| Full name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10p15.1 | ||
| Entrez ID: 5209 | HGNC ID: HGNC:8874 | Ensembl Gene: ENSG00000170525 | OMIM ID: 605319 |
| Drug and gene relationship at DGIdb | |||
PFKFB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04152 | AMPK signaling pathway |
Expression of PFKFB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFKFB3 | 5209 | 202464_s_at | -0.6985 | 0.4062 | |
| GSE20347 | PFKFB3 | 5209 | 202464_s_at | -0.3025 | 0.2767 | |
| GSE23400 | PFKFB3 | 5209 | 202464_s_at | 0.0110 | 0.9180 | |
| GSE26886 | PFKFB3 | 5209 | 202464_s_at | -0.6864 | 0.0437 | |
| GSE29001 | PFKFB3 | 5209 | 202464_s_at | -0.4524 | 0.1701 | |
| GSE38129 | PFKFB3 | 5209 | 202464_s_at | -0.0766 | 0.7831 | |
| GSE45670 | PFKFB3 | 5209 | 202464_s_at | 0.2925 | 0.3696 | |
| GSE53622 | PFKFB3 | 5209 | 35900 | 0.1710 | 0.1278 | |
| GSE53624 | PFKFB3 | 5209 | 66742 | -0.2606 | 0.0023 | |
| GSE63941 | PFKFB3 | 5209 | 202464_s_at | -0.7420 | 0.3474 | |
| GSE77861 | PFKFB3 | 5209 | 202464_s_at | -0.5991 | 0.2651 | |
| GSE97050 | PFKFB3 | 5209 | A_24_P206604 | 0.4745 | 0.1318 | |
| SRP007169 | PFKFB3 | 5209 | RNAseq | -0.3117 | 0.4166 | |
| SRP008496 | PFKFB3 | 5209 | RNAseq | -0.7962 | 0.0044 | |
| SRP064894 | PFKFB3 | 5209 | RNAseq | -0.6709 | 0.0526 | |
| SRP133303 | PFKFB3 | 5209 | RNAseq | -0.0666 | 0.7756 | |
| SRP159526 | PFKFB3 | 5209 | RNAseq | -1.1715 | 0.0036 | |
| SRP193095 | PFKFB3 | 5209 | RNAseq | 0.3173 | 0.1492 | |
| SRP219564 | PFKFB3 | 5209 | RNAseq | -1.2754 | 0.0442 | |
| TCGA | PFKFB3 | 5209 | RNAseq | -0.0708 | 0.2754 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PFKFB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFKFB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PFKFB3 | 5209 | 4 | 8 | 18 | |
| GSE20123 | PFKFB3 | 5209 | 4 | 7 | 19 | |
| GSE43470 | PFKFB3 | 5209 | 3 | 6 | 34 | |
| GSE46452 | PFKFB3 | 5209 | 2 | 14 | 43 | |
| GSE47630 | PFKFB3 | 5209 | 5 | 15 | 20 | |
| GSE54993 | PFKFB3 | 5209 | 11 | 0 | 59 | |
| GSE54994 | PFKFB3 | 5209 | 4 | 10 | 39 | |
| GSE60625 | PFKFB3 | 5209 | 0 | 0 | 11 | |
| GSE74703 | PFKFB3 | 5209 | 2 | 4 | 30 | |
| GSE74704 | PFKFB3 | 5209 | 1 | 7 | 12 | |
| TCGA | PFKFB3 | 5209 | 19 | 25 | 52 |
Total number of gains: 55; Total number of losses: 96; Total Number of normals: 337.
Somatic mutations of PFKFB3:
Generating mutation plots.
Highly correlated genes for PFKFB3:
Showing top 20/210 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFKFB3 | SUGT1 | 0.726754 | 3 | 0 | 3 |
| PFKFB3 | TAS2R5 | 0.714895 | 3 | 0 | 3 |
| PFKFB3 | ATP6AP1 | 0.706815 | 3 | 0 | 3 |
| PFKFB3 | PFDN1 | 0.701234 | 3 | 0 | 3 |
| PFKFB3 | KIAA1191 | 0.696794 | 3 | 0 | 3 |
| PFKFB3 | MAML2 | 0.695901 | 3 | 0 | 3 |
| PFKFB3 | C3orf80 | 0.685428 | 4 | 0 | 4 |
| PFKFB3 | TSG101 | 0.682619 | 3 | 0 | 3 |
| PFKFB3 | ANKRD9 | 0.680122 | 3 | 0 | 3 |
| PFKFB3 | PGM1 | 0.67707 | 3 | 0 | 3 |
| PFKFB3 | CRYZ | 0.673492 | 3 | 0 | 3 |
| PFKFB3 | PHKB | 0.672305 | 3 | 0 | 3 |
| PFKFB3 | LDHD | 0.662766 | 3 | 0 | 3 |
| PFKFB3 | EIF4E2 | 0.657433 | 4 | 0 | 4 |
| PFKFB3 | VTI1B | 0.656795 | 3 | 0 | 3 |
| PFKFB3 | GSTO2 | 0.65386 | 3 | 0 | 3 |
| PFKFB3 | LEPROT | 0.653178 | 4 | 0 | 3 |
| PFKFB3 | AP3S1 | 0.650037 | 6 | 0 | 5 |
| PFKFB3 | RBKS | 0.649026 | 4 | 0 | 3 |
| PFKFB3 | SLU7 | 0.645795 | 4 | 0 | 4 |
For details and further investigation, click here
