| Full name: cathepsin B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 1508 | HGNC ID: HGNC:2527 | Ensembl Gene: ENSG00000164733 | OMIM ID: 116810 |
| Related drugs: CHEMBL2028907, CHEMBL222649, COUMARIN, UREA... [more] | |||
CTSB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04612 | Antigen processing and presentation |
Expression of CTSB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTSB | 1508 | 200839_s_at | 0.6908 | 0.1601 | |
| GSE20347 | CTSB | 1508 | 200839_s_at | 0.2250 | 0.3509 | |
| GSE23400 | CTSB | 1508 | 200839_s_at | 0.5350 | 0.0000 | |
| GSE26886 | CTSB | 1508 | 200839_s_at | 0.1726 | 0.4665 | |
| GSE29001 | CTSB | 1508 | 200839_s_at | 0.1574 | 0.6976 | |
| GSE38129 | CTSB | 1508 | 200839_s_at | 0.4849 | 0.0074 | |
| GSE45670 | CTSB | 1508 | 200839_s_at | 0.4968 | 0.0034 | |
| GSE53622 | CTSB | 1508 | 31250 | 0.4084 | 0.0000 | |
| GSE53624 | CTSB | 1508 | 31250 | 0.3517 | 0.0000 | |
| GSE63941 | CTSB | 1508 | 200839_s_at | -1.3237 | 0.0915 | |
| GSE77861 | CTSB | 1508 | 200839_s_at | 0.6977 | 0.0432 | |
| GSE97050 | CTSB | 1508 | A_33_P3287631 | 0.3407 | 0.1870 | |
| SRP007169 | CTSB | 1508 | RNAseq | -0.2226 | 0.6805 | |
| SRP008496 | CTSB | 1508 | RNAseq | 0.2211 | 0.6343 | |
| SRP064894 | CTSB | 1508 | RNAseq | 1.0583 | 0.0000 | |
| SRP133303 | CTSB | 1508 | RNAseq | 0.9824 | 0.0007 | |
| SRP159526 | CTSB | 1508 | RNAseq | 0.5339 | 0.2654 | |
| SRP193095 | CTSB | 1508 | RNAseq | 0.7042 | 0.0031 | |
| SRP219564 | CTSB | 1508 | RNAseq | 0.8287 | 0.0354 | |
| TCGA | CTSB | 1508 | RNAseq | 0.2713 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CTSB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CTSB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTSB | 1508 | 4 | 10 | 16 | |
| GSE20123 | CTSB | 1508 | 4 | 10 | 16 | |
| GSE43470 | CTSB | 1508 | 4 | 9 | 30 | |
| GSE46452 | CTSB | 1508 | 12 | 14 | 33 | |
| GSE47630 | CTSB | 1508 | 10 | 7 | 23 | |
| GSE54993 | CTSB | 1508 | 3 | 14 | 53 | |
| GSE54994 | CTSB | 1508 | 8 | 19 | 26 | |
| GSE60625 | CTSB | 1508 | 3 | 0 | 8 | |
| GSE74703 | CTSB | 1508 | 4 | 7 | 25 | |
| GSE74704 | CTSB | 1508 | 3 | 7 | 10 | |
| TCGA | CTSB | 1508 | 14 | 39 | 43 |
Total number of gains: 69; Total number of losses: 136; Total Number of normals: 283.
Somatic mutations of CTSB:
Generating mutation plots.
Highly correlated genes for CTSB:
Showing top 20/648 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTSB | NUS1 | 0.798548 | 3 | 0 | 3 |
| CTSB | AGTRAP | 0.739966 | 4 | 0 | 4 |
| CTSB | CPT1A | 0.738088 | 3 | 0 | 3 |
| CTSB | MOB3A | 0.736994 | 3 | 0 | 3 |
| CTSB | KREMEN1 | 0.732547 | 3 | 0 | 3 |
| CTSB | HAS3 | 0.707201 | 4 | 0 | 3 |
| CTSB | FLNB | 0.693665 | 5 | 0 | 4 |
| CTSB | BZW1 | 0.688964 | 3 | 0 | 3 |
| CTSB | OSBPL6 | 0.683078 | 3 | 0 | 3 |
| CTSB | PPP1R14C | 0.680167 | 4 | 0 | 3 |
| CTSB | MRPL52 | 0.679676 | 3 | 0 | 3 |
| CTSB | FANCB | 0.678947 | 3 | 0 | 3 |
| CTSB | C8orf76 | 0.678841 | 4 | 0 | 4 |
| CTSB | IFFO2 | 0.678769 | 3 | 0 | 3 |
| CTSB | ENO2 | 0.678254 | 3 | 0 | 3 |
| CTSB | RNF4 | 0.673834 | 4 | 0 | 3 |
| CTSB | ARL6IP6 | 0.673407 | 4 | 0 | 3 |
| CTSB | WDR54 | 0.67242 | 5 | 0 | 4 |
| CTSB | PFKP | 0.671842 | 3 | 0 | 3 |
| CTSB | TPM3 | 0.669119 | 5 | 0 | 5 |
For details and further investigation, click here
