| Full name: pelota mRNA surveillance and ribosome rescue factor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 53918 | HGNC ID: HGNC:8829 | Ensembl Gene: ENSG00000152684 | OMIM ID: 605757 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PELO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PELO | 53918 | 218472_s_at | -0.6285 | 0.2322 | |
| GSE20347 | PELO | 53918 | 218472_s_at | -0.0143 | 0.9579 | |
| GSE23400 | PELO | 53918 | 218472_s_at | 0.1121 | 0.1376 | |
| GSE26886 | PELO | 53918 | 218472_s_at | -0.1814 | 0.4856 | |
| GSE29001 | PELO | 53918 | 218472_s_at | 0.0320 | 0.9400 | |
| GSE38129 | PELO | 53918 | 218472_s_at | -0.1218 | 0.6810 | |
| GSE45670 | PELO | 53918 | 218472_s_at | -0.2047 | 0.3368 | |
| GSE53622 | PELO | 53918 | 49011 | -0.1905 | 0.0161 | |
| GSE53624 | PELO | 53918 | 49011 | 0.0361 | 0.6325 | |
| GSE63941 | PELO | 53918 | 218472_s_at | -1.2352 | 0.0270 | |
| GSE77861 | PELO | 53918 | 218472_s_at | 0.0925 | 0.8006 | |
| GSE97050 | PELO | 53918 | A_23_P58763 | -0.3697 | 0.2797 | |
| SRP007169 | PELO | 53918 | RNAseq | 0.2658 | 0.5601 | |
| SRP008496 | PELO | 53918 | RNAseq | 0.3322 | 0.3042 | |
| SRP064894 | PELO | 53918 | RNAseq | -0.0152 | 0.9355 | |
| SRP133303 | PELO | 53918 | RNAseq | 0.1662 | 0.4196 | |
| SRP159526 | PELO | 53918 | RNAseq | -0.0768 | 0.8285 | |
| SRP193095 | PELO | 53918 | RNAseq | 0.0573 | 0.6328 | |
| SRP219564 | PELO | 53918 | RNAseq | -0.4058 | 0.4353 | |
| TCGA | PELO | 53918 | RNAseq | -0.0135 | 0.8106 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PELO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PELO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PELO | 53918 | 2 | 11 | 17 | |
| GSE20123 | PELO | 53918 | 2 | 11 | 17 | |
| GSE43470 | PELO | 53918 | 1 | 12 | 30 | |
| GSE46452 | PELO | 53918 | 1 | 27 | 31 | |
| GSE47630 | PELO | 53918 | 2 | 16 | 22 | |
| GSE54993 | PELO | 53918 | 8 | 1 | 61 | |
| GSE54994 | PELO | 53918 | 5 | 17 | 31 | |
| GSE60625 | PELO | 53918 | 0 | 0 | 11 | |
| GSE74703 | PELO | 53918 | 1 | 9 | 26 | |
| GSE74704 | PELO | 53918 | 2 | 5 | 13 | |
| TCGA | PELO | 53918 | 10 | 45 | 41 |
Total number of gains: 34; Total number of losses: 154; Total Number of normals: 300.
Somatic mutations of PELO:
Generating mutation plots.
Highly correlated genes for PELO:
Showing top 20/750 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PELO | HOXA4 | 0.75793 | 3 | 0 | 3 |
| PELO | RSL24D1 | 0.737312 | 5 | 0 | 5 |
| PELO | RNASE4 | 0.735376 | 5 | 0 | 4 |
| PELO | CHL1 | 0.725554 | 3 | 0 | 3 |
| PELO | TUBB2A | 0.710453 | 3 | 0 | 3 |
| PELO | NLGN4Y | 0.707839 | 3 | 0 | 3 |
| PELO | ANG | 0.697949 | 5 | 0 | 4 |
| PELO | HAGH | 0.695462 | 4 | 0 | 3 |
| PELO | SSC5D | 0.690027 | 3 | 0 | 3 |
| PELO | RAP1A | 0.688622 | 4 | 0 | 3 |
| PELO | KLF6 | 0.685594 | 3 | 0 | 3 |
| PELO | FUNDC2 | 0.68551 | 5 | 0 | 4 |
| PELO | KDSR | 0.685297 | 4 | 0 | 3 |
| PELO | RAPGEF6 | 0.676098 | 3 | 0 | 3 |
| PELO | GMPR | 0.675656 | 3 | 0 | 3 |
| PELO | TRAF6 | 0.672804 | 4 | 0 | 3 |
| PELO | MOCS2 | 0.671708 | 11 | 0 | 11 |
| PELO | TRPC6 | 0.670687 | 5 | 0 | 4 |
| PELO | COX7A1 | 0.669878 | 6 | 0 | 5 |
| PELO | PEG3 | 0.668642 | 4 | 0 | 4 |
For details and further investigation, click here
