| Full name: PDZ domain containing 3 | Alias Symbol: FLJ22756|IKEPP | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 79849 | HGNC ID: HGNC:19891 | Ensembl Gene: ENSG00000172367 | OMIM ID: 607146 |
| Drug and gene relationship at DGIdb | |||
Expression of PDZD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDZD3 | 79849 | 220303_at | 0.0158 | 0.9611 | |
| GSE20347 | PDZD3 | 79849 | 220303_at | 0.1306 | 0.2116 | |
| GSE23400 | PDZD3 | 79849 | 220303_at | -0.1575 | 0.0007 | |
| GSE26886 | PDZD3 | 79849 | 220303_at | -0.1967 | 0.1238 | |
| GSE29001 | PDZD3 | 79849 | 220303_at | 0.2157 | 0.2846 | |
| GSE38129 | PDZD3 | 79849 | 220303_at | -0.0311 | 0.7549 | |
| GSE45670 | PDZD3 | 79849 | 220303_at | 0.0243 | 0.7852 | |
| GSE63941 | PDZD3 | 79849 | 220303_at | -0.0323 | 0.8748 | |
| GSE77861 | PDZD3 | 79849 | 220303_at | -0.0459 | 0.6894 | |
| TCGA | PDZD3 | 79849 | RNAseq | -3.5070 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PDZD3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PDZD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDZD3 | 79849 | 1 | 11 | 18 | |
| GSE20123 | PDZD3 | 79849 | 1 | 11 | 18 | |
| GSE43470 | PDZD3 | 79849 | 2 | 8 | 33 | |
| GSE46452 | PDZD3 | 79849 | 3 | 26 | 30 | |
| GSE47630 | PDZD3 | 79849 | 2 | 19 | 19 | |
| GSE54993 | PDZD3 | 79849 | 10 | 0 | 60 | |
| GSE54994 | PDZD3 | 79849 | 5 | 19 | 29 | |
| GSE60625 | PDZD3 | 79849 | 0 | 3 | 8 | |
| GSE74703 | PDZD3 | 79849 | 1 | 5 | 30 | |
| GSE74704 | PDZD3 | 79849 | 0 | 7 | 13 | |
| TCGA | PDZD3 | 79849 | 4 | 51 | 41 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of PDZD3:
Generating mutation plots.
Highly correlated genes for PDZD3:
Showing top 20/694 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDZD3 | GALR1 | 0.701492 | 3 | 0 | 3 |
| PDZD3 | GAD2 | 0.70007 | 6 | 0 | 6 |
| PDZD3 | RNASE3 | 0.692679 | 6 | 0 | 6 |
| PDZD3 | SYN1 | 0.687712 | 4 | 0 | 3 |
| PDZD3 | OR10H1 | 0.679099 | 5 | 0 | 4 |
| PDZD3 | SOAT2 | 0.679004 | 5 | 0 | 5 |
| PDZD3 | CMKLR1 | 0.675577 | 5 | 0 | 5 |
| PDZD3 | NTNG1 | 0.674233 | 4 | 0 | 4 |
| PDZD3 | RPGRIP1 | 0.670378 | 5 | 0 | 4 |
| PDZD3 | KCNF1 | 0.668731 | 4 | 0 | 4 |
| PDZD3 | SLC8A1 | 0.666939 | 5 | 0 | 5 |
| PDZD3 | DPF3 | 0.666451 | 4 | 0 | 3 |
| PDZD3 | UBE2D4 | 0.662847 | 5 | 0 | 4 |
| PDZD3 | SLC6A12 | 0.662728 | 4 | 0 | 4 |
| PDZD3 | RXRG | 0.662013 | 5 | 0 | 5 |
| PDZD3 | CLDN11 | 0.661946 | 4 | 0 | 4 |
| PDZD3 | CTNND2 | 0.661661 | 4 | 0 | 4 |
| PDZD3 | PPP1R37 | 0.661168 | 3 | 0 | 3 |
| PDZD3 | DAB1 | 0.660474 | 4 | 0 | 4 |
| PDZD3 | KCNJ10 | 0.6589 | 4 | 0 | 4 |
For details and further investigation, click here
