| Full name: phosphoglycerate dehydrogenase | Alias Symbol: SERA|PGDH|PDG | ||
| Type: protein-coding gene | Cytoband: 1p12 | ||
| Entrez ID: 26227 | HGNC ID: HGNC:8923 | Ensembl Gene: ENSG00000092621 | OMIM ID: 606879 |
| Drug and gene relationship at DGIdb | |||
Expression of PHGDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHGDH | 26227 | 201397_at | -0.4093 | 0.5703 | |
| GSE20347 | PHGDH | 26227 | 201397_at | -0.3198 | 0.1980 | |
| GSE23400 | PHGDH | 26227 | 201397_at | -0.2816 | 0.0085 | |
| GSE26886 | PHGDH | 26227 | 201397_at | -0.6802 | 0.0241 | |
| GSE29001 | PHGDH | 26227 | 201397_at | -0.2750 | 0.5116 | |
| GSE38129 | PHGDH | 26227 | 201397_at | -0.1237 | 0.5686 | |
| GSE45670 | PHGDH | 26227 | 201397_at | -0.6147 | 0.0311 | |
| GSE53622 | PHGDH | 26227 | 48052 | -0.6322 | 0.0001 | |
| GSE53624 | PHGDH | 26227 | 48052 | -0.4508 | 0.0000 | |
| GSE63941 | PHGDH | 26227 | 201397_at | 1.7641 | 0.0334 | |
| GSE77861 | PHGDH | 26227 | 201397_at | -0.3209 | 0.1816 | |
| GSE97050 | PHGDH | 26227 | A_23_P85783 | -0.3387 | 0.2566 | |
| SRP007169 | PHGDH | 26227 | RNAseq | -0.4724 | 0.1785 | |
| SRP008496 | PHGDH | 26227 | RNAseq | -0.5707 | 0.1342 | |
| SRP064894 | PHGDH | 26227 | RNAseq | -0.5692 | 0.1159 | |
| SRP133303 | PHGDH | 26227 | RNAseq | -0.6002 | 0.1203 | |
| SRP193095 | PHGDH | 26227 | RNAseq | -0.5635 | 0.0225 | |
| SRP219564 | PHGDH | 26227 | RNAseq | -0.2880 | 0.6355 | |
| TCGA | PHGDH | 26227 | RNAseq | -0.0186 | 0.9005 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PHGDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHGDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHGDH | 26227 | 3 | 5 | 22 | |
| GSE20123 | PHGDH | 26227 | 4 | 5 | 21 | |
| GSE43470 | PHGDH | 26227 | 1 | 3 | 39 | |
| GSE46452 | PHGDH | 26227 | 2 | 1 | 56 | |
| GSE47630 | PHGDH | 26227 | 11 | 3 | 26 | |
| GSE54993 | PHGDH | 26227 | 0 | 2 | 68 | |
| GSE54994 | PHGDH | 26227 | 12 | 1 | 40 | |
| GSE60625 | PHGDH | 26227 | 0 | 0 | 11 | |
| GSE74703 | PHGDH | 26227 | 1 | 3 | 32 | |
| GSE74704 | PHGDH | 26227 | 2 | 3 | 15 | |
| TCGA | PHGDH | 26227 | 18 | 23 | 55 |
Total number of gains: 54; Total number of losses: 49; Total Number of normals: 385.
Somatic mutations of PHGDH:
Generating mutation plots.
Highly correlated genes for PHGDH:
Showing top 20/69 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHGDH | LEMD1-AS1 | 0.686306 | 3 | 0 | 3 |
| PHGDH | PRB4 | 0.678121 | 3 | 0 | 3 |
| PHGDH | PCBP1-AS1 | 0.613338 | 3 | 0 | 3 |
| PHGDH | NDUFA1 | 0.574604 | 4 | 0 | 3 |
| PHGDH | LINC00992 | 0.569952 | 3 | 0 | 3 |
| PHGDH | SLC25A6 | 0.569676 | 3 | 0 | 3 |
| PHGDH | SLC25A21 | 0.565579 | 4 | 0 | 3 |
| PHGDH | RPL14 | 0.563704 | 5 | 0 | 4 |
| PHGDH | TTN | 0.563396 | 3 | 0 | 3 |
| PHGDH | LINC01360 | 0.559936 | 3 | 0 | 3 |
| PHGDH | COX5A | 0.559445 | 4 | 0 | 3 |
| PHGDH | HTR1B | 0.557492 | 3 | 0 | 3 |
| PHGDH | CREB3L4 | 0.556653 | 3 | 0 | 3 |
| PHGDH | KCNE3 | 0.555711 | 3 | 0 | 3 |
| PHGDH | TCEA3 | 0.555331 | 4 | 0 | 3 |
| PHGDH | TRIM2 | 0.551432 | 7 | 0 | 4 |
| PHGDH | SH3BGRL2 | 0.550239 | 7 | 0 | 3 |
| PHGDH | SPINK5 | 0.548733 | 4 | 0 | 3 |
| PHGDH | ZNF784 | 0.547111 | 3 | 0 | 3 |
| PHGDH | PANK1 | 0.544716 | 6 | 0 | 4 |
For details and further investigation, click here
