| Full name: myosin VI | Alias Symbol: KIAA0389 | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 4646 | HGNC ID: HGNC:7605 | Ensembl Gene: ENSG00000196586 | OMIM ID: 600970 |
| Drug and gene relationship at DGIdb | |||
Expression of MYO6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYO6 | 4646 | 203216_s_at | -0.5656 | 0.6018 | |
| GSE20347 | MYO6 | 4646 | 203216_s_at | -1.2014 | 0.0001 | |
| GSE23400 | MYO6 | 4646 | 203216_s_at | -1.3999 | 0.0000 | |
| GSE26886 | MYO6 | 4646 | 203216_s_at | -1.2899 | 0.0000 | |
| GSE29001 | MYO6 | 4646 | 203216_s_at | -1.0178 | 0.0010 | |
| GSE38129 | MYO6 | 4646 | 203216_s_at | -0.6824 | 0.0247 | |
| GSE45670 | MYO6 | 4646 | 203216_s_at | -0.2578 | 0.3448 | |
| GSE53622 | MYO6 | 4646 | 76330 | -0.7958 | 0.0000 | |
| GSE53624 | MYO6 | 4646 | 76330 | -1.5968 | 0.0000 | |
| GSE63941 | MYO6 | 4646 | 203216_s_at | -0.6642 | 0.1671 | |
| GSE77861 | MYO6 | 4646 | 203216_s_at | -1.0729 | 0.0314 | |
| GSE97050 | MYO6 | 4646 | A_33_P3539345 | -0.2217 | 0.7065 | |
| SRP007169 | MYO6 | 4646 | RNAseq | -1.9606 | 0.0001 | |
| SRP008496 | MYO6 | 4646 | RNAseq | -2.0246 | 0.0000 | |
| SRP064894 | MYO6 | 4646 | RNAseq | -1.9352 | 0.0000 | |
| SRP133303 | MYO6 | 4646 | RNAseq | -0.5952 | 0.0014 | |
| SRP159526 | MYO6 | 4646 | RNAseq | -1.4072 | 0.0000 | |
| SRP193095 | MYO6 | 4646 | RNAseq | -1.2689 | 0.0000 | |
| SRP219564 | MYO6 | 4646 | RNAseq | -1.5315 | 0.0066 | |
| TCGA | MYO6 | 4646 | RNAseq | -0.1494 | 0.0316 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by MYO6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYO6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYO6 | 4646 | 1 | 3 | 26 | |
| GSE20123 | MYO6 | 4646 | 1 | 2 | 27 | |
| GSE43470 | MYO6 | 4646 | 3 | 0 | 40 | |
| GSE46452 | MYO6 | 4646 | 2 | 11 | 46 | |
| GSE47630 | MYO6 | 4646 | 8 | 4 | 28 | |
| GSE54993 | MYO6 | 4646 | 3 | 2 | 65 | |
| GSE54994 | MYO6 | 4646 | 8 | 7 | 38 | |
| GSE60625 | MYO6 | 4646 | 0 | 1 | 10 | |
| GSE74703 | MYO6 | 4646 | 3 | 0 | 33 | |
| GSE74704 | MYO6 | 4646 | 0 | 1 | 19 | |
| TCGA | MYO6 | 4646 | 9 | 20 | 67 |
Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.
Somatic mutations of MYO6:
Generating mutation plots.
Highly correlated genes for MYO6:
Showing top 20/1497 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYO6 | USP6NL | 0.820069 | 12 | 0 | 12 |
| MYO6 | TAB3 | 0.794239 | 8 | 0 | 8 |
| MYO6 | MYO5B | 0.77943 | 6 | 0 | 6 |
| MYO6 | SPNS2 | 0.778938 | 5 | 0 | 5 |
| MYO6 | BLNK | 0.777513 | 11 | 0 | 11 |
| MYO6 | ARHGAP27 | 0.77679 | 7 | 0 | 7 |
| MYO6 | ESPL1 | 0.767925 | 10 | 0 | 10 |
| MYO6 | WWC1 | 0.763205 | 11 | 0 | 11 |
| MYO6 | CHP1 | 0.76307 | 10 | 0 | 10 |
| MYO6 | TTC9 | 0.756564 | 11 | 0 | 11 |
| MYO6 | RANBP9 | 0.756183 | 12 | 0 | 11 |
| MYO6 | RAB11A | 0.753336 | 11 | 0 | 11 |
| MYO6 | C18orf25 | 0.749885 | 11 | 0 | 11 |
| MYO6 | VPS4B | 0.749582 | 12 | 0 | 11 |
| MYO6 | PHACTR4 | 0.745891 | 11 | 0 | 11 |
| MYO6 | ITSN2 | 0.745057 | 11 | 0 | 11 |
| MYO6 | NT5C2 | 0.744292 | 12 | 0 | 11 |
| MYO6 | C15orf62 | 0.743113 | 7 | 0 | 7 |
| MYO6 | PDCD6IP | 0.740129 | 11 | 0 | 11 |
| MYO6 | GRHL1 | 0.739666 | 8 | 0 | 8 |
For details and further investigation, click here
