BAD

 

Full name: BCL2 associated agonist of cell death Alias Symbol: BCL2L8|BBC2
Type: protein-coding gene Cytoband: 11q13.1
Entrez ID: 572 HGNC ID: HGNC:936 Ensembl Gene: ENSG00000002330 OMIM ID: 603167
Drug and gene relationship at DGIdb

 

BAD involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer

 

Expression of BAD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BAD 572 209364_at 0.1260 0.8112
GSE20347 BAD 572 1861_at -0.1085 0.6172
GSE23400 BAD 572 209364_at -0.0563 0.3975
GSE26886 BAD 572 209364_at 0.9004 0.0000
GSE29001 BAD 572 209364_at -0.1490 0.5024
GSE38129 BAD 572 1861_at -0.0498 0.8182
GSE45670 BAD 572 209364_at -0.0855 0.4660
GSE53622 BAD 572 41913 -0.1201 0.2264
GSE53624 BAD 572 41913 0.1618 0.0795
GSE63941 BAD 572 209364_at 0.2249 0.6286
GSE77861 BAD 572 209364_at 0.1068 0.5947
GSE97050 BAD 572 A_33_P3402076 -0.0212 0.9523
SRP007169 BAD 572 RNAseq -1.2454 0.0067
SRP008496 BAD 572 RNAseq -0.2563 0.6136
SRP064894 BAD 572 RNAseq -0.3012 0.4110
SRP133303 BAD 572 RNAseq 0.0826 0.7082
SRP159526 BAD 572 RNAseq 0.1680 0.5393
SRP193095 BAD 572 RNAseq -0.3106 0.0521
SRP219564 BAD 572 RNAseq -0.3952 0.3819
TCGA BAD 572 RNAseq -0.0884 0.1157

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by BAD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BAD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BAD 572 6 5 19
GSE20123 BAD 572 6 5 19
GSE43470 BAD 572 1 3 39
GSE46452 BAD 572 8 4 47
GSE47630 BAD 572 4 6 30
GSE54993 BAD 572 3 0 67
GSE54994 BAD 572 5 5 43
GSE60625 BAD 572 0 4 7
GSE74703 BAD 572 1 1 34
GSE74704 BAD 572 4 3 13
TCGA BAD 572 20 9 67

Total number of gains: 58; Total number of losses: 45; Total Number of normals: 385.  

 

Somatic mutations of BAD:

 

Generating mutation plots.

 

Highly correlated genes for BAD:

 

Showing top 20/380 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BADCPT1A0.844211303
BADDLG50.774364303
BADABCB60.762586303
BADHOXA70.76198303
BADCPSF60.75743303
BADMRPL470.756284303
BADFADD0.752885303
BADITGB80.750774303
BADPDPR0.747856303
BADRBM40.745801303
BADZHX20.733475303
BADPSMG30.73284404
BADALCAM0.73124303
BADFKTN0.73113303
BADFAM86C10.727094303
BADPARL0.725471303
BADLOXL40.722656303
BADRNF1300.719562303
BADMRPL210.718265303
BADNCOR20.717344303

For details and further investigation, click here