| Full name: PDS5 cohesin associated factor A | Alias Symbol: KIAA0648|PIG54|SCC-112 | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 23244 | HGNC ID: HGNC:29088 | Ensembl Gene: ENSG00000121892 | OMIM ID: 613200 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PDS5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDS5A | 23244 | 212138_at | 0.2363 | 0.4884 | |
| GSE20347 | PDS5A | 23244 | 212138_at | -0.2369 | 0.0029 | |
| GSE23400 | PDS5A | 23244 | 212138_at | 0.1461 | 0.0864 | |
| GSE26886 | PDS5A | 23244 | 212140_at | -0.2520 | 0.2002 | |
| GSE29001 | PDS5A | 23244 | 212138_at | 0.1729 | 0.3631 | |
| GSE38129 | PDS5A | 23244 | 212138_at | -0.0635 | 0.6574 | |
| GSE45670 | PDS5A | 23244 | 212138_at | -0.0510 | 0.6919 | |
| GSE53622 | PDS5A | 23244 | 34597 | -0.0343 | 0.7813 | |
| GSE53624 | PDS5A | 23244 | 64800 | -0.5188 | 0.0000 | |
| GSE63941 | PDS5A | 23244 | 212138_at | 0.3614 | 0.2018 | |
| GSE77861 | PDS5A | 23244 | 212140_at | -0.3441 | 0.1865 | |
| GSE97050 | PDS5A | 23244 | A_24_P52004 | -0.3693 | 0.2874 | |
| SRP007169 | PDS5A | 23244 | RNAseq | -0.4859 | 0.1822 | |
| SRP008496 | PDS5A | 23244 | RNAseq | -0.2973 | 0.1894 | |
| SRP064894 | PDS5A | 23244 | RNAseq | -0.3734 | 0.0365 | |
| SRP133303 | PDS5A | 23244 | RNAseq | -0.2455 | 0.0229 | |
| SRP159526 | PDS5A | 23244 | RNAseq | -0.2859 | 0.0845 | |
| SRP193095 | PDS5A | 23244 | RNAseq | -0.4662 | 0.0000 | |
| SRP219564 | PDS5A | 23244 | RNAseq | -0.1954 | 0.5113 | |
| TCGA | PDS5A | 23244 | RNAseq | 0.0137 | 0.7410 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDS5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDS5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDS5A | 23244 | 0 | 16 | 14 | |
| GSE20123 | PDS5A | 23244 | 0 | 16 | 14 | |
| GSE43470 | PDS5A | 23244 | 0 | 15 | 28 | |
| GSE46452 | PDS5A | 23244 | 1 | 36 | 22 | |
| GSE47630 | PDS5A | 23244 | 1 | 19 | 20 | |
| GSE54993 | PDS5A | 23244 | 7 | 0 | 63 | |
| GSE54994 | PDS5A | 23244 | 3 | 10 | 40 | |
| GSE60625 | PDS5A | 23244 | 0 | 0 | 11 | |
| GSE74703 | PDS5A | 23244 | 0 | 12 | 24 | |
| GSE74704 | PDS5A | 23244 | 0 | 9 | 11 | |
| TCGA | PDS5A | 23244 | 10 | 45 | 41 |
Total number of gains: 22; Total number of losses: 178; Total Number of normals: 288.
Somatic mutations of PDS5A:
Generating mutation plots.
Highly correlated genes for PDS5A:
Showing top 20/271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDS5A | SAMD8 | 0.736008 | 3 | 0 | 3 |
| PDS5A | ZNF710 | 0.685394 | 4 | 0 | 3 |
| PDS5A | RPS23 | 0.684995 | 3 | 0 | 3 |
| PDS5A | UNC5B | 0.684747 | 3 | 0 | 3 |
| PDS5A | CXCL16 | 0.675197 | 3 | 0 | 3 |
| PDS5A | PGM1 | 0.673811 | 4 | 0 | 3 |
| PDS5A | FYTTD1 | 0.671633 | 3 | 0 | 3 |
| PDS5A | PTRHD1 | 0.665555 | 4 | 0 | 3 |
| PDS5A | THAP2 | 0.661628 | 4 | 0 | 3 |
| PDS5A | LPAR3 | 0.659801 | 3 | 0 | 3 |
| PDS5A | C8orf44 | 0.654932 | 3 | 0 | 3 |
| PDS5A | MRPL13 | 0.654567 | 4 | 0 | 3 |
| PDS5A | TMF1 | 0.647297 | 4 | 0 | 3 |
| PDS5A | SUB1 | 0.646073 | 4 | 0 | 3 |
| PDS5A | ZFP3 | 0.643548 | 3 | 0 | 3 |
| PDS5A | IER3IP1 | 0.642975 | 4 | 0 | 3 |
| PDS5A | ERCC4 | 0.637485 | 3 | 0 | 3 |
| PDS5A | DIAPH1 | 0.637121 | 5 | 0 | 4 |
| PDS5A | TOM1L1 | 0.634732 | 4 | 0 | 3 |
| PDS5A | MYO6 | 0.633593 | 4 | 0 | 4 |
For details and further investigation, click here
