| Full name: EPH receptor B2 | Alias Symbol: Hek5|Tyro5 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 2048 | HGNC ID: HGNC:3393 | Ensembl Gene: ENSG00000133216 | OMIM ID: 600997 |
| Drug and gene relationship at DGIdb | |||
EPHB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHB2 | 2048 | 209588_at | 0.3969 | 0.3617 | |
| GSE20347 | EPHB2 | 2048 | 209588_at | 0.0168 | 0.8970 | |
| GSE23400 | EPHB2 | 2048 | 209588_at | -0.1436 | 0.0052 | |
| GSE26886 | EPHB2 | 2048 | 210651_s_at | -0.0096 | 0.9568 | |
| GSE29001 | EPHB2 | 2048 | 209588_at | 0.1181 | 0.6190 | |
| GSE38129 | EPHB2 | 2048 | 209588_at | 0.0256 | 0.8123 | |
| GSE45670 | EPHB2 | 2048 | 209588_at | 0.4378 | 0.0004 | |
| GSE53622 | EPHB2 | 2048 | 147693 | 1.7284 | 0.0000 | |
| GSE53624 | EPHB2 | 2048 | 147693 | 1.7304 | 0.0000 | |
| GSE63941 | EPHB2 | 2048 | 209589_s_at | 0.6650 | 0.2626 | |
| GSE77861 | EPHB2 | 2048 | 210651_s_at | -0.1602 | 0.2240 | |
| GSE97050 | EPHB2 | 2048 | A_33_P3370787 | 1.3119 | 0.1403 | |
| SRP007169 | EPHB2 | 2048 | RNAseq | 4.0398 | 0.0000 | |
| SRP008496 | EPHB2 | 2048 | RNAseq | 3.6321 | 0.0000 | |
| SRP064894 | EPHB2 | 2048 | RNAseq | 3.9148 | 0.0000 | |
| SRP133303 | EPHB2 | 2048 | RNAseq | 2.6320 | 0.0000 | |
| SRP159526 | EPHB2 | 2048 | RNAseq | 2.5002 | 0.0000 | |
| SRP219564 | EPHB2 | 2048 | RNAseq | 3.8416 | 0.0000 | |
| TCGA | EPHB2 | 2048 | RNAseq | 0.7325 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by EPHB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHB2 | 2048 | 0 | 5 | 25 | |
| GSE20123 | EPHB2 | 2048 | 0 | 4 | 26 | |
| GSE43470 | EPHB2 | 2048 | 2 | 6 | 35 | |
| GSE46452 | EPHB2 | 2048 | 5 | 1 | 53 | |
| GSE47630 | EPHB2 | 2048 | 8 | 3 | 29 | |
| GSE54993 | EPHB2 | 2048 | 2 | 1 | 67 | |
| GSE54994 | EPHB2 | 2048 | 11 | 4 | 38 | |
| GSE60625 | EPHB2 | 2048 | 0 | 0 | 11 | |
| GSE74703 | EPHB2 | 2048 | 1 | 4 | 31 | |
| GSE74704 | EPHB2 | 2048 | 0 | 0 | 20 | |
| TCGA | EPHB2 | 2048 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of EPHB2:
Generating mutation plots.
Highly correlated genes for EPHB2:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHB2 | MYO1G | 0.765816 | 3 | 0 | 3 |
| EPHB2 | SH2D2A | 0.747233 | 6 | 0 | 6 |
| EPHB2 | BOP1 | 0.731657 | 3 | 0 | 3 |
| EPHB2 | COL10A1 | 0.7042 | 4 | 0 | 3 |
| EPHB2 | TTYH3 | 0.699956 | 5 | 0 | 4 |
| EPHB2 | HOXD10 | 0.692676 | 5 | 0 | 4 |
| EPHB2 | C19orf48 | 0.691355 | 3 | 0 | 3 |
| EPHB2 | KRT16 | 0.690769 | 3 | 0 | 3 |
| EPHB2 | P4HA2 | 0.674796 | 3 | 0 | 3 |
| EPHB2 | SNX10 | 0.673791 | 5 | 0 | 4 |
| EPHB2 | CSMD2 | 0.671289 | 3 | 0 | 3 |
| EPHB2 | C4orf48 | 0.66261 | 5 | 0 | 5 |
| EPHB2 | RNASEH2A | 0.661781 | 4 | 0 | 3 |
| EPHB2 | LRWD1 | 0.660769 | 3 | 0 | 3 |
| EPHB2 | FADS3 | 0.652176 | 5 | 0 | 4 |
| EPHB2 | MUTYH | 0.652151 | 3 | 0 | 3 |
| EPHB2 | CCL24 | 0.651235 | 4 | 0 | 3 |
| EPHB2 | YDJC | 0.650727 | 3 | 0 | 3 |
| EPHB2 | ACTL10 | 0.65006 | 3 | 0 | 3 |
| EPHB2 | TYMP | 0.649894 | 6 | 0 | 5 |
For details and further investigation, click here
