| Full name: Kruppel like factor 6 | Alias Symbol: CPBP|GBF|Zf9|PAC1 | ||
| Type: protein-coding gene | Cytoband: 10p15.2 | ||
| Entrez ID: 1316 | HGNC ID: HGNC:2235 | Ensembl Gene: ENSG00000067082 | OMIM ID: 602053 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KLF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLF6 | 1316 | 1555832_s_at | -0.9505 | 0.0981 | |
| GSE20347 | KLF6 | 1316 | 208961_s_at | -1.2429 | 0.0000 | |
| GSE23400 | KLF6 | 1316 | 208961_s_at | -0.8178 | 0.0000 | |
| GSE26886 | KLF6 | 1316 | 1555832_s_at | -1.2429 | 0.0003 | |
| GSE29001 | KLF6 | 1316 | 208961_s_at | -1.4065 | 0.0013 | |
| GSE38129 | KLF6 | 1316 | 208961_s_at | -1.0595 | 0.0000 | |
| GSE45670 | KLF6 | 1316 | 1555832_s_at | -0.9200 | 0.0003 | |
| GSE53622 | KLF6 | 1316 | 119832 | -1.1402 | 0.0000 | |
| GSE53624 | KLF6 | 1316 | 119832 | -0.8069 | 0.0000 | |
| GSE63941 | KLF6 | 1316 | 1555832_s_at | -2.1795 | 0.0260 | |
| GSE77861 | KLF6 | 1316 | 1555832_s_at | -0.5003 | 0.2240 | |
| GSE97050 | KLF6 | 1316 | A_23_P63798 | -0.4830 | 0.2516 | |
| SRP007169 | KLF6 | 1316 | RNAseq | -2.1172 | 0.0000 | |
| SRP008496 | KLF6 | 1316 | RNAseq | -2.0042 | 0.0000 | |
| SRP064894 | KLF6 | 1316 | RNAseq | -0.2984 | 0.2860 | |
| SRP133303 | KLF6 | 1316 | RNAseq | -0.5722 | 0.0459 | |
| SRP159526 | KLF6 | 1316 | RNAseq | -1.2779 | 0.0192 | |
| SRP193095 | KLF6 | 1316 | RNAseq | -0.5061 | 0.0252 | |
| SRP219564 | KLF6 | 1316 | RNAseq | -0.5950 | 0.1544 | |
| TCGA | KLF6 | 1316 | RNAseq | -0.1711 | 0.0128 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by KLF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLF6 | 1316 | 5 | 8 | 17 | |
| GSE20123 | KLF6 | 1316 | 5 | 7 | 18 | |
| GSE43470 | KLF6 | 1316 | 3 | 6 | 34 | |
| GSE46452 | KLF6 | 1316 | 2 | 14 | 43 | |
| GSE47630 | KLF6 | 1316 | 6 | 14 | 20 | |
| GSE54993 | KLF6 | 1316 | 11 | 0 | 59 | |
| GSE54994 | KLF6 | 1316 | 4 | 10 | 39 | |
| GSE60625 | KLF6 | 1316 | 0 | 0 | 11 | |
| GSE74703 | KLF6 | 1316 | 2 | 4 | 30 | |
| GSE74704 | KLF6 | 1316 | 1 | 6 | 13 | |
| TCGA | KLF6 | 1316 | 18 | 26 | 52 |
Total number of gains: 57; Total number of losses: 95; Total Number of normals: 336.
Somatic mutations of KLF6:
Generating mutation plots.
Highly correlated genes for KLF6:
Showing top 20/987 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLF6 | USP2 | 0.783554 | 4 | 0 | 4 |
| KLF6 | PALMD | 0.722607 | 10 | 0 | 10 |
| KLF6 | C9orf47 | 0.72103 | 4 | 0 | 3 |
| KLF6 | BHLHE40 | 0.719584 | 11 | 0 | 11 |
| KLF6 | PRDM8 | 0.70729 | 3 | 0 | 3 |
| KLF6 | GNG12 | 0.701543 | 10 | 0 | 10 |
| KLF6 | TBC1D23 | 0.700087 | 3 | 0 | 3 |
| KLF6 | CSRNP1 | 0.699903 | 8 | 0 | 7 |
| KLF6 | DUSP1 | 0.688833 | 12 | 0 | 10 |
| KLF6 | KCNB1 | 0.688731 | 4 | 0 | 4 |
| KLF6 | TIRAP | 0.685683 | 3 | 0 | 3 |
| KLF6 | PELO | 0.685594 | 3 | 0 | 3 |
| KLF6 | NME9 | 0.679909 | 3 | 0 | 3 |
| KLF6 | PDCD4 | 0.676413 | 4 | 0 | 4 |
| KLF6 | CHRM2 | 0.67594 | 3 | 0 | 3 |
| KLF6 | SGMS2 | 0.675761 | 7 | 0 | 7 |
| KLF6 | SLMAP | 0.672264 | 7 | 0 | 7 |
| KLF6 | TOB1 | 0.672202 | 10 | 0 | 10 |
| KLF6 | HSPB8 | 0.671695 | 10 | 0 | 9 |
| KLF6 | CCL14 | 0.670316 | 3 | 0 | 3 |
For details and further investigation, click here
