C1R

 

Full name: complement C1r Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 715 HGNC ID: HGNC:1246 Ensembl Gene: ENSG00000159403 OMIM ID: 613785
Drug and gene relationship at DGIdb

 

C1R involved pathways:

KEGG pathway Description View
hsa04610Complement and coagulation cascades
hsa05133Pertussis
hsa05150Staphylococcus aureus infection

 

Expression of C1R:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C1R 715 212067_s_at 0.0335 0.9740
GSE20347 C1R 715 212067_s_at 0.8068 0.0009
GSE23400 C1R 715 212067_s_at 0.4562 0.0083
GSE26886 C1R 715 212067_s_at 1.8911 0.0011
GSE29001 C1R 715 212067_s_at 1.1689 0.0045
GSE38129 C1R 715 212067_s_at 0.3980 0.3330
GSE45670 C1R 715 212067_s_at -0.6443 0.0844
GSE53622 C1R 715 61263 0.2358 0.0375
GSE53624 C1R 715 61263 0.6567 0.0000
GSE63941 C1R 715 212067_s_at -3.6271 0.0041
GSE77861 C1R 715 212067_s_at 1.5033 0.0097
GSE97050 C1R 715 A_33_P3393821 0.4800 0.2379
SRP007169 C1R 715 RNAseq 1.8221 0.0001
SRP008496 C1R 715 RNAseq 2.3436 0.0000
SRP064894 C1R 715 RNAseq 0.9276 0.0098
SRP133303 C1R 715 RNAseq 0.4122 0.1910
SRP159526 C1R 715 RNAseq 0.5621 0.1161
SRP193095 C1R 715 RNAseq 1.7724 0.0000
SRP219564 C1R 715 RNAseq 1.0218 0.1907
TCGA C1R 715 RNAseq 0.0635 0.4576

Upregulated datasets: 6; Downregulated datasets: 1.  

 

Survival by C1R expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C1R:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C1R 715 7 3 20
GSE20123 C1R 715 7 3 20
GSE43470 C1R 715 8 3 32
GSE46452 C1R 715 10 1 48
GSE47630 C1R 715 12 2 26
GSE54993 C1R 715 1 10 59
GSE54994 C1R 715 10 2 41
GSE60625 C1R 715 0 1 10
GSE74703 C1R 715 7 2 27
GSE74704 C1R 715 4 2 14
TCGA C1R 715 40 6 50

Total number of gains: 106; Total number of losses: 35; Total Number of normals: 347.  

 

Somatic mutations of C1R:

 

Generating mutation plots.

 

Highly correlated genes for C1R:

 

Showing top 20/1116 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C1RC1S0.89745613013
C1RSERPING10.73211513011
C1RSCYL10.730948303
C1RFUCA20.723772303
C1RPHLDB20.72009303
C1RALKBH60.707791303
C1RBICC10.705762908
C1RIFITM20.70348712012
C1RVCAM10.69922710010
C1RDRAM10.69403513012
C1RFSTL10.69375113010
C1RMMP20.69223810010
C1RSH3RF30.691822505
C1RTMEM176A0.68831512010
C1RRASA30.687681707
C1RIGFBP40.68591611010
C1RIGFBP70.68482213012
C1RCD1630.68463712012
C1RFBN10.684411009
C1RAEBP10.68423512012

For details and further investigation, click here