4940 HGNC ID: HGNC:8088 Ensembl Gene: ENSG00000111331 OMIM ID: 603351
Drug and gene relationship at DGIdb

 

OAS3 involved pathways:

KEGG pathway Description View
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of OAS3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 OAS3 4940 218400_at 0.6765 0.1982
GSE20347 OAS3 4940 218400_at 0.5915 0.0289
GSE23400 OAS3 4940 218400_at 0.6606 0.0000
GSE26886 OAS3 4940 218400_at 0.6481 0.0455
GSE29001 OAS3 4940 218400_at 0.8372 0.0148
GSE38129 OAS3 4940 218400_at 0.7744 0.0008
GSE45670 OAS3 4940 218400_at 1.6882 0.0000
GSE53622 OAS3 4940 68222 0.9471 0.0000
GSE53624 OAS3 4940 68222 0.9682 0.0000
GSE63941 OAS3 4940 218400_at 1.4520 0.1712
GSE77861 OAS3 4940 218400_at 0.3977 0.1379
GSE97050 OAS3 4940 A_33_P3402489 0.8559 0.2503
SRP007169 OAS3 4940 RNAseq 2.9770 0.0001
SRP008496 OAS3 4940 RNAseq 2.2160 0.0000
SRP064894 OAS3 4940 RNAseq 1.6355 0.0000
SRP133303 OAS3 4940 RNAseq 0.9385 0.0019
SRP159526 OAS3 4940 RNAseq -0.5463 0.3619
SRP193095 OAS3 4940 RNAseq 1.1402 0.0000
SRP219564 OAS3 4940 RNAseq 0.8966 0.3236
TCGA OAS3 4940 RNAseq 0.4408 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by OAS3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of OAS3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 OAS3 4940 4 3 23
GSE20123 OAS3 4940 4 3 23
GSE43470 OAS3 4940 2 0 41
GSE46452 OAS3 4940 9 1 49
GSE47630 OAS3 4940 9 3 28
GSE54993 OAS3 4940 0 5 65
GSE54994 OAS3 4940 4 2 47
GSE60625 OAS3 4940 0 0 11
GSE74703 OAS3 4940 2 0 34
GSE74704 OAS3 4940 2 2 16
TCGA OAS3 4940 22 11 63

Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.  

 

Somatic mutations of OAS3:

 

Generating mutation plots.

 

Highly correlated genes for OAS3:

 

Showing top 20/534 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
OAS3OAS20.76787413012
OAS3USP410.73264303
OAS3DDX600.7288913013
OAS3STAT10.72766112012
OAS3MX10.72140910010
OAS3IFI440.71876213012
OAS3HELZ20.715302606
OAS3UBE2L60.71196613012
OAS3ISG150.7067313013
OAS3DTX3L0.704301807
OAS3RSAD20.70093512011
OAS3IFIH10.6975911010
OAS3LAMP30.6975613011
OAS3PARP120.69545513013
OAS3IFI44L0.69365912011
OAS3OASL0.6933912010
OAS3PARP90.687214807
OAS3USP180.68687812011
OAS3DDX60L0.686818706
OAS3ACVR1C0.684918303

For details and further investigation, click here