| Full name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: Xp11.21 | ||
| Entrez ID: 5207 | HGNC ID: HGNC:8872 | Ensembl Gene: ENSG00000158571 | OMIM ID: 311790 |
| Drug and gene relationship at DGIdb | |||
PFKFB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04922 | Glucagon signaling pathway |
Expression of PFKFB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFKFB1 | 5207 | 207537_at | -0.0283 | 0.9352 | |
| GSE20347 | PFKFB1 | 5207 | 207537_at | -0.1046 | 0.2968 | |
| GSE23400 | PFKFB1 | 5207 | 207537_at | -0.1249 | 0.0005 | |
| GSE26886 | PFKFB1 | 5207 | 207537_at | -0.1316 | 0.3701 | |
| GSE29001 | PFKFB1 | 5207 | 207537_at | -0.1614 | 0.2013 | |
| GSE38129 | PFKFB1 | 5207 | 207537_at | -0.2339 | 0.0779 | |
| GSE45670 | PFKFB1 | 5207 | 207537_at | 0.0768 | 0.5714 | |
| GSE53622 | PFKFB1 | 5207 | 31479 | -0.1773 | 0.1814 | |
| GSE53624 | PFKFB1 | 5207 | 31479 | -0.3484 | 0.0006 | |
| GSE63941 | PFKFB1 | 5207 | 207537_at | 0.2406 | 0.1070 | |
| GSE77861 | PFKFB1 | 5207 | 207537_at | -0.0634 | 0.5775 | |
| TCGA | PFKFB1 | 5207 | RNAseq | 1.3250 | 0.0067 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PFKFB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFKFB1:
No record found for this gene.
Somatic mutations of PFKFB1:
Generating mutation plots.
Highly correlated genes for PFKFB1:
Showing top 20/738 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFKFB1 | TMEM169 | 0.707163 | 3 | 0 | 3 |
| PFKFB1 | MRVI1-AS1 | 0.681062 | 3 | 0 | 3 |
| PFKFB1 | FLI1 | 0.668449 | 3 | 0 | 3 |
| PFKFB1 | SYT13 | 0.659471 | 3 | 0 | 3 |
| PFKFB1 | THEG | 0.658205 | 6 | 0 | 5 |
| PFKFB1 | CBL | 0.654265 | 4 | 0 | 4 |
| PFKFB1 | IRS4 | 0.639102 | 4 | 0 | 4 |
| PFKFB1 | ADM2 | 0.638166 | 4 | 0 | 4 |
| PFKFB1 | NCR1 | 0.637194 | 5 | 0 | 5 |
| PFKFB1 | FANCD2OS | 0.635727 | 3 | 0 | 3 |
| PFKFB1 | PIK3R5 | 0.633875 | 4 | 0 | 4 |
| PFKFB1 | CCDC70 | 0.631858 | 6 | 0 | 6 |
| PFKFB1 | OR2H2 | 0.631019 | 6 | 0 | 5 |
| PFKFB1 | TMPRSS15 | 0.630384 | 5 | 0 | 5 |
| PFKFB1 | EPOR | 0.628509 | 8 | 0 | 6 |
| PFKFB1 | ADPRH | 0.628454 | 7 | 0 | 6 |
| PFKFB1 | C8A | 0.627099 | 7 | 0 | 6 |
| PFKFB1 | SPAG11A | 0.624765 | 5 | 0 | 5 |
| PFKFB1 | PSG1 | 0.621175 | 7 | 0 | 6 |
| PFKFB1 | P2RX6 | 0.61898 | 6 | 0 | 5 |
For details and further investigation, click here
