| Full name: tumor susceptibility 101 | Alias Symbol: VPS23 | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 7251 | HGNC ID: HGNC:15971 | Ensembl Gene: ENSG00000074319 | OMIM ID: 601387 |
| Drug and gene relationship at DGIdb | |||
Expression of TSG101:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSG101 | 7251 | 201758_at | -0.4999 | 0.1009 | |
| GSE20347 | TSG101 | 7251 | 201758_at | -1.0176 | 0.0000 | |
| GSE23400 | TSG101 | 7251 | 201758_at | -0.6724 | 0.0000 | |
| GSE26886 | TSG101 | 7251 | 201758_at | -0.9094 | 0.0000 | |
| GSE29001 | TSG101 | 7251 | 201758_at | -0.7840 | 0.0001 | |
| GSE38129 | TSG101 | 7251 | 201758_at | -0.6728 | 0.0000 | |
| GSE45670 | TSG101 | 7251 | 201758_at | -0.4590 | 0.0040 | |
| GSE53622 | TSG101 | 7251 | 48526 | -0.4568 | 0.0000 | |
| GSE53624 | TSG101 | 7251 | 48526 | -0.7843 | 0.0000 | |
| GSE63941 | TSG101 | 7251 | 201758_at | 0.2535 | 0.4401 | |
| GSE77861 | TSG101 | 7251 | 201758_at | -0.4413 | 0.2912 | |
| GSE97050 | TSG101 | 7251 | A_23_P75839 | -0.2804 | 0.3649 | |
| SRP007169 | TSG101 | 7251 | RNAseq | -1.8688 | 0.0001 | |
| SRP008496 | TSG101 | 7251 | RNAseq | -1.7324 | 0.0000 | |
| SRP064894 | TSG101 | 7251 | RNAseq | -0.8926 | 0.0000 | |
| SRP133303 | TSG101 | 7251 | RNAseq | -0.3050 | 0.1546 | |
| SRP159526 | TSG101 | 7251 | RNAseq | -0.9737 | 0.0019 | |
| SRP193095 | TSG101 | 7251 | RNAseq | -0.9029 | 0.0000 | |
| SRP219564 | TSG101 | 7251 | RNAseq | -0.8733 | 0.0100 | |
| TCGA | TSG101 | 7251 | RNAseq | -0.0115 | 0.8105 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TSG101 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSG101:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSG101 | 7251 | 0 | 10 | 20 | |
| GSE20123 | TSG101 | 7251 | 0 | 10 | 20 | |
| GSE43470 | TSG101 | 7251 | 1 | 5 | 37 | |
| GSE46452 | TSG101 | 7251 | 7 | 5 | 47 | |
| GSE47630 | TSG101 | 7251 | 3 | 10 | 27 | |
| GSE54993 | TSG101 | 7251 | 3 | 0 | 67 | |
| GSE54994 | TSG101 | 7251 | 2 | 13 | 38 | |
| GSE60625 | TSG101 | 7251 | 0 | 0 | 11 | |
| GSE74703 | TSG101 | 7251 | 1 | 3 | 32 | |
| GSE74704 | TSG101 | 7251 | 0 | 9 | 11 | |
| TCGA | TSG101 | 7251 | 11 | 29 | 56 |
Total number of gains: 28; Total number of losses: 94; Total Number of normals: 366.
Somatic mutations of TSG101:
Generating mutation plots.
Highly correlated genes for TSG101:
Showing top 20/1598 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSG101 | RNF141 | 0.800976 | 11 | 0 | 11 |
| TSG101 | NAGK | 0.793031 | 11 | 0 | 11 |
| TSG101 | C18orf25 | 0.788653 | 11 | 0 | 11 |
| TSG101 | TPD52L2 | 0.783176 | 3 | 0 | 3 |
| TSG101 | GYS2 | 0.774799 | 10 | 0 | 9 |
| TSG101 | DHRS1 | 0.773399 | 9 | 0 | 9 |
| TSG101 | TMEM9B | 0.773226 | 11 | 0 | 11 |
| TSG101 | RAB11A | 0.767877 | 11 | 0 | 11 |
| TSG101 | NUCB2 | 0.767479 | 11 | 0 | 11 |
| TSG101 | ZDHHC13 | 0.760722 | 13 | 0 | 13 |
| TSG101 | PRSS3 | 0.7605 | 10 | 0 | 10 |
| TSG101 | CCNYL1 | 0.759876 | 5 | 0 | 5 |
| TSG101 | TOM1 | 0.759848 | 11 | 0 | 11 |
| TSG101 | UBL3 | 0.759623 | 11 | 0 | 10 |
| TSG101 | FBXO3 | 0.758305 | 12 | 0 | 12 |
| TSG101 | ELOVL1 | 0.758115 | 3 | 0 | 3 |
| TSG101 | VPS4B | 0.757332 | 12 | 0 | 12 |
| TSG101 | TMOD3 | 0.754386 | 10 | 0 | 10 |
| TSG101 | YOD1 | 0.752992 | 11 | 0 | 11 |
| TSG101 | SASH1 | 0.751842 | 11 | 0 | 11 |
For details and further investigation, click here
