| Full name: phosphofructokinase, platelet | Alias Symbol: PFK-C|PFKF | ||
| Type: protein-coding gene | Cytoband: 10p15.2 | ||
| Entrez ID: 5214 | HGNC ID: HGNC:8878 | Ensembl Gene: ENSG00000067057 | OMIM ID: 171840 |
| Drug and gene relationship at DGIdb | |||
PFKP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway |
Expression of PFKP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFKP | 5214 | 201037_at | -0.3553 | 0.4570 | |
| GSE20347 | PFKP | 5214 | 201037_at | -0.1342 | 0.6001 | |
| GSE23400 | PFKP | 5214 | 201037_at | 0.1204 | 0.2830 | |
| GSE26886 | PFKP | 5214 | 201037_at | -0.3444 | 0.0529 | |
| GSE29001 | PFKP | 5214 | 201037_at | -0.2051 | 0.6301 | |
| GSE38129 | PFKP | 5214 | 201037_at | 0.0333 | 0.8760 | |
| GSE45670 | PFKP | 5214 | 201037_at | -0.0499 | 0.8840 | |
| GSE53622 | PFKP | 5214 | 23064 | -0.0670 | 0.5344 | |
| GSE53624 | PFKP | 5214 | 23064 | 0.0395 | 0.6081 | |
| GSE63941 | PFKP | 5214 | 201037_at | 0.1518 | 0.7836 | |
| GSE77861 | PFKP | 5214 | 201037_at | 0.1172 | 0.8228 | |
| GSE97050 | PFKP | 5214 | A_33_P3413962 | 0.1631 | 0.4285 | |
| SRP007169 | PFKP | 5214 | RNAseq | -0.5261 | 0.1682 | |
| SRP008496 | PFKP | 5214 | RNAseq | -0.7520 | 0.0003 | |
| SRP064894 | PFKP | 5214 | RNAseq | -0.1995 | 0.3226 | |
| SRP133303 | PFKP | 5214 | RNAseq | 0.0720 | 0.6162 | |
| SRP159526 | PFKP | 5214 | RNAseq | -0.3452 | 0.4969 | |
| SRP193095 | PFKP | 5214 | RNAseq | 0.0942 | 0.5673 | |
| SRP219564 | PFKP | 5214 | RNAseq | -0.6813 | 0.1482 | |
| TCGA | PFKP | 5214 | RNAseq | 0.2506 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PFKP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFKP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PFKP | 5214 | 5 | 8 | 17 | |
| GSE20123 | PFKP | 5214 | 5 | 7 | 18 | |
| GSE43470 | PFKP | 5214 | 3 | 6 | 34 | |
| GSE46452 | PFKP | 5214 | 2 | 14 | 43 | |
| GSE47630 | PFKP | 5214 | 6 | 14 | 20 | |
| GSE54993 | PFKP | 5214 | 11 | 0 | 59 | |
| GSE54994 | PFKP | 5214 | 4 | 10 | 39 | |
| GSE60625 | PFKP | 5214 | 0 | 0 | 11 | |
| GSE74703 | PFKP | 5214 | 2 | 4 | 30 | |
| GSE74704 | PFKP | 5214 | 1 | 6 | 13 | |
| TCGA | PFKP | 5214 | 18 | 27 | 51 |
Total number of gains: 57; Total number of losses: 96; Total Number of normals: 335.
Somatic mutations of PFKP:
Generating mutation plots.
Highly correlated genes for PFKP:
Showing top 20/146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFKP | RPL8 | 0.776068 | 3 | 0 | 3 |
| PFKP | PHF3 | 0.760657 | 3 | 0 | 3 |
| PFKP | VKORC1 | 0.755961 | 3 | 0 | 3 |
| PFKP | GPCPD1 | 0.751447 | 3 | 0 | 3 |
| PFKP | CNOT1 | 0.73088 | 3 | 0 | 3 |
| PFKP | CHURC1 | 0.706763 | 3 | 0 | 3 |
| PFKP | CYLD | 0.706649 | 3 | 0 | 3 |
| PFKP | FAM114A2 | 0.69768 | 3 | 0 | 3 |
| PFKP | LTBP2 | 0.69715 | 3 | 0 | 3 |
| PFKP | RPS14 | 0.689819 | 4 | 0 | 4 |
| PFKP | PITPNC1 | 0.688976 | 3 | 0 | 3 |
| PFKP | ZNF581 | 0.688729 | 3 | 0 | 3 |
| PFKP | NDUFA10 | 0.682468 | 3 | 0 | 3 |
| PFKP | EDEM1 | 0.680432 | 3 | 0 | 3 |
| PFKP | POLR2C | 0.680298 | 3 | 0 | 3 |
| PFKP | EDNRB | 0.676093 | 3 | 0 | 3 |
| PFKP | FOXC1 | 0.673721 | 3 | 0 | 3 |
| PFKP | TRIP12 | 0.671919 | 3 | 0 | 3 |
| PFKP | CTSB | 0.671842 | 3 | 0 | 3 |
| PFKP | ZNF503 | 0.670858 | 3 | 0 | 3 |
For details and further investigation, click here
