| Full name: phosphatase and actin regulator 3 | Alias Symbol: PPP1R123 | ||
| Type: protein-coding gene | Cytoband: 20q13.32-q13.33 | ||
| Entrez ID: 116154 | HGNC ID: HGNC:15833 | Ensembl Gene: ENSG00000087495 | OMIM ID: 608725 |
| Drug and gene relationship at DGIdb | |||
Expression of PHACTR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHACTR3 | 116154 | 227949_at | 0.6706 | 0.3970 | |
| GSE26886 | PHACTR3 | 116154 | 227949_at | 0.1347 | 0.2165 | |
| GSE45670 | PHACTR3 | 116154 | 227949_at | -0.2531 | 0.1650 | |
| GSE53622 | PHACTR3 | 116154 | 81165 | -0.4175 | 0.0840 | |
| GSE53624 | PHACTR3 | 116154 | 81165 | 0.0020 | 0.9945 | |
| GSE63941 | PHACTR3 | 116154 | 227949_at | 0.3881 | 0.3901 | |
| GSE77861 | PHACTR3 | 116154 | 227949_at | -0.0488 | 0.7159 | |
| GSE97050 | PHACTR3 | 116154 | A_33_P3289371 | -0.0256 | 0.9349 | |
| SRP133303 | PHACTR3 | 116154 | RNAseq | 0.6149 | 0.2356 | |
| SRP159526 | PHACTR3 | 116154 | RNAseq | 2.4956 | 0.0098 | |
| TCGA | PHACTR3 | 116154 | RNAseq | -0.3722 | 0.5760 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PHACTR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHACTR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHACTR3 | 116154 | 13 | 2 | 15 | |
| GSE20123 | PHACTR3 | 116154 | 14 | 2 | 14 | |
| GSE43470 | PHACTR3 | 116154 | 13 | 0 | 30 | |
| GSE46452 | PHACTR3 | 116154 | 29 | 0 | 30 | |
| GSE47630 | PHACTR3 | 116154 | 24 | 1 | 15 | |
| GSE54993 | PHACTR3 | 116154 | 0 | 17 | 53 | |
| GSE54994 | PHACTR3 | 116154 | 29 | 0 | 24 | |
| GSE60625 | PHACTR3 | 116154 | 0 | 0 | 11 | |
| GSE74703 | PHACTR3 | 116154 | 11 | 0 | 25 | |
| GSE74704 | PHACTR3 | 116154 | 11 | 0 | 9 | |
| TCGA | PHACTR3 | 116154 | 43 | 4 | 49 |
Total number of gains: 187; Total number of losses: 26; Total Number of normals: 275.
Somatic mutations of PHACTR3:
Generating mutation plots.
Highly correlated genes for PHACTR3:
Showing all 19 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHACTR3 | ARHGAP22 | 0.701669 | 3 | 0 | 3 |
| PHACTR3 | CCDC142 | 0.69409 | 3 | 0 | 3 |
| PHACTR3 | PRKAR1B | 0.664354 | 3 | 0 | 3 |
| PHACTR3 | SALL4 | 0.653739 | 3 | 0 | 3 |
| PHACTR3 | DUSP9 | 0.633082 | 3 | 0 | 3 |
| PHACTR3 | OGFR | 0.631735 | 3 | 0 | 3 |
| PHACTR3 | HOXA11 | 0.615462 | 4 | 0 | 3 |
| PHACTR3 | DNAH2 | 0.614165 | 3 | 0 | 3 |
| PHACTR3 | LHFPL1 | 0.613113 | 3 | 0 | 3 |
| PHACTR3 | HOXD10 | 0.603662 | 3 | 0 | 3 |
| PHACTR3 | ZNF572 | 0.574036 | 4 | 0 | 3 |
| PHACTR3 | HOXD9 | 0.572612 | 4 | 0 | 3 |
| PHACTR3 | CDC25C | 0.572467 | 3 | 0 | 3 |
| PHACTR3 | PRMT5 | 0.564375 | 4 | 0 | 3 |
| PHACTR3 | GDPD5 | 0.560848 | 4 | 0 | 3 |
| PHACTR3 | EPHB2 | 0.55819 | 4 | 0 | 3 |
| PHACTR3 | NPW | 0.554498 | 4 | 0 | 3 |
| PHACTR3 | RNF216 | 0.552896 | 3 | 0 | 3 |
| PHACTR3 | DHRS2 | 0.518235 | 4 | 0 | 3 |
For details and further investigation, click here
