| Full name: progesterone receptor membrane component 2 | Alias Symbol: PMBP|DG6 | ||
| Type: protein-coding gene | Cytoband: 4q28.2 | ||
| Entrez ID: 10424 | HGNC ID: HGNC:16089 | Ensembl Gene: ENSG00000164040 | OMIM ID: 607735 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PGRMC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGRMC2 | 10424 | 213227_at | -0.8417 | 0.0446 | |
| GSE20347 | PGRMC2 | 10424 | 213227_at | -1.1951 | 0.0000 | |
| GSE23400 | PGRMC2 | 10424 | 201701_s_at | -0.1679 | 0.0005 | |
| GSE26886 | PGRMC2 | 10424 | 201701_s_at | -0.3179 | 0.1245 | |
| GSE29001 | PGRMC2 | 10424 | 213227_at | -0.7127 | 0.0065 | |
| GSE38129 | PGRMC2 | 10424 | 213227_at | -1.1885 | 0.0000 | |
| GSE45670 | PGRMC2 | 10424 | 213227_at | -1.0625 | 0.0000 | |
| GSE53622 | PGRMC2 | 10424 | 56090 | -0.4863 | 0.0000 | |
| GSE53624 | PGRMC2 | 10424 | 56090 | -0.5691 | 0.0000 | |
| GSE63941 | PGRMC2 | 10424 | 201701_s_at | -2.3420 | 0.0006 | |
| GSE77861 | PGRMC2 | 10424 | 213227_at | -0.6073 | 0.0492 | |
| GSE97050 | PGRMC2 | 10424 | A_23_P155868 | -0.4884 | 0.1133 | |
| SRP007169 | PGRMC2 | 10424 | RNAseq | -0.8144 | 0.0272 | |
| SRP008496 | PGRMC2 | 10424 | RNAseq | -0.9068 | 0.0005 | |
| SRP064894 | PGRMC2 | 10424 | RNAseq | -0.4234 | 0.0006 | |
| SRP133303 | PGRMC2 | 10424 | RNAseq | -0.3424 | 0.0237 | |
| SRP159526 | PGRMC2 | 10424 | RNAseq | -0.7243 | 0.0000 | |
| SRP193095 | PGRMC2 | 10424 | RNAseq | -0.9894 | 0.0000 | |
| SRP219564 | PGRMC2 | 10424 | RNAseq | -0.5852 | 0.0468 | |
| TCGA | PGRMC2 | 10424 | RNAseq | -0.2418 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PGRMC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PGRMC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGRMC2 | 10424 | 0 | 12 | 18 | |
| GSE20123 | PGRMC2 | 10424 | 0 | 12 | 18 | |
| GSE43470 | PGRMC2 | 10424 | 0 | 12 | 31 | |
| GSE46452 | PGRMC2 | 10424 | 1 | 36 | 22 | |
| GSE47630 | PGRMC2 | 10424 | 0 | 22 | 18 | |
| GSE54993 | PGRMC2 | 10424 | 9 | 0 | 61 | |
| GSE54994 | PGRMC2 | 10424 | 1 | 15 | 37 | |
| GSE60625 | PGRMC2 | 10424 | 0 | 1 | 10 | |
| GSE74703 | PGRMC2 | 10424 | 0 | 10 | 26 | |
| GSE74704 | PGRMC2 | 10424 | 0 | 6 | 14 | |
| TCGA | PGRMC2 | 10424 | 7 | 36 | 53 |
Total number of gains: 18; Total number of losses: 162; Total Number of normals: 308.
Somatic mutations of PGRMC2:
Generating mutation plots.
Highly correlated genes for PGRMC2:
Showing top 20/1642 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGRMC2 | FNIP2 | 0.771119 | 3 | 0 | 3 |
| PGRMC2 | FBXO8 | 0.748975 | 6 | 0 | 6 |
| PGRMC2 | MYOCD | 0.746811 | 5 | 0 | 5 |
| PGRMC2 | CRBN | 0.746175 | 8 | 0 | 7 |
| PGRMC2 | TBX5-AS1 | 0.744572 | 3 | 0 | 3 |
| PGRMC2 | HDHD2 | 0.742074 | 5 | 0 | 5 |
| PGRMC2 | RASSF3 | 0.738689 | 4 | 0 | 4 |
| PGRMC2 | GRHPR | 0.734147 | 5 | 0 | 5 |
| PGRMC2 | EIF1AY | 0.732977 | 3 | 0 | 3 |
| PGRMC2 | NEGR1 | 0.731909 | 6 | 0 | 6 |
| PGRMC2 | ANGPTL1 | 0.728097 | 6 | 0 | 6 |
| PGRMC2 | ZBTB47 | 0.725251 | 3 | 0 | 3 |
| PGRMC2 | RAP1A | 0.720141 | 11 | 0 | 10 |
| PGRMC2 | SNX18 | 0.714458 | 3 | 0 | 3 |
| PGRMC2 | SNTB1 | 0.714445 | 7 | 0 | 7 |
| PGRMC2 | SNORA68 | 0.712209 | 3 | 0 | 3 |
| PGRMC2 | CLEC3B | 0.710072 | 3 | 0 | 3 |
| PGRMC2 | MEF2D | 0.709819 | 5 | 0 | 4 |
| PGRMC2 | CALCOCO2 | 0.707746 | 10 | 0 | 10 |
| PGRMC2 | EIF4E3 | 0.707038 | 7 | 0 | 7 |
For details and further investigation, click here
